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Fen1 Fen1 Pif1 Pif1 Lig1 Lig1 Rpa2 Rpa2 Rpa1 Rpa1 Dna2 Dna2 Rad52 Rad52 Exo1 Exo1 Wdhd1 Wdhd1 ENSRNOG00000047206 ENSRNOG00000047206 Gen1 Gen1
"Dna2" - DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 in Rattus norvegicus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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Dna2DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruit [...] (1059 aa)    
Predicted Functional Partners:
Wdhd1
WD repeat and HMG-box DNA-binding protein 1 (1117 aa)
     
 
  0.967
Fen1
Flap endonuclease 1 ; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (380 aa)
   
 
  0.964
Rpa1
Replication protein A 70 kDa DNA-binding subunit (680 aa)
     
 
  0.963
Exo1
Exonuclease 1 (836 aa)
   
 
  0.915
Gen1
Flap endonuclease GEN homolog 1 (908 aa)
   
 
  0.879
Pif1
ATP-dependent DNA helicase PIF1 ; DNA-dependent ATPase and 5’-3’ DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DN [...] (637 aa)
     
 
  0.861
Rad52
DNA repair protein RAD52 homolog (427 aa)
     
 
  0.817
Rpa2
Replication protein A 32 kDa subunit ; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATR [...] (270 aa)
     
 
  0.808
ENSRNOG00000047206
DNA ligase (832 aa)
     
 
  0.797
Lig1
DNA ligase 1 ; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (912 aa)
     
 
  0.788
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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