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oxaA1 oxaA1 rpmH rpmH mnmE mnmE mnmA mnmA rnpA rnpA gidA gidA prfA prfA dnaA dnaA obg obg lepA lepA topB2 topB2
"gidA" - tRNA uridine 5-carboxymethylaminomethyl modification protein GidA in Clostridium difficile
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second shell of interactors
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co-expression
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gidAtRNA uridine 5-carboxymethylaminomethyl modification protein GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (631 aa)    
Predicted Functional Partners:
mnmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (459 aa)
 
 
  0.996
rnpA
Ribonuclease P; RNaseP catalyzes the removal of the 5’-leader sequence from pre-tRNA to produce the mature 5’-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5’-leader sequence and broadening the substrate specificity of the ribozyme (114 aa)
   
   
  0.864
dnaA
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box)- 5’-TTATC[CA]A[CA]A-3’. DnaA binds to ATP and to acidic phospholipids (439 aa)
 
 
  0.846
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (601 aa)
 
   
  0.838
obg
Spo0B-associated GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (425 aa)
   
 
  0.803
oxaA1
Sporulation membrane protein (235 aa)
   
   
  0.790
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (361 aa)
 
 
  0.777
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (354 aa)
 
   
  0.737
rpmH
50S ribosomal protein L34 (45 aa)
   
   
  0.733
topB2
DNA topoisomerase III (706 aa)
   
   
  0.708
Your Current Organism:
Clostridium difficile
NCBI taxonomy Id: 272563
Other names: Bacillus difficilis, C. difficile, C. difficile 630, Clostridium difficile, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, [Clostridium] difficile
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