searching ... STRING: functional protein association networks

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7219 matches

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organism

protein

Homo sapiens

DNAJC3 - DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] [a.k.a. ENST00000602402.5, R-HSA-168254, NX_Q13217]

Homo sapiens

PSIP1 - PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre- mRNA splicing. Cellular cofactor for lentiviral integration. [a.k.a. 1Z9E, R-HSA-162587, PSIP1-208]

Homo sapiens

TNIK - TRAF2 and NCK-interacting protein kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate [...] [a.k.a. C9JVV1, ENST00000436636.6, TRAF2 and NCK interacting kinase]

Mus musculus

Dnajc3 - DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] [a.k.a. EDL00581.1, R-MMU-392499, mmu:100037258]

Mus musculus

Tnik - Traf2 and NCK-interacting protein kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate [...] [a.k.a. uc008oty.1, 1500031A17Rik, NM_026910]

Caenorhabditis elegans

glb-26 - Globin-like protein 26; Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions. [a.k.a. T22C1.2, T22C1.2.1, Globin-like protein 26]

Saccharomyces cerevisiae

WHI2 - Growth regulation protein; Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery. [a.k.a. YOR043W, WHI2_YEAST, S000005569]

Saccharomyces cerevisiae

PSR1 - Phosphatase PSR1; Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication. [a.k.a. YLL010C, 3.1.3.16, 850650]

Saccharomyces cerevisiae

SER1 - 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. [a.k.a. YOR184W, NM_001183603.3, 854356]

10)

Saccharomyces cerevisiae

DST1 - General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress; Belongs to the TFS-II family. [a.k.a. YGL043W, L000001476, 5FMF]

11)

Acetobacter aceti

AQS83610.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. A0U92_01190, A0A1U9KCV9, General stress protein, general stress protein]

12)

Acetobacter aceti

AQS84468.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0337 (CsbD) family. [a.k.a. A0U92_06410, General stress protein, AQS84468, general stress protein]

13)

Acetobacter ascendens

AOW45871.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0337 (CsbD) family. [a.k.a. A4S02_02785, General stress protein, general stress protein]

14)

Acetobacter ascendens

AOW47268.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. A4S02_11350, General stress protein, general stress protein]

15)

Acetobacter okinawensis

HK26_04610 - Unannotated protein. [a.k.a. GCA_000613865_01163, unannotated protein, A0A252BY96, General stress protein]

16)

Acetobacter okinawensis

HK26_10055 - Unannotated protein; Belongs to the UPF0337 (CsbD) family. [a.k.a. GCA_000613865_01887, A0A252BWG8_9PROT, unannotated protein, General stress protein]

17)

Acetobacter orientalis

GAN64958.1 - Aldo/keto reductase. [a.k.a. Abor_003_028, aldo/keto reductase, AcetOri_orf02316, General stress protein]

18)

Acetobacter orientalis

GAN67043.1 - Hypothetical protein; Belongs to the UPF0337 (CsbD) family. [a.k.a. Abor_035_066, A0A0D6NN44, BBC78351, General stress protein]

19)

Acetobacter orleanensis

KXV62151.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0337 (CsbD) family. [a.k.a. AD949_13025, General stress protein, WP_048834627.1, general stress protein]

20)

Acetobacter oryzifermentans

ANA12808.1 - General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. WG31_01230, General stress protein, ANA12808, general stress protein]

7219 matches

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