probable two-component sensor - STRING protein network

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organism

protein

Escherichia coli K12 MG1655

yedV - Probable sensor-like histidine kinase YedV; Probable member of a two-component regulatory system YedW/YedV. Activates YedW by phosphorylation [a.k.a. b1968, JW1951, AAC75034.1]

Escherichia coli K12 MG1655

rstB - Sensor protein RstB; Member of the two-component regulatory system RstB/RstA. RstB functions as a membrane-associated protein kinase that phosphorylates RstA (Probable) [a.k.a. JW1601, b1609, uspT]

Escherichia coli K12 MG1655

torS - Sensor protein TorS; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733 [a.k.a. JW5135, b0993, yccI]

Escherichia coli K12 MG1655

cpxP - Periplasmic protein CpxP; Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic prote [...] [a.k.a. JW5558, yiiO, b4484]

Aromatoleum aromaticum

ebA3320 - annotation not available [a.k.a. CAI07996.1, Probable two-component sensor, Q5P3W7, probable two-component sensor]

Blastopirellula marina

EAQ82015.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. DSM3645_17725, Probable two-component sensor, EAQ82015, probable two-component sensor]

Cellvibrio japonicus

CJA_3510 - Probable two-component sensor; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 [a.k.a. ACE83561.1, Probable two-component sensor, cja:CJA_3510, probable two-component sensor]

Chromobacterium violaceum

CV_0896 - Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642 [a.k.a. AAQ58570.1, Probable two-component sensor, AAQ58570, probable two-component sensor]

Chromobacterium violaceum

CV_1521 - Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Blastx/COG0642 [a.k.a. AAQ59196.2, Probable two-component sensor, Q7NXV5_CHRVO, probable two-component sensor]

Chromobacterium violaceum

CV_1951 - Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Blastx/COG0784 [a.k.a. AAQ59623.2, Probable two-component sensor, AAQ59623, probable two-component sensor]

Chromobacterium violaceum

CV_2324 - Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Blastx/COG0642 [a.k.a. AAQ59996.2, Probable two-component sensor, 34332795, probable two-component sensor]

Chromobacterium violaceum

CV_3445 - Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Blastx [a.k.a. AAQ61106.1, Probable two-component sensor, WP_011136992.1, probable two-component sensor]

Fulvimarina pelagi

EAU40093.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. FP2506_02590, Probable two-component sensor, GI:114536964, probable two-component sensor]

Fulvimarina pelagi

EAU41805.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. FP2506_15269, Probable two-component sensor, Q0G3M6, probable two-component sensor]

Gammaproteobacteria bacterium HTCC2143

EAW30676.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. GP2143_01017, Probable two-component sensor, GI:119449437, probable two-component sensor]

Gammaproteobacteria bacterium HTCC2143

EAW31429.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. GP2143_07764, Probable two-component sensor, A0YCB0_9GAMM, probable two-component sensor]

Gammaproteobacteria bacterium HTCC2207

EAS46563.1 - Probable two-component sensor; COG0591 Na+/proline symporter [a.k.a. GB2207_06913, Probable two-component sensor, Q1YQJ8_9GAMM, probable two-component sensor]

Grimontia hollisae

VHA_002094 - annotation not available [a.k.a. EEY72988.1, Probable two-component sensor, D0I8L9_GRIHO, probable two-component sensor]

Halomonas elongata

HELO_3559 - PAS domain protein / sensor histidine kinase / response regulator; Phytochrome 1 - Selaginella martensii (Martenss spike moss),InterPro: Na+/solute symporter, Specificity unclear [a.k.a. CBV43443.1, Probable two-component sensor, InterPro:IPR013656, probable two-component sensor]

Marinobacter algicola

EDM48107.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MDG893_03500, Probable two-component sensor, A6EZA8, probable two-component sensor]

Marinobacter sp. ELB17

EAZ97313.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MELB17_11649, Probable two-component sensor, 126626660, probable two-component sensor]

Marinobacter sp. ELB17

EAZ97824.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MELB17_13087, Probable two-component sensor, A3JJ40, probable two-component sensor]

Marinobacter sp. ELB17

EBA00972.1 - Probable two-component sensor; COG0643 Chemotaxis protein histidine kinase and related kinases [a.k.a. MELB17_18004, Probable two-component sensor, EBA00972, probable two-component sensor]

