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SCD - Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...]
[a.k.a. stearoyl-CoA desaturase, CAA73998.1, 126.96.36.199,
SCO3128 - SCE66.07, possible fatty acid desaturase (membrane), len: 336 aa; similar to many (mainly eukaryotic) e.g. SW:
(ACOD_HUMAN) acyl-CoA desaturase (EC 188.8.131.52) from Homo sapiens (Human) (359 aa) fasta scores; opt: 409, z-score: 480.0, E(): 2.9e-19, 29.7% identity in 330 aa overlap. Contains Pfam match to entry PF01069 Desaturase, Fatty acid desaturase and possible membrane-spanning hydrophobic regions.
[a.k.a. CAB95921.1, gene:17760745, Q9K3T6]
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