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PLD2 PLD2 GBF1 GBF1 AP1G1 AP1G1 AP1S3 AP1S3 ARF1 ARF1 AP1B1 AP1B1 CYTH1 CYTH1 AP4B1 AP4B1 CYTH4 CYTH4 CYTH2 CYTH2 CYTH3 CYTH3
"ARF1" - ADP-ribosylation factor 1 in Bos taurus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ARF1ADP-ribosylation factor 1 ; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] (181 aa)    
Predicted Functional Partners:
CYTH2
Cytohesin-2 ; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity) (410 aa)
     
  0.998
GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (1861 aa)
     
  0.987
CYTH3
Uncharacterized protein (402 aa)
     
  0.983
CYTH1
Uncharacterized protein (401 aa)
     
  0.983
AP1G1
AP-1 complex subunit gamma-1 (825 aa)
     
  0.981
AP1S3
AP-1 complex subunit sigma-3 (154 aa)
     
  0.979
AP1B1
AP-1 complex subunit beta-1 (946 aa)
     
  0.977
PLD2
Phospholipase D2 ; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (904 aa)
     
  0.970
CYTH4
Uncharacterized protein (399 aa)
     
  0.967
AP4B1
AP-4 complex subunit beta-1 (739 aa)
       
  0.964
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae, Bovidae sp. Adi Nefas, Bovinae, Pecora, Ruminantia, bovine, cattle, cow, domestic cattle, domestic cow, oxen, cattle
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