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PAX9 PAX9 FGF17 FGF17 MSX1 MSX1 TWIST1 TWIST1 MSX2 MSX2 FGF8 FGF8 BMP4 BMP4 RUNX2 RUNX2 BMP2 BMP2 WNT3 WNT3 SP7 SP7
"MSX2" - Homeobox protein MSX-2 in Pan troglodytes
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MSX2Homeobox protein MSX-2 ; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity) (267 aa)    
Predicted Functional Partners:
MSX1
Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity) (303 aa)
       
0.822
BMP4
Bone morphogenetic protein 4 (408 aa)
     
   
  0.714
RUNX2
Runt-related transcription factor 2 (591 aa)
       
 
  0.709
TWIST1
Twist-related protein 1 ; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN [...] (117 aa)
           
  0.666
BMP2
Bone morphogenetic protein 2 (398 aa)
     
   
  0.645
FGF8
Fibroblast growth factor 8 (androgen-induced) (206 aa)
     
   
  0.621
SP7
Sp7 transcription factor (413 aa)
       
 
  0.592
FGF17
Fibroblast growth factor 17 (216 aa)
     
   
  0.578
PAX9
Paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (338 aa)
     
 
  0.539
WNT3
Wingless-type MMTV integration site family, member 3; Ligand for members of the frizzled family of seven transmembrane receptors (355 aa)
     
   
  0.526
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, Pan, Pan sp. WO2005014654, Pan sp. WO2007026120, Pan troglodytes, chimpanzee, chimpanzees
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