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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000476535':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
2) '9606.ENSP00000265351':
XPO5 - Exportin-5; Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of [...]
[a.k.a. UPI0000E0A1D0, KF458158, ENSP00000313407]
3) '9606.ENSP00000375593':
ZSCAN5A - Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation.
[a.k.a. URS00008B49A5, NM_001322074.2, NP_001308993]
4) '9606.ENSP00000480262':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
5) '9606.ENSP00000355471':
TFB2M - Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- templ [...]
[a.k.a. TFB2M_HUMAN, XP_016857544, 6ERQ]
6) '9606.ENSP00000303511':
PEX6 - Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
[a.k.a. HPA074179, NM_000287, ENST00000244546]
7) '9606.ENSP00000363746':
WDR46 - WD repeat-containing protein 46; Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.
[a.k.a. WD repeat domain 46, XP_016866974.1, ENST00000473611.5]
8) '9606.ENSP00000252445':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000385025':
SMCR8 - Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activ [...]
[a.k.a. SMCR8-C9orf72 complex subunit, BC142680, Q8TEV9]
10) '9606.ENSP00000317891':
TNIP1 - TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B- dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1- dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this f [...]
[a.k.a. ENSP00000430279, KIAA0113, Q15025]
11) '9606.ENSP00000399392':
C3orf52 - TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.
[a.k.a. ENST00000467942.2, NM_024616.2, TTMP_HUMAN]
12) '9606.ENSP00000483117':
ACD - Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodim [...]
[a.k.a. R-HSA-1474165, AC010530, UPI0000246BB2]
13) '9606.ENSP00000396673':
FTSJ3 - pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
[a.k.a. 117246, NM_017647, EAW94273.1]
14) '9606.ENSP00000334148':
WDR25 - WD repeat domain 25.
[a.k.a. BC003641, ENSP00000334654, XM_011537150.2]
15) '9606.ENSP00000379434':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
16) '9606.ENSP00000470652':
SLC35E1 - Solute carrier family 35 member E1; Putative transporter.
[a.k.a. Solute carrier family 35, member E1, 79939, AK075355]
17) '9606.ENSP00000461930':
MRPS21 - Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family.
[a.k.a. R-HSA-5368286, BC004566, NP_114107.1]
18) '9606.ENSP00000200453':
PPP1R15A - Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
[a.k.a. R-HSA-170834, 23645, R-HSA-162582]
19) '9606.ENSP00000469240':
CHMP2A - Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...]
[a.k.a. ENST00000601220.5, R-HSA-162587, NM_014453.4]
20) '9606.ENSP00000334153':
RFTN1 - Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). [...]
[a.k.a. RFTN1-204, ENST00000449415.5, F8WAR1]
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