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3748 matches
showing page 1 of 188
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protein
1)
Saccharomyces cerevisiae
PRP16 - DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
[a.k.a. YKR086W, RNA16, 5LJ5]
2)
Homo sapiens
ALKBH5 -
RNA
demethylase ALKBH5; Dioxygenase that demethylates
RNA
by oxidative demethylation: specifically demethylates N(
6
)-methyladenosine (m6A)
RNA
, the most prevalent internal modification of messenger
RNA
(mRNA) in higher eukaryotes. Can also demethylate N(
6
)-methyladenosine in single- stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of targe [...]
[a.k.a. ENSP00000382091, 4NRM, OFOXD1]
3)
Homo sapiens
FTO - Alpha-ketoglutarate-dependent dioxygenase FTO;
RNA
demethylase that mediates oxidative demethylation of different
RNA
species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(
6
)- methyladenosine (m6A)
RNA
, the most prevalent internal modification of messenger
RNA
(mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear
RNA
(snRNA). Mediates demethylation of N(
6
),2'-O- dimethyladenosine cap (m6A(m)), by demethylating [...]
[a.k.a. XP_011521618, ENSP00000353244, 3LFM]
4)
Homo sapiens
RBM6 -
RNA
-binding protein
6
; Specifically binds poly(G)
RNA
homopolymers in vitro.
[a.k.a. ENSP00000310473, ENSP00000396466, RBM6-212]
5)
Homo sapiens
MPHOSPH6 - M-phase phosphoprotein
6
;
RNA
-binding protein that associates with the
RNA
exosome complex. Involved in the 3'-processing of the 7S pre-
RNA
to the mature 5.8S rRNA and play a role in recruiting the
RNA
exosome complex to pre- rRNA; this function may include C1D.
[a.k.a. CCDS10937, AAH11020.1, ENSG00000135698]
6)
Homo sapiens
UTP6 - U3 small nucleolar
RNA
-associated protein
6
homolog; Involved in nucleolar processing of pre-18S ribosomal
RNA
. Belongs to the UTP6 family.
[a.k.a. U3 small nucleolar RNA-associated protein 6, UTP6-206, ENSG00000108651]
7)
Homo sapiens
ELP6 - Elongator complex protein
6
; Component of the
RNA
polymerase II elongator complex, a multiprotein complex associated with the
RNA
polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity). Belongs to the ELP6 family.
[a.k.a. ENST00000439305, ENSP00000410790, ENST00000446787]
8)
Homo sapiens
CELF6 - CUGBP Elav-like family member
6
;
RNA
-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA; Belongs to the CELF/BRUNOL family.
[a.k.a. ENSP00000439956, ENSP00000369247, UPI000014110E]
9)
Homo sapiens
GTF3C6 - General transcription factor 3C polypeptide
6
; Involved in
RNA
polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated
RNA
promoters.
[a.k.a. GTF3C6-202, NM_138408.4, NM_138408.3]
10)
Homo sapiens
PTBP3 - Polypyrimidine tract-binding protein 3;
RNA
-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon
6
skipping. Binds
RNA
, preferentially to both poly(G) and poly(U).
[a.k.a. NM_001244897.2, AL359073, PTBP3-202]
11)
Homo sapiens
MED6 - Mediator of
RNA
polymerase II transcription subunit
6
; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal
RNA
polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with
RNA
polymerase II and the general transcription factors.
[a.k.a. NM_001284210.1, ENST00000553611, NM_005466.3]
12)
Homo sapiens
PHF6 - PHD finger protein
6
; Transcriptional regulator that associates with ribosomal
RNA
promoters and suppresses ribosomal
RNA
(rRNA) transcription.
[a.k.a. NM_032335.3, BFLS, BORJ]
13)
Homo sapiens
SURF6 - Surfeit locus protein
6
; Binds to both DNA and
RNA
in vitro, with a stronger binding capacity for
RNA
. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).
[a.k.a. Q9BTZ5, AF186772, SURF6_HUMAN]
14)
Homo sapiens
DCP2 - m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Plays a role in replication- dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an
RNA
moiety. The presence of a N(
6
)-methyladenosine methylation at the second tran [...]
[a.k.a. ENST00000513585, 5QOU, 5QOT]
15)
Homo sapiens
TERT - Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the
RNA
component of the enzyme. Catalyzes the
RNA
-dependent extension of 3'-chromosomal termini with the
6
-nuc [...]
[a.k.a. ENST00000484238.6, uc003jcb.2, R-HSA-162582]
16)
Homo sapiens
METTL16 -
RNA
N6-adenosine-methyltransferase METTL16;
RNA
N6-methyltransferase that methylates adenosine residues at the N(
6
) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific
RNA
structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...]
[a.k.a. 6GFK, MET16_HUMAN, RNA N6-adenosine-methyltransferase METTL16]
17)
Homo sapiens
CNOT6L - CCR4-NOT transcription complex subunit
6
-like; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A)
RNA
substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...]
[a.k.a. XM_017007957.2, ENST00000504123, ENST00000515506]
18)
Homo sapiens
PCIF1 - mRNA (2'-O-methyladenosine-N(
6
)-)-methyltransferase; Cap-specific adenosine methyltransferase that catalyzes formation of N(
6
),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of
RNA
polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co- transcriptionally.
[a.k.a. Cap-specific adenosine methyltransferase, AAH13365.1, XP_011527282]
19)
Homo sapiens
METTL14 - N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(
6
) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the
RNA
-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts [...]
[a.k.a. HGNC:29330, 5L6D, UPI0005C122FC]
20)
Homo sapiens
ITPA - Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-
6
-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from
RNA
and DNA precursor pools, thus preventing their incorporation into
RNA
and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.
[a.k.a. NM_181493, AF219116, AAK21848.1]
3748 matches
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