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PRKAR2B PRKAR2B prkar1aa prkar1aa WDR19 WDR19 prkacb prkacb prkar2ab prkar2ab gpr161 gpr161 ENSDARG00000058903 ENSDARG00000058903 prkar2aa prkar2aa ift140 ift140 ttc21b ttc21b wdr35 wdr35
"gpr161" - G protein-coupled receptor 161 in Danio rerio
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
gpr161G protein-coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA- dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle (526 aa)    
Predicted Functional Partners:
prkar1aa
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (379 aa)
       
  0.924
prkar2aa
Protein kinase, cAMP-dependent, regulatory, type II, alpha A (397 aa)
       
  0.923
PRKAR2B
Protein kinase, cAMP-dependent, regulatory, type II, beta (320 aa)
       
  0.923
prkacb
Protein kinase, cAMP-dependent, catalytic, beta (351 aa)
     
  0.922
prkar2ab
Protein kinase, cAMP-dependent, regulatory, type II, alpha, B (431 aa)
       
  0.922
WDR19
WD repeat domain 19 (1345 aa)
     
 
  0.920
ift140
Intraflagellar transport 140 homolog (Chlamydomonas) (1455 aa)
     
 
  0.914
ttc21b
Tetratricopeptide repeat domain 21B (1321 aa)
     
 
  0.901
wdr35
WD repeat domain 35 (1203 aa)
     
 
    0.900
ENSDARG00000058903
G protein-coupled receptor 161 (524 aa)
         
 
0.900
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio, Brachydanio rerio, Brachydanio rerio frankei, Celestichthys, Cyprinidae, Cypriniformes, Cypriniphysi, Cyprinoidea, Cyprinoidei, Cyprinus rerio, D. rerio, Danio, Danio frankei, Danio rerio, Danio rerio frankei, Ostariophysi, Otocephala, Otophysi, leopard danio, zebra danio, zebra fish, zebrafish
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