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ADI1 ADI1 LOC616683 LOC616683 MAT2A MAT2A MAT1A MAT1A MTR MTR TAT TAT HPD HPD TH TH PAH PAH DDC DDC TYR TYR
"TAT" - Tyrosine aminotransferase in Bos taurus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TATTyrosine aminotransferase ; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity) (447 aa)    
Predicted Functional Partners:
HPD
4-hydroxyphenylpyruvate dioxygenase ; Key enzyme in the degradation of tyrosine (393 aa)
     
 
  0.983
MAT2A
S-adenosylmethionine synthase isoform type-2 ; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (395 aa)
   
 
  0.959
MAT1A
S-adenosylmethionine synthase isoform type-1 ; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (396 aa)
   
 
  0.958
ADI1
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14 (179 aa)
   
 
  0.955
PAH
Phenylalanine-4-hydroxylase (451 aa)
     
 
  0.917
TH
Tyrosine 3-monooxygenase ; Plays an important role in the physiology of adrenergic neurons (491 aa)
     
 
  0.912
DDC
aromatic-L-amino-acid decarboxylase ; Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine (380 aa)
   
 
  0.911
MTR
Methionine synthase ; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1265 aa)
     
 
  0.906
TYR
Tyrosinase precursor ; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone (By similarity) (530 aa)
         
  0.903
LOC616683
Uncharacterized protein (360 aa)
     
 
    0.903
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae, Bovidae sp. Adi Nefas, Bovinae, Pecora, Ruminantia, bovine, cattle, cow, domestic cattle, domestic cow, oxen, cattle
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