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F2r F2r F2rl3 F2rl3 Il6 Il6 ENSRNOG00000048869 ENSRNOG00000048869 Kitlg Kitlg Tpsab1 Tpsab1 Il4 Il4 Csf2 Csf2 Sspo Sspo F2rl1 F2rl1 Cpa3 Cpa3
"Tpsab1" - Tryptase precursor in Rattus norvegicus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
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Tpsab1Tryptase precursor ; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity) (310 aa)    
Predicted Functional Partners:
Sspo
SCO-spondin ; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity) (5141 aa)
     
  0.918
F2r
Proteinase-activated receptor 1 precursor ; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis (403 aa)
       
  0.774
F2rl1
Proteinase-activated receptor 2 ; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistica [...] (397 aa)
       
 
  0.749
Kitlg
Kit ligand Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ER [...] (272 aa)
       
 
  0.686
Csf2
Granulocyte-macrophage colony-stimulating factor ; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes (144 aa)
           
  0.685
Cpa3
Mast cell carboxypeptidase A (417 aa)
   
  0.651
ENSRNOG00000048869
Ribonuclease 3; Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity) (155 aa)
           
  0.611
Il6
Interleukin-6 ; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and pla [...] (211 aa)
           
  0.611
Il4
Interleukin-4 ; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (147 aa)
           
  0.611
F2rl3
Proteinase-activated receptor 4 ; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation (395 aa)
       
  0.598
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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