Marinobacter sp. ELB17

EAZ99514.1 - Probable two-component sensor; COG0591 Na+/proline symporter [a.k.a. MELB17_20396, Probable two-component sensor, GI:126628895, probable two-component sensor]

Mesorhizobium loti MAFF303099

mlr1132 - annotation not available [a.k.a. Probable two-component sensor, Q98L88, BAB48575]

Mesorhizobium loti MAFF303099

mlr1336 - annotation not available [a.k.a. Probable two-component sensor, BAB48733, Q98KT1]

Mesorhizobium loti MAFF303099

mlr2667 - annotation not available [a.k.a. Probable two-component sensor, mlo:mlr2667, Q98HX5]

Neptuniibacter caesariensis

EAR60420.1 - Probable two-component sensor; COG4252 Predicted transmembrane sensor domain [a.k.a. MED92_01109, Probable two-component sensor, Q2BIV4_NEPCE, probable two-component sensor]

Neptuniibacter caesariensis

EAR62776.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MED92_06651, Probable two-component sensor, Q2BRQ0_NEPCE, probable two-component sensor]

Neptuniibacter caesariensis

EAR63029.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MED92_07916, Probable two-component sensor, Q2BQZ7, probable two-component sensor]

Neptuniibacter caesariensis

EAR62233.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. MED92_14388, Probable two-component sensor, Q2BPS4, probable two-component sensor]

Neptuniibacter caesariensis

EAR59865.1 - Probable two-component sensor; COG0591 Na+/proline symporter [a.k.a. MED92_17520, Probable two-component sensor, 89080619, probable two-component sensor]

Nitrosomonas europaea

NE1314 - Probable two-component sensor; InterPro IPR003594:IPR003661:IPR004358:IPR005467 COGs COG0642 [a.k.a. CAD85225.1, Probable two-component sensor, InterPro:IPR003661, probable two-component sensor]

Pedobacter sp. BAL39

EDM35146.1 - Probable two-component sensor; COG0642 Signal transduction histidine kinase [a.k.a. PBAL39_16731, Probable two-component sensor, 149229757, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_0734 - annotation not available [a.k.a. ABP78439.1, Probable two-component sensor, 145569333, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_0850 - Probable two-component sensor; Code: T; COG: COG0642 [a.k.a. ABP78547.1, Probable two-component sensor, WP_011912040.1, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_1003 - Probable two-component sensor; Code: T; COG: COG0642 [a.k.a. ABP78700.1, Probable two-component sensor, A4VI99_PSEU5, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_1981 - annotation not available [a.k.a. ABP79655.1, Probable two-component sensor, A4VL04, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_2710 - Probable two-component sensor; Code: T; COG: COG0642 [a.k.a. ABP80360.1, Probable two-component sensor, psa:PST_2710, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_2779 - annotation not available [a.k.a. ABP80427.1, Probable two-component sensor, GI:145571321, probable two-component sensor]

Pseudomonas stutzeri A1501

PST_3755 - annotation not available [a.k.a. ABP81378.1, Probable two-component sensor, ABP81378, probable two-component sensor]

Rhodopirellula baltica

RB11091 - Probable two-component sensor; PMID: 9045826 PMID: 10564511 best DB hits: BLAST: pir:F83324; probable two-component sensor PA2571 [imported] -; E=5e-36 pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=1e-35 pir:C82425; sensor histide kinase VCA0719 [imported] - Vibrio; E=2e-34 COG: PA2571; COG0642 Sensory transduction histidine kinases; E=5e-37 PFAM: PF00989; PAS domain; E=1.1e-06 PF00512; His Kinase A (phosphoacceptor) doma; E=0.001 PF02518; Histidine kinase-, DNA gyrase B-, p; E=2.9e-30 [a.k.a. NP_869778.1, Probable two-component sensor, GeneID:1793741]

Thalassolituus oleivorans

TOL_2486 - annotation not available [a.k.a. CCU72885.1, Probable two-component sensor, WP_015487603.1, probable two-component sensor]

Thalassolituus oleivorans

TOL_2999 - annotation not available [a.k.a. CCU73395.1, Probable two-component sensor, GI:461493716, probable two-component sensor]

Thermus thermophilus HB27

TT_C0158 - annotation not available [a.k.a. AAS80506.1, Probable two-component sensor, GI:46196088, probable two-component sensor]

Vibrio coralliilyticus

EEX33288.1 - annotation not available [a.k.a. VIC_002742, Probable two-component sensor, 260607014, probable two-component sensor]

