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Runx2 Runx2 Bglap Bglap Ncor1 Ncor1 Foxo1 Foxo1 Med1 Med1 Vdr Vdr Ncor2 Ncor2 Foxo3 Foxo3 Ncoa1 Ncoa1 Rxra Rxra Ncoa2 Ncoa2
"Vdr" - Vitamin D3 receptor in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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VdrVitamin D3 receptor ; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis (423 aa)    
Predicted Functional Partners:
Rxra
Retinoic acid receptor RXR-alpha ; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid re [...] (467 aa)
       
0.933
Med1
Mediator of RNA polymerase II transcription subunit 1 (1567 aa)
     
  0.889
Foxo1
Forkhead box protein O1 ; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteoca [...] (649 aa)
       
  0.837
Foxo3
Forkhead box protein O3 (672 aa)
       
  0.837
Ncoa2
Nuclear receptor coactivator 2 ; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock [...] (1465 aa)
       
  0.776
Ncoa1
Nuclear receptor coactivator 1 (1417 aa)
       
  0.750
Runx2
Runt-related transcription factor 2 ; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’- PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activa [...] (529 aa)
       
 
  0.748
Bglap
Osteocalcin ; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (99 aa)
           
  0.735
Ncor1
Nuclear receptor corepressor 1 (1589 aa)
       
  0.730
Ncor2
Nuclear receptor corepressor 2 (2472 aa)
       
  0.722
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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