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There are several matches for 'cytosine deaminase'.
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4702 matches
showing page 1 of 236
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organism
protein
1)
Escherichia coli K12
codA - Cytosine/isoguanine
deaminase
; Catalyzes the hydrolytic deamination of
cytosine
to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize
cytosine
for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor. Belongs to the metallo-dependent hydrolases supe [...]
[a.k.a. b0337, AAC73440.1, 1RA5,
Cytosine deaminase
]
2)
Saccharomyces cerevisiae
FCY1 -
Cytosine
deaminase
; zinc metalloenzyme that catalyzes the hydrolytic deamination of
cytosine
to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); Belongs to the cytidine and deoxycytidylate
deaminase
family.
[a.k.a. YPR062W, L000003485, NP_015387,
Cytosine deaminase
,
cytosine deaminase
, ...]
3)
Homo sapiens
AICDA - Single-stranded DNA
cytosine
deaminase
; Single-stranded DNA-specific cytidine
deaminase
. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
[a.k.a. 3.5.4.38, CCDS81662, 5W1C]
4)
Homo sapiens
MCM3AP - Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA
cytosine
deaminase
AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family.
[a.k.a. ENST00000291688.5, ENSP00000437989, GANP_HUMAN]
5)
Homo sapiens
APOBEC3B - DNA dC->dU-editing enzyme APOBEC-3B; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamin [...]
[a.k.a. Q9UE74, DNA dC->dU-editing enzyme APOBEC-3B, ENSP00000385060]
6)
Homo sapiens
APOBEC3C - DNA dC->dU-editing enzyme APOBEC-3C; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamin [...]
[a.k.a. XM_024452218.1, APOBEC1L, APOBEC1-like]
7)
Homo sapiens
APOBEC3D - DNA dC->dU-editing enzyme APOBEC-3D; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels [...]
[a.k.a. BF832090, ENSP00000480718, Q96AK3]
8)
Homo sapiens
APOBEC3F - DNA dC->dU-editing enzyme APOBEC-3F; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels [...]
[a.k.a. ENST00000329012, KA6, UPI000006E433]
9)
Homo sapiens
APOBEC3G - DNA dC->dU-editing enzyme APOBEC-3G; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental [...]
[a.k.a. APOBEC-related protein 9, AF182420, ENST00000461827.5]
10)
Homo sapiens
APOBEC3H - DNA dC->dU-editing enzyme APOBEC-3H; DNA
deaminase
(cytidine
deaminase
) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via
deaminase
- dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of
cytosine
to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resu [...]
[a.k.a. ENST00000401756, OMIM:610976, URS00008BA186]
11)
Homo sapiens
APOBEC3A - DNA dC->dU-editing enzyme APOBEC-3A; DNA
deaminase
(cytidine
deaminase
) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and
cytosine
in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression thro [...]
[a.k.a. APOBEC3A_B, U03891, A3A]
12)
Mus musculus
Aicda - Single-stranded DNA
cytosine
deaminase
; Single-stranded DNA-specific cytidine
deaminase
. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
[a.k.a. 3.5.4.38, UPI0001DD354C, Q9WVE0]
13)
Mus musculus
Mcm3ap - Germinal-center associated nuclear protein; As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA
cytosine
deaminase
AICDA/AID targeting, hence promoting somatic hypermutations ; Belongs to the SAC3 family.
[a.k.a. GANP, UPI00097CE19A, ENSMUSP00000125960]
14)
Acetobacter aceti
AQS84429.1 -
Cytosine
deaminase
; Catalyzes the deamination of
cytosine
to uracil and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology.
[a.k.a. A0U92_06180, AQS84429, aace:A0U92_06180,
cytosine deaminase
,
Cytosine deaminase
, ...]
15)
Acetobacter cibinongensis
tadA -
Cytosine
deaminase
; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate
deaminase
family.
[a.k.a. GAN60826.1, Abci_017_010,
cytosine deaminase
,
Cytosine deaminase
]
16)
Acetobacter indonesiensis
tadA -
Cytosine
deaminase
; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate
deaminase
family.
[a.k.a. GAN63723.1, Abin_042_014, GAN63723,
cytosine deaminase
,
Cytosine deaminase
, ...]
17)
Acetobacter orientalis
tadA -
Cytosine
deaminase
; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate
deaminase
family.
[a.k.a. Abor_033_014, GAN66956.1, TRNA(adenine34) deaminase,
cytosine deaminase
,
Cytosine deaminase
, ...]
18)
Acholeplasma axanthum
codA - Unannotated protein.
[a.k.a. GCA_000428705_01265, 3.5.4.-, TRNA(adenine34) deaminase,
Cytosine deaminase
]
19)
Acholeplasma hippikon
codA - Unannotated protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
[a.k.a. GCA_000702765_01234, TRNA(adenine34) deaminase, unannotated protein,
Cytosine deaminase
]
20)
Achromobacter arsenitoxydans
KYC_00355 - COG0402
Cytosine
deaminase
and related metal-dependent hydrolases.
[a.k.a. EHK68396.1, NZ_AGUF01000001.1,
cytosine deaminase
,
Cytosine deaminase
]
4702 matches
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