Vibrio coralliilyticus

EEX32405.1 - annotation not available [a.k.a. BA953_22450, VIC_003507, Probable two-component sensor, probable two-component sensor]

Vibrio coralliilyticus

EEX31402.1 - annotation not available [a.k.a. VIC_004350, Probable two-component sensor, EEX31402, probable two-component sensor]

Rhizobium etli CFN42

ABC89440.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Similar to blr2986 [Bradyrhizobium japonicum]; Similar to swissprot:Q89QY6; Putative location:bacterial cytoplasm Psort-Score: 0.4147; Protein involved in two-component response regulator activity, two-component sensor molecule activity, ATP binding, kinase activity, DNA binding, two-component signal transduction system (phosphorelay), regulation of transcription, DNA-dependent and signal transduction [a.k.a. RHE_CH00624, PF02518.9, InterPro:IPR001789]

Rhizobium etli CFN42

ABC89384.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Similar to Atu0527 [Agrobacterium tumefaciens str. C58]; Similar to swissprot:Q8UHY1; Putative location:bacterial inner membrane Psort-Score: 0.3951; Protein involved in ATP binding, kinase activity, DNA binding, two-component sensor molecule activity, two-component response regulator activity, transporter activity, regulation of transcription, DNA-dependent, signal transduction, transport and two-component signal transduction system (phosphorelay) [a.k.a. RHE_CH00566, PF02518.9, IPR001734]

Mycobacterium marinum

senX3 - Two-component sensor histidine kinase SenX3; Sensor part of a two-component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3 [a.k.a. MMAR_0815, ACC39275.1, Two-component sensor histidine kinase SenX3]

Clavibacter michiganensis NCPPB382

kdpD - Putative two-component system, sensor kinase (YP_054836.1| two-component sensor, KdpD [Propionibacterium acnes KPA171202]; O34971|KDPD_RATRA Sensor protein kdpD; T34823 probable turgor pressure sensor kdpD - Streptomyces coelicolor). MEMBER OF THE TWO-COMPONENT REGULATORY SYSTEM KDPD/KDPE INVOLVED IN THE REGULATION OF THE KDP OPERON. KDPD MAY FUNCTION AS A MEMBRANE-ASSOCIATED PROTEIN KINASE THAT PHOSPHORYLATES KDPE IN RESPONSE TO ENVIRONMENTAL SIGNALS (BY SIMILARITY). pfam02702, KdpD, Osmosensitive K+ channel His kinase sensor domain. pfam00582, Usp, Universal stress protein family. pf [...] [a.k.a. CMM_2754, CAN02838.1, cmi:CMM_2754]

Rhizobium etli CFN42

ABC91912.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Similar to AGR_C_4237p [Agrobacterium tumefaciens]; Similar to swissprot:Q8UCZ6; Putative location:bacterial inner membrane Psort-Score: 0.1298; Protein involved in DNA binding, two-component sensor molecule activity, signal transducer activity, two-component response regulator activity, ATP binding, kinase activity, signal transduction, two-component signal transduction system (phosphorelay) and regulation of transcription, DNA-dependent [a.k.a. RHE_CH03146, PF02518.9, InterPro:IPR001789]

Streptomyces coelicolor

SCO3641 - SCH10.19c, probable two-component system sensor kinase, len: 459 aa; similar to many e.g. TR:Q53893 (EMBL:U51332), AbsA1, Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa), fasta scores; opt: 332 z-score: 342.7 E(): 8.9e-12, 30.6% identity in 402 aa overlap. Contains hydrophobic, probable membrane-spanning regions. Similar to many other two-component system sensor kinases from Streptomyces coelicolor e.g. TR:O86631 (EMBL:AL031155) SC3A7.30, probable two-component system sensor (429 aa) (36.2% identity in 409 aa overlap). [...] [a.k.a. SCH10.19c, NP_627835.1, Q9X8Q8]

Burkholderia pseudomallei K96243

BPSS1495 - Putative two-component regulator sensor kinase; Similar to Pseudomonas aeruginosa probable two-component sensor pa2571 SWALL:Q9I0R5 (EMBL:AE004685) (470 aa) fasta scores: E(): 4.9e-11, 26.43% id in 401 aa, and to Chlorobium tepidum sensor histidine kinase/response regulator ct1396 SWALL:AAM72624 (EMBL:AE012897) (808 aa) fasta scores: E(): 2.1e-06, 29.09% id in 409 aa, and to Anabaena sp. two-component hybrid sensor and regulator alr1968 SWALL:Q8YVK7 (EMBL:AP003587) (759 aa) fasta scores: E(): 2.3e-06, 29.8% id in 312 aa [a.k.a. CAH38968.1, CAH38968, InterPro:IPR007895]

