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10826 matches

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organism

protein

Escherichia coli K12 MG1655

nth - Dna glycosylase and apyrimidinic (ap) lyase (endonuclease iii); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate [a.k.a. Nth, AAC74705.1, b1633, Endonuclease III]

Homo sapiens

NTHL1 - Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA gly [...] [a.k.a. NTH1, OCTS3, HQ206278]

Homo sapiens

AGO3 - Eukaryotic translation initiation factor 2c; Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase [...] [a.k.a. EIF2C3, argonaute RISC catalytic component 3, eIF2C 3]

Mus musculus

Nthl1 - Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family [a.k.a. Nth1, NP_032769.2, 18207]

Mus musculus

Ago3 - Eukaryotic translation initiation factor 2c; Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase [...] [a.k.a. Eif2c3, eIF2C 3, OTTMUST00000021292]

Drosophila melanogaster

CG9272 - Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family [a.k.a. FBgn0032907, NTH1, DmelCG9272]

Drosophila melanogaster

Dcr-2 - Dicer-2, isoform A; Dicer-2 (Dcr-2) is a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. Dcr-2 helps defend flies against viral infection, particularly RNA viruses. Dcr-2 also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs; Belongs to the helicase family. Dicer subfamily [a.k.a. FBgn0034246, CG6493, Dcr-2-RA]

Caenorhabditis elegans

nth-1 - Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines [a.k.a. R10E4.5d, R10E4.5, Nth-1]

Escherichia coli K12 MG1655

dinG - Atp-dependent dna helicase ding; DNA-dependent ATPase and 5'-3' DNA helicase Can also unwind DNA-RNA hybrid duplexes. Is active on D-loops and R-loops, and on forked structures . May be involved in recombinational DNA repair and the resumption of replication after DNA damage . The redox cluster is involved in DNA-mediated charge-transport signaling between DNA repair proteins from distinct pathways. DinG cooperates at long-range with endonuclease III, a base excision repair enzyme, using DNA charge transport to redistribute to regions of DNA damage [a.k.a. DinG, b0799, AAC73886.1]

10)

Saccharomyces cerevisiae

NTG1 - Endonuclease III homolog 1; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication; Belongs to the Nth/MutY family [a.k.a. FUN33, YAL015C, SCR1]

11)

Saccharomyces cerevisiae

NTG2 - Endonuclease III homolog 2; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication [a.k.a. YOL043C, SCR2, S000005403]

12)

'Candidatus Kapabacteria' thiocyanatum

nth - Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.

13)

Abiotrophia defectiva

nth - Endonuclease iii; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate [a.k.a. Nth, GCWU000182_000061, ESK66374.1, Endonuclease III, endonuclease III, ...]

14)

Acanthamoeba castellanii str. Neff

L8GF10 - Endonuclease III, putative

15)

Acanthamoeba castellanii str. Neff

L8GJ45 - Base excision DNA repair protein, HhHGPD subfamily protein

16)

Acanthamoeba castellanii str. Neff

L8GMW0 - Endonuclease iii, putative

17)

Acanthamoeba castellanii str. Neff

L8HAW0 - Endonuclease III, putative

18)

Acaryochloris marina

nth - Endonuclease iii; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate [a.k.a. Nth, ABW29045.1, AM1_4064, Endonuclease III, endonuclease III, ...]

19)

Accumulibacter phosphatis

nth - Endonuclease iii; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate [a.k.a. Endonuclease III, ACV36231.1, CAP2UW1_2953, endonuclease III]

20)

Accumulibacter sp. BA93

nth - Endonuclease iii; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate [a.k.a. EXI87631.1, AW11_02495, 4.2.99.18, Endonuclease III]

10826 matches

showing page 1 of 542 • first • previous • next • last

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