searching ... STRING: functional protein association networks

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2190 matches

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organism

protein

Homo sapiens

SLC30A10 - Zinc transporter 10; Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese- induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recy [...] [a.k.a. ZNT10, ZNT8, ENST00000366926]

Homo sapiens

ATP13A1 - Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily [a.k.a. KIAA1825, ATP13A, CGI-152]

Homo sapiens

SLC39A8 - Solute carrier family 39 (zinc transporter), member 8; Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain; Belongs to the ZIP transporter (TC 2.A.5) family [a.k.a. BIGM103, PP3105, ZIP8]

Homo sapiens

SLC11A2 - Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria; Belongs to the NRAMP family [a.k.a. DMT1, NRAMP2, OK/SW-cl.20]

Homo sapiens

SLC11A1 - Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] [a.k.a. LSH, NRAMP, NRAMP1]

Mus musculus

Slc30a10 - Zinc transporter 10; Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese- induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recy [...] [a.k.a. Znt10, CCDS15599.1, ENSMUST00000061093]

Mus musculus

Atp13a1 - Manganese-transporting p-type atpase; Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity) [a.k.a. Atp13a, EC 7.2.2.-, Manganese-transporting P-type ATPase ]

Mus musculus

Slc39a8 - Solute carrier family 39 (metal ion transporter), member 8; Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain [a.k.a. Zip8, NP_001128621.1, XP_006501997.1]

Mus musculus

Slc11a1 - Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generati [...] [a.k.a. Bcg, Lsh, Nramp1]

10)

Drosophila melanogaster

SPoCk - Secretory pathway calcium atpase, isoform G; Calcium-transporting ATPase activity; manganese-transporting ATPase activity; metal ion binding; nucleotide binding. It is involved in the biological process described with: calcium-mediated signaling; sequestering of calcium ion; fluid transport; calcium ion transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family [a.k.a. FBgn0052451, SPoCk-PG, SPoCk-PA]

11)

Caenorhabditis elegans

catp-8 - Probable manganese-transporting ATPase catp-8; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis [a.k.a. C10C6.6, CELE_C10C6.6, Catp-8]

12)

Saccharomyces cerevisiae

PHO84 - High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity [a.k.a. YML123C, YM7056.03C, P25297]

13)

Saccharomyces cerevisiae

SMF1 - Manganese transporter SMF1; Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [a.k.a. YOL122C, ESP1, P38925]

14)

Saccharomyces cerevisiae

SPF1 - Manganese-transporting ATPase 1; P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 [a.k.a. YEL031W, P39986, EC 7.2.2.-]

15)

Saccharomyces cerevisiae

HIP1 - Yeast amino acid transporter; High-affinity histidine permease; also involved in the transport of manganese ions [a.k.a. YGR191W, G7572, UPI000012C728]

16)

Saccharomyces cerevisiae

SMF2 - Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [a.k.a. YHR050W, UPI0000135AA0, P38778]

17)

Escherichia coli K12 MG1655

mntH - Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen [a.k.a. MntH, b2392, AAC75451.1]

18)

Saccharomyces cerevisiae

MNR2 - Manganese resistance protein MNR2; Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [a.k.a. YKL064W, Z28064, P35724]

19)

Saccharomyces cerevisiae

MTM1 - Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor [a.k.a. YGR257C, G9175, sce:YGR257C]

20)

Acetobacter aceti 1023

AZ09_13455 - Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology [a.k.a. KDE19288.1, AZ09_13455, manganese transporter, Manganese transporter]

2190 matches

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