Rhodopirellula baltica

RB12326 - Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16 [a.k.a. NP_870445.1, GI:32477451, Q7UIU0]

Rhodopirellula baltica

RB7308 - Sensory box sensor histidine kinase; PMID: 20406833 best DB hits: BLAST: pir:H83285; probable two-component sensor PA2882 [imported] -; E=2e-36 pir:F83324; probable two-component sensor PA2571 [imported] -; E=3e-36 pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=7e-34 COG: PA2882; COG0642 Sensory transduction histidine kinases; E=2e-37 PFAM: PF00785; PAC motif; E=5.1e-05 PF00512; His Kinase A (phosphoacceptor); E=0.0012 PF02518; Histidine kinase-, DNA gyrase B; E=5.2e-32 [a.k.a. NP_867755.1, Sensory box sensor histidine kinase, sensory box sensor histidine kinase]

Ktedonobacter racemifer

Krac_7732 - Uncharacterized protein; KEGG: cvi:CV_0896 two-component sensor; SPTR: Q7NZM6 Probable two-component sensor [a.k.a. EFH86434.1, EFH86434, WP_007910738.1]

Rhizobium etli CFN42

ABC89213.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Similar to Atu0343 [Agrobacterium tumefaciens str. C58]; Similar to swissprot:Q8UIF4; Putative location:bacterial inner membrane Psort-Score: 0.4524; Protein involved in ATP binding, kinase activity, DNA binding, two-component sensor molecule activity, signal transducer activity, two-component response regulator activity, regulation of transcription, DNA-dependent, signal transduction and two-component signal transduction system (phosphorelay) [a.k.a. RHE_CH00391, PF02518.9, Q2KD73]

Rhodococcus jostii

ABG94726.1 - Probable response regulator; Protein involved in two-component sensor activity, two-component response regulator activity, DNA binding, ATP binding, two-component signal transduction system (phosphorelay) and protein amino acid phosphorylation [a.k.a. RHA1_ro02921, Probable response regulator, ABG94726]

Rhizobium etli CFN42

RHE_CH03320 - Probable two-component response regulator protein; Similar to SMb20609 [Sinorhizobium meliloti]; Similar to swissprot:Q92TJ2; Putative location:bacterial inner membrane Psort-Score: 0.5161; Protein involved in ATP binding, transcription factor activity, kinase activity, DNA binding, two-component sensor molecule activity, two-component response regulator activity, nucleobase transporter activity, regulation of transcription, DNA-dependent, signal transduction, two-component signal transduction system (phosphorelay) and nucleobase, nucleoside, nucleotide and nucleic acid transport [a.k.a. RHE_CH03320, PF02518.9, PF00512.10]

Streptomyces coelicolor

SCO6421 - SC1A6.10, probable two-component system sensor kinase, len: 382 aa; N-terminus (~1-150 aa) contains six potential transmembrane domains, C-terminus is similar to e.g. SW:UHPB_ECOLI (P09835) Escherichia coli sensor protein UhpB (500 aa), fasta scores; opt: 151 z-score: 290.1 E(): 4.9e-09, 28.3% identity in 314 aa overlap and to many Streptomyces coelicolor two-component system sensor kinases, e.g. TR:Q9S2S0 (EMBL:AL09687) two-component system sensor kinase SC5F7.35c, 416 aa; fasta scores: opt: 525 Z-score: 546.5 E(): 8.3e-23; 40.489% identity in 368 aa overlap. Contains possible hydroph [...] [a.k.a. SC1A6.10, NP_630507.1, 1101860]

Rhizobium etli CIAT652

ACE89923.1 - Probable two-component sensor histidine kinase protein; Ypch00315; Protein involved in two-component response regulator activity, two-component signal transduction system (phosphorelay and regulation of transcription, DNA-dependent [a.k.a. RHECIAT_CH0000938, 190695838, InterPro:IPR001789]

