Full Link:
STRINGSTRING
fhs fhs glyA1 glyA1 VC_2685 VC_2685 glyA2 glyA2 metK metK metH metH metE metE VC_2684 VC_2684 VC_A0530 VC_A0530 VC_2364 VC_2364 VC_1671 VC_1671
"metH" - B12-dependent methionine synthase in Vibrio cholerae O1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1226 aa)    
Predicted Functional Partners:
VC_2685
5,10-methylenetetrahydrofolate reductase (295 aa)
 
 
  0.999
glyA2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (435 aa)
     
 
  0.996
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (385 aa)
   
 
  0.995
VC_1671
Cystathionine beta-lyase (396 aa)
   
 
  0.993
glyA1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (416 aa)
     
 
  0.990
fhs
Formate--tetrahydrofolate ligase (582 aa)
   
 
  0.987
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (761 aa)
   
 
  0.987
VC_2364
Bifunctional aspartokinase I/homoserine dehydrogenase I (819 aa)
   
 
  0.979
VC_2684
Bifunctional aspartate kinase II/homoserine dehydrogenase II (803 aa)
   
 
  0.978
VC_A0530
Pyruvate-flavoredoxin oxidoreductase (1079 aa)
       
  0.959
Your Current Organism:
Vibrio cholerae O1
NCBI taxonomy Id: 243277
Other names: V. cholerae O1, V. cholerae O1 biovar El Tor, V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1, Vibrio cholerae O1 biovar El Tor, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae biovar El Tor, Vibrio cholerae biovar eltor, Vibrio cholerae serogroup O1, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961, Vibrio eltor
Server load: low (2%)