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CCL7 CCL7 COA6 COA6 RNF2 RNF2 SH3BGRL SH3BGRL DOT1L DOT1L LXN LXN DAB2IP DAB2IP CPA5 CPA5 CPA2 CPA2 CPA4 CPA4 CPA1 CPA1
"LXN" - Latexin in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
LXNLatexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (222 aa)    
Predicted Functional Partners:
CPA4
Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway (421 aa)
     
 
  0.908
CPA2
Carboxypeptidase A2 (pancreatic) (419 aa)
     
   
  0.763
DAB2IP
DAB2 interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipop [...] (1132 aa)
           
  0.660
CPA1
Carboxypeptidase A1 (pancreatic); Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (419 aa)
     
   
  0.537
COA6
Cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae); Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respi [...] (125 aa)
           
  0.508
SH3BGRL
SH3 domain binding glutamic acid-rich protein like (114 aa)
       
      0.503
CPA5
Carboxypeptidase A5 (436 aa)
     
   
  0.492
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA (1537 aa)
           
  0.487
RNF2
Ring finger protein 2; E3 ubiquitin-protein ligase that mediates monoubiquitination of ’Lys-119’ of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox [...] (336 aa)
           
  0.487
CCL7
Chemokine (C-C motif) ligand 7; Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3 (99 aa)
           
  0.442
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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