Campylobacter jejuni NCTC11168

Cj1492c - Putative two-component sensor; Original (2000) note: Cj1492c, probable two-component sensor, len: 403 aa; similar to many e.g. KINC_BACSU sporulation kinase C (428 aa), fasta scores; opt: 281 z-score: 301.1 E(): 1.9e-09, 29.3% identity in 242 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet,so putative kept within product function. Functional classification - Signal transduction [a.k.a. CAL35599.1, InterPro:IPR013655, AII25149]

Yersinia pestis CO92

YPO2916 - Two-component system sensor kinase; Similar to Streptomyces coelicolor and Streptomyces lividans two-component sensor kinase involved in copper metabolism CutS SW:CUTS_STRCO (Q03757) (414 aa) fasta scores: E(): 3.9e-14, 30.0% id in 300 aa, and to Escherichia coli probable sensor protein YfhK SW:YFHK_ECOLI (P52101) (496 aa) fasta scores: E(): 0, 71.9% id in 474 aa. Probable two-component system histidine sensor kinase [a.k.a. CAL21525.1, Q7CJP8, InterPro:IPR003661]

Mycobacterium tuberculosis H37Rv

Rv2998A - Uncharacterized protein; Rv2998A, len: 67 aa. Probable conserved hypothetical protein, (possibly gene fragment), highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 two component sensor (fragment) from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 212, E(): 3.7e-09, (58.2% identity in 67 aa overlap); Q9L2B6|SC8F4.08 probable two-component sensor kinase from Streptomyces coelicolor (478 aa), FASTA scores: opt: 193,E(): 2.6e-07, (47.05% identity in 68 aa overlap); etc [a.k.a. CCP45804.1, Q6MX20, 444896543]

Streptomyces coelicolor

SCO3818 - SCGD3.19, probable two-component system transcriptional regulator, len: 218 aa; similar to many two-component system regulators e.g. TR:O85372 (EMBL:AF064700), CprR, Rhodococcus sp. two-component system component controlling expression of an emulsion-stabilizing capsule (212 aa), fasta scores; opt: 807 z-score: 938.9 E(): 0, 60.7% identity in 211 aa overlap, but doesn't have a directly adjacent sensor kinase. Similar to many from S.coelicolor e.g. (EMBL:AL049754), SCH10.18c, probable two-component system regulator (228 aa) (42.2% identity in 211 aa overlap). Contains probable helix-tur [...] [a.k.a. SCGD3.19, NP_628007.1, Q9XA59_STRCO]

Yersinia enterocolitica 8081

YE4185 - Probable two-component sensor kinase; Similar to Rhizobium loti two-component c4-dicarboxylate transport system, sensor protein mlr7238 SWALL:Q986R7 (EMBL:AP003011) (601 aa) fasta scores: E(): 4.4e-21, 34.82 38d in 224 aa, and to Rhizobium meliloti sensor protein fixl fixl or ra0670 or sma1229 SWALL:FIXL_RHIME (SWALL:P10955) (505 aa) fasta scores: E(): 4.8e-17, 31.48 38d in 235 aa [a.k.a. CAL14201.1, A1JT98, 122091315]

Streptomyces coelicolor

SCO5404 - SC8F4.08, probable two-component sensor kinase, len: 478 aa; similar to many proposed two-component sensor kinases eg. SW:P18392 (RSTB_ECOLI) sensor protein RstB from Escherichia coli (433 aa) fasta scores; opt: 379, z-score: 410.8, E(): 1.8e-15, 35.6% identity in 239 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and Pfam match to entry PF00512 signal, Histidine kinase [a.k.a. SC8F4.08, NP_629543.1, two-component sensor kinase]

Rhizobium leguminosarum WSM2304

Rleg2_5340 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: ret:RHE_PF00310 probable two-component sensor histidine kinase protein [a.k.a. ACI58520.1, IPR013727, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_3342 - Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: ret:RHE_CH03588 probable two-component sensor histidine kinase protein [a.k.a. ACI56609.1, IPR013727, WP_003585845.1]

Kitasatospora setae

KSE_43580 - Putative two-component system sensor kinase; Similar to Probable two component sensor kinase mprB in Mycobacterium tuberculosis (O53895) [a.k.a. BAJ30141.1, WP_014137441.1, Putative two-component system sensor kinase]

Rhodococcus jostii

ABG99005.1 - Probable membrane protein; Protein involved in two-component sensor activity and two-component signal transduction system (phosphorelay) [a.k.a. RHA1_ro07241, 4224791, 110823721]

