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1676 matches

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organism

protein

Homo sapiens

MAP3K8 - Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up- [...] [a.k.a. Mitogen-activated protein kinase kinase kinase 8, XP_016871196.1, ESTF]

Homo sapiens

PRKCZ - Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] [a.k.a. R-HSA-170834, ENST00000497183, PRKCZ-203]

Homo sapiens

MAST2 - Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. [a.k.a. NM_001324320.1, MAST2-201, NP_055927]

Homo sapiens

MAP4K2 - Mitogen-activated protein kinase kinase kinase kinase 2; Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6- dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides [...] [a.k.a. NP_004570.2, Rab8-interacting protein, MAP4K2-212]

Homo sapiens

RFTN1 - Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). [...] [a.k.a. RFTN1-204, ENST00000449415.5, F8WAR1]

Mus musculus

Map3k8 - Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a [...] [a.k.a. Mitogen-activated protein kinase kinase kinase 8, R-MMU-1280218, R-MMU-166058]

Mus musculus

Prkcz - Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] [a.k.a. ENSMUST00000103178, NP_001034168.1, Pkcz]

Mus musculus

Mast2 - Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. [a.k.a. XM_006502833, ENSMUST00000106485.7, Mast2-201]

Mus musculus

Rftn1 - Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3- positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. [...] [a.k.a. BAE30971.1, AK152130, Raftlin lipid raft linker 1]

10)

Drosophila melanogaster

Rel - Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...] [a.k.a. FBgn0014018, Rel-PC, Rel-PA]

11)

Drosophila melanogaster

IKKbeta - Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response. [a.k.a. FBgn0024222, IKKbeta-PB, NP_524751.3]

12)

Escherichia coli K12

waaP - Kinase that phosphorylates core heptose of lipopolysaccharide; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. [a.k.a. b3630, AAC76654.1, WP_000229840.1]

13)

Escherichia coli K12

waaY - Lipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. RfaY/WaaY family. [a.k.a. b3625, AAC76649.1, JW3600]

14)

Accumulibacter aalborgensis

SBT03224.1 - Lipopolysaccharide kinase. [a.k.a. ACCAA_10144, Lipopolysaccharide kinase, A0A1A8XDD8_9PROT]

15)

Accumulibacter aalborgensis

SBT10123.1 - Lipopolysaccharide kinase. [a.k.a. ACCAA_890006, Lipopolysaccharide kinase, A0A1A8Y179_9PROT]

16)

Accumulibacter phosphatis

ACV34104.1 - PFAM: lipopolysaccharide kinase; KEGG: pst:PSPTO_4998 lipopolysaccharide biosynthesis protein, putative. [a.k.a. CAP2UW1_0759, lipopolysaccharide kinase, WP_015765352.1, Lipopolysaccharide kinase]

17)

Accumulibacter phosphatis

ACV35141.1 - PFAM: lipopolysaccharide kinase; KEGG: azo:azo3569 lipopolysaccharide core biosynthesis protein. [a.k.a. CAP2UW1_1841, ACV35141, lipopolysaccharide kinase, Lipopolysaccharide kinase]

18)

Accumulibacter phosphatis

ACV37436.1 - Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. [a.k.a. CAP2UW1_4194, lipopolysaccharide kinase, ACV37436, Lipopolysaccharide kinase]

19)

Actinobacteria bacterium 6920

OJV23661.1 - Lipopolysaccharide kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. BGO26_12525, lipopolysaccharide kinase, Lipopolysaccharide kinase]

20)

Actinobaculum suis

OCA93198.1 - Lipopolysaccharide kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. ACU20_02205, lipopolysaccharide kinase, Lipopolysaccharide kinase]

1676 matches

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