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Cyp7a1 Cyp7a1 Abcg8 Abcg8 Atp1a4 Atp1a4 Abcg5 Abcg5 Atp1a1 Atp1a1 Abcb9 Abcb9 Atp1a2 Atp1a2 Atp1a3 Atp1a3 Atp1b1 Atp1b1 Atp1b3 Atp1b3 Fxyd2 Fxyd2
"Abcg8" - ATP-binding cassette sub-family G member 8 in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Abcg8ATP-binding cassette sub-family G member 8 ; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (694 aa)    
Predicted Functional Partners:
Abcg5
ATP-binding cassette sub-family G member 5 ; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (652 aa)
     
0.985
Abcb9
ATP-binding cassette sub-family B member 9 ; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (By similarity) (766 aa)
     
0.920
Atp1a4
Sodium/potassium-transporting ATPase subunit alpha-4 ; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility (1028 aa)
     
  0.913
Atp1a2
Sodium/potassium-transporting ATPase subunit alpha-2 ; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (1020 aa)
     
  0.913
Atp1a1
Sodium/potassium-transporting ATPase subunit alpha-1 ; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (1023 aa)
     
  0.913
Atp1a3
Sodium/potassium-transporting ATPase subunit alpha-3 ; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (1013 aa)
     
  0.913
Atp1b3
Sodium/potassium-transporting ATPase subunit beta-3 ; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (279 aa)
     
 
    0.901
Atp1b1
Sodium/potassium-transporting ATPase subunit beta-1 ; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (304 aa)
     
 
    0.901
Fxyd2
Sodium/potassium-transporting ATPase subunit gamma ; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase (66 aa)
         
    0.900
Cyp7a1
Cholesterol 7-alpha-monooxygenase ; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis (503 aa)
     
   
  0.747
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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