Rhizobium etli CFN42

ABC90057.1 - Probable two-component sensor histidine kinase protein; Similar to AGR_C_1677p [Agrobacterium tumefaciens]; Similar to swissprot:Q8UGW4; Putative location:bacterial inner membrane Psort-Score: 0.3569; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, regulation of transcription, DNA-dependent, signal transduction and two-component signal transduction system (phosphorelay) [a.k.a. RHE_CH01252, PF02518.9, PF00512.10]

Streptomyces coelicolor

SCO6163 - Histidine kinase; SC1A9.27c, probable sensor kinase, len: 303aa; similar to a family of sensor kinases eg. TR:O69960 (EMBL:AL022268) probable two-component sensor protein from Streptomyces coelicolor (358 aa) fasta scores; opt:1037, z-score: 1477.8, E():0, (59.2% identity in 299 aa overlap) and TR:Q52558 (EMBL:U02041) two-component sensor regulating virulence genes of Pseudomonas solanacearum (502 aa) fasta scores; opt: 388, z-score: 475.5, E():3.3e-19, (31.5% identity in 270 aa overlap). Contains possible hydrophobic membrane spanning regions [a.k.a. SC1A9.27c, NP_630268.1, Q9ZBS5_STRCO]

Xanthomonas albilineans

envZ - Probable two-component system sensor protein, osmolarity sensor protein envz; Transcriptional level go:0006355; two-component regulatory systems (external signal) go:0000155 go:0000156 [a.k.a. XALc_0859, CBA15377.1, XALC_0859]

Rhizobium etli CFN42

ABC90102.1 - Probable two-component sensor histidine kinase protein; Similar to SMc02369 [Sinorhizobium meliloti] and pleC (Atu0982) [Agrobacterium tumefaciens str. C58]; Similar to swissprot:Q92R85; Putative location:bacterial inner membrane Psort-Score: 0.3675; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity, regulation of transcription, DNA-dependent, signal transduction and two-component signal transduction system (phosphorelay) [a.k.a. RHE_CH01297, PF02518.9, GI:86281039]

Rhizobium etli CFN42

ABC89442.1 - Probable two-component sensor histidine kinase protein; Similar to aphB (all2899) [Nostoc sp. PCC 7120]; Similar to entrez-protein:Q9R6X3; Putative location:bacterial inner membrane Psort-Score: 0.3781; Protein involved in ATP binding, kinase activity, transferase activity, two-component sensor molecule activity, signal transducer activity, G-protein coupled photoreceptor activity, regulation of transcription, DNA-dependent, signal transduction, sensory perception, two-component signal transduction system (phosphorelay), red, far-red light phototransduction and vision [a.k.a. RHE_CH00626, PF02518.9, PF00512.10]

Thermus sp. CCBUS3UF1

AEV15839.1 - Two-component sensor; Similar to Signal transduction histidine kinase COG4585; similar to Probable two-component sensor of Thermus thermophilus HB27 UniRef RepID=Q72LA1_THET2 [a.k.a. TCCBUS3UF1_7910, thc:TCCBUS3UF1_7910, G8NBE9_9DEIN]

Streptomyces coelicolor

SCO7649 - SC10F4.22c, probable two-component system sensor kinase, len: 398 aa; similar to many other Streptomyces coelicolor sensor kinases, e.g. TR:Q9RKT9 (EMBL:AL132824) two-component sensor kinase SCAH10.18, 417 aa; fasta scores: opt: 780 z-score: 815.5 E(): 0; 44.0% identity in 348 aa overlap. Contains possible hydrophobic membrane spanning regions in the N-terminal domain [a.k.a. SC10F4.22c, NP_631689.1, Q9F3N8_STRCO]

Xanthomonas albilineans

XALc_2599 - Probable two-component system sensor protein; Transcriptional level go:0006355; two-component regulatory systems (external signal) go:0000155 go:0000156 [a.k.a. XALC_2599, CBA17078.1, xal:XALC_2599]

Rhizobium etli CFN42

ABC93301.1 - Probable serine/threonine kinase protein with two-component sensor domain; Similar to hstK (alr2258) [Nostoc sp. PCC 7120]; Similar to swissprot:Q9L708; Putative location:bacterial inner membrane Psort-Score: 0.1044; Protein involved in ATP binding, kinase activity, transferase activity, two-component sensor molecule activity, signal transducer activity, protein kinase activity, protein serine/threonine kinase activity, regulation of transcription, DNA-dependent, signal transduction, sensory perception, two-component signal transduction system (phosphorelay) and protein amino acid phos [...] [a.k.a. RHE_PC00094, PF02518.9, IPR003018]

