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PPM1A - Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family
[a.k.a. PPPM1A, Protein phosphatase 2C isoform alpha, ENSP00000378514,
TA15545 - PF00481 Protein phosphatase 2C, signal sequence
[a.k.a. XP_951850.1, Protein phosphatase 2c, Q4UFJ8,
© STRING Consortium 2019
SIB - Swiss Institute of Bioinformatics
CPR - NNF Center for Protein Research
EMBL - European Molecular Biology Laboratory
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