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CXC-R2 CXC-R2 CCR5 CCR5 CXCR4 CXCR4 ADRBK1 ADRBK1 ARRB1 ARRB1 IL8RB IL8RB ARRB2 ARRB2 GNG2 GNG2 GNB1 GNB1 F2R F2R ADRB2 ADRB2
"ADRBK1" - Beta-adrenergic receptor kinase 1 in Bos taurus
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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textmining
co-expression
protein homology
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[Homology]
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ADRBK1Beta-adrenergic receptor kinase 1 ; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity) (652 aa)    
Predicted Functional Partners:
ARRB1
Beta-arrestin-1 ; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (418 aa)
     
  0.980
ARRB2
Beta-arrestin-2 ; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (420 aa)
     
  0.976
ADRB2
Beta-2 adrenergic receptor ; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity) (418 aa)
       
  0.954
IL8RB
C-X-C chemokine receptor type 2 ; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity) (360 aa)
         
  0.946
GNG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 ; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (71 aa)
       
  0.944
CXC-R2
C-X-C chemokine receptor type 2 (363 aa)
         
  0.943
CXCR4
C-X-C chemokine receptor type 4 ; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar developm [...] (353 aa)
     
  0.941
F2R
Proteinase-activated receptor 1 precursor ; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis (427 aa)
     
 
  0.936
CCR5
C-C chemokine receptor type 5 ; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity) (352 aa)
       
  0.926
GNB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 ; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
     
  0.926
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae, Bovidae sp. Adi Nefas, Bovinae, Pecora, Ruminantia, bovine, cattle, cow, domestic cattle, domestic cow, oxen, cattle
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