Streptomyces coelicolor

SCO5824 - SC5B8.14, probable two-component sensor, len: 384 aa; N-termius has six possible transmembrane domains, C-terminus is similar to histidine kinase domain of many two-component sensors e.g. NARQ_ECOLI P27896 nitrate/nitrite sensor (566 aa) fasta scores; opt: 220 z-score: 227.4 E(): 1.8e-0 5, 32.3% identity in 198 aa overlap. Contains possible hydrophobic membrane spanning regions [a.k.a. SC5B8.14, NP_629947.1, O70000]

Paracoccus denitrificans

Pden_0311 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; Two-component sensor kinase N-terminal domain protein; KEGG: ret:RHE_CH03588 probable two-component sensor histidine kinase protein [a.k.a. ABL68425.1, A1AYT1_PARDP, IPR013727]

Streptomyces coelicolor

SCO3639 - SCH10.17c, probable two-component system sensor kinase, len: 472 aa; similar to many e.g. TR:Q53893 (EMBL:U51332), AbsA1, Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa), fasta scores; opt: 370 z-score: 410.4 E(): 1.5e-15, 29.6% identity in 375 aa overlap. Also similar to SW:NARX_ECOLI (EMBL:X13360), NarX, NarR, Escherichia coli nitrate/nitrite sensor protein (598 aa) (28.5% identity in 228 aa overlap). Contains hydrophobic, probable membrane-spanning regions. Similar to many other two-component system sensor kinases fro [...] [a.k.a. SCH10.17c, NP_627833.1, GI:21222054]

Streptomyces coelicolor

SCO3654 - SCH10.32c, probable two-component system sensor kinase, len: 441 aa; similar to many e.g. TR:Q53893 (EMBL:U51332), AbsA1, Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa), fasta scores; opt: 474 z-score: 452.1 E(): 7.2e-18, 32.8% identity in 381 aa overlap. Also similar to SW:NARX_ECOLI (EMBL:X13360), NarX, NarR, Escherichia coli nitrate/nitrite sensor protein (598 aa) (28.2% identity in 234 aa overlap). Contains hydrophobic, probable membrane-spanning regions. Similar to many other two-component system sensor kinases fro [...] [a.k.a. SCH10.32c, NP_627848.1, Q9X8S1]

Rhodococcus jostii

ABG96130.1 - Probable conjugal transfer protein; Tc: 3.A.7; Protein involved in two-component sensor activity, ATP binding, two-component signal transduction system (phosphorelay) and transport [a.k.a. RHA1_ro04340, rha:RHA1_ro04340, 4221891]

Xanthomonas albilineans

phoQ - Probable two-component system sensor protein phoq; Transcriptional level go:0006355; two-component regulatory systems (external signal) go:0000155 go:0000156 [a.k.a. XALc_0246, CBA14791.1, XALC_0246]

Xanthomonas albilineans

phoR - Probable two-component system sensor protein phor; Transcriptional level go:0006355; two-component regulatory systems (external signal) go:0000155 go:0000156 [a.k.a. XALc_0574, XALC_0574, CBA15103.1]

Streptomyces coelicolor

SCO4155 - SCD84.22c, probable two-component system sensor, len: 481 aa; similar to TR:O53895 (EMBL:AL021999) Mycobacterium tuberculosis two-component sensor, MTV044.10, 504 aa; fasta scores: opt: 884 z-score: 949.8 E(): 0; 39.4% identity in 482 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-), 535 aa; fasta scores: opt: 404 z-score: 435.9 E(): 8e-17; 31.4% identity in 526 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase and correctly situated match to P [...] [a.k.a. SCD84.22c, NP_628332.1, two-component system sensor]

Burkholderia pseudomallei K96243

BPSL0774 - Similar to Ralstonia solanacearum probable transmembrane sensor histidine kinase transcription regulator protein rsc0549 or rs04917 SWALL:Q8Y1Y8 (EMBL:AL646059) (513 aa) fasta scores: E(): 3.9e-104, 58.77% id in 507 aa, and to Ralstonia solanacearum probable two-component transmembrane sensor kinase transcription regulator protein rsc1735 or rs02923 SWALL:Q8XYM3 (EMBL:AL646066) (471 aa) fasta scores: E(): 2e-49, 37.69% id in 451 aa, and to Rhizobium loti two-component system, sensor protein mll7952 SWALL:Q984L4 (EMBL:AP003013) (452 aa) fasta scores: E(): 9.4e-48, 38.28% id in 444 aa [a.k.a. CAH34766.1, WP_004526207.1, IPR013727]

