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Frs2 Frs2 Ntf3 Ntf3 Shc1 Shc1 Ntrk2 Ntrk2 Ntf4 Ntf4 Ngf Ngf Bdnf Bdnf Shc2 Shc2 Ngfr Ngfr Shc3 Shc3 Plcg1 Plcg1
"Ntrk2" - BDNF/NT-3 growth factors receptor in Rattus norvegicus
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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Ntrk2BDNF/NT-3 growth factors receptor ; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruit [...] (821 aa)    
Predicted Functional Partners:
Bdnf
Brain-derived neurotrophic factor ; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS (By similarity) (249 aa)
     
  0.998
Ntf4
Neurotrophin-4 ; Could serve as a target-derived trophic factor for sensory and sympathetic neurons (209 aa)
       
  0.997
Ntf3
Neurotrophin-3 ; Seems to promote the survival of visceral and proprioceptive sensory neurons (258 aa)
       
  0.994
Ngf
Beta-nerve growth factor ; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (241 aa)
       
  0.971
Shc2
SHC-transforming protein 2 ; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity) (573 aa)
     
  0.967
Shc3
SHC-transforming protein 3 ; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity) (594 aa)
     
  0.967
Frs2
Fibroblast growth factor receptor substrate 2 (508 aa)
       
  0.961
Plcg1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity) (1290 aa)
       
  0.960
Ngfr
Tumor necrosis factor receptor superfamily member 16 precursor ; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of [...] (425 aa)
     
  0.952
Shc1
SHC-transforming protein 1 isoform a ; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity) (579 aa)
       
  0.936
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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