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FNDC5 FNDC5 ANGPTL3 ANGPTL3 GPIHBP1 GPIHBP1 CUTA CUTA LPL LPL C19orf80 C19orf80 INS INS ANGPTL4 ANGPTL4 RASSF5 RASSF5
"C19orf80" - Chromosome 19 open reading frame 80 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C19orf80Chromosome 19 open reading frame 80; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed-22569073, PubMed-22809513, PubMed-23150577). May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity) (198 aa)    
Predicted Functional Partners:
ANGPTL3
Angiopoietin-like 3; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed-11788823, PubMed-12909640, PubMed-23661675, PubMed-25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 a [...] (460 aa)
     
  0.986
GPIHBP1
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity) (184 aa)
         
  0.927
LPL
Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) (475 aa)
         
  0.921
ANGPTL4
Angiopoietin-like 4; Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and imm [...] (406 aa)
           
  0.649
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (110 aa)
           
  0.639
RASSF5
Ras association (RalGDS/AF-6) domain family member 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulatio [...] (418 aa)
           
  0.611
CUTA
cutA divalent cation tolerance homolog (E. coli); May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE) (198 aa)
           
  0.434
FNDC5
Fibronectin type III domain containing 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue (137 aa)
           
  0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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