Rhodococcus jostii

ABG92120.1 - Probable conserved signalling protein; Protein involved in two-component sensor activity, molecular function unknown and two-component signal transduction system (phosphorelay) [a.k.a. RHA1_ro00284, Q0SK16, ABG92120]

Burkholderia cenocepacia

BCAM0229 - Two-component regulatory system, sensor kinase protein; C terminus is similar to C terminus Chromobacterium violaceum probable two-component sensor (ec 2.7.3.-). UniProt:Q7NVL8 (417 aa) fasta scores: E()=3.3e-20, 36.290% id in 248 aa [a.k.a. CAR54087.1, InterPro:IPR003661, InterPro:IPR009082]

Rhodopirellula baltica

RB9428 - Probable two-component sensor histidine kinase VicK; Best DB hits: BLAST: embl:CAB64973.1; (AJ012050) VicK protein [Enterococcus faecalis]; E=2e-15 pir:C72228; sensor histidine kinase HpkA - Thermotoga maritima; E=5e-15 ddbj:BAB05664.1; (AP001513) two-component sensor histidine kinase; E=5e-15 COG: TM1654_2; COG0642 Sensory transduction histidine kinases; E=5e-16 PFAM: PF00193; Extracellular link domain; E=0.19 PF00512; His Kinase A (phosphoacceptor) doma; E=2.9e-16 PF02518; Histidine kinase-, DNA gyrase B-, p; E=6.3e-27 [a.k.a. NP_868880.1, 32475886, Two-component sensor histidine kinase VicK]

Streptomyces coelicolor

SCO5683 - SC5H4.07, probable two-component system sensor kinase, len: 398 aa; similar to TR:Q9X851 (EMBL:AL049630) Streptomyces coelicolor two-component sensor kinase SCE126.08c, 401 aa; fasta scores: opt: 581 z-score: 640.5 E(): 3.2e-28; 36.8% identity in 361 aa overlap and to TR:BAA88406 (EMBL:AB016841) Streptomyces thermoviolaceus ChiS protein, 448 aa; fasta scores: opt: 445 z-score: 491.3 E(): 6.6e-20; 34.5% identity in 391 aa overlap. Contains possible hydrophobic membrane spanning regions in N-terminal domain [a.k.a. SC5H4.07, NP_629811.1, Q9KYT2_STRCO]

Burkholderia pseudomallei K96243

BPSL1365 - Putative phosphate regulon two-component system sensor kinase; Similar to Escherichia coli phosphate regulon sensor protein PhoR or NmpB or b0400 SWALL:PHOR_ECOLI (SWALL:P08400) (431 aa) fasta scores: E(): 1.5e-50, 36.83% id in 429 aa, and to Ralstonia solanacearum probable phosphate regulon two-component sensor kinase transcription regulator protein rsc1535 or rs03768 SWALL:Q8XZ69 (EMBL:AL646065) (443 aa) fasta scores: E(): 1.5e-104, 61.89% id in 433 aa [a.k.a. CAH35363.1, 3093459, GI:52209418]

Rhizobium etli CFN42

ABC89660.1 - Probable two-component sensor histidine kinase protein; Similar to Atu0700 [Agrobacterium tumefaciens str. C58]; Similar to swissprot:Q8UHI2; Putative location:bacterial inner membrane Psort-Score: 0.1086; Protein involved in kinase activity, DNA binding, signal transducer activity, two-component response regulator activity, regulation of transcription, DNA-dependent, signal transduction and two-component signal transduction system (phosphorelay) [a.k.a. RHE_CH00849, 86280597, Q8UHI2]

Caldithrix abyssi

Cabys_1495 - PFAM: His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR000014:IPR003661:IPR013767; KEGG: cvi:CV_2324 two-component sensor; PFAM: PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: PAS; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Probable two-component sensor; TIGRFAM: PAS [a.k.a. Calab_2659, EHO42269.1, APF18244]

Oceanithermus profundus

Ocepr_1005 - Histidine kinase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594: IPR005467: IPR011712; KEGG: tth:TTC0158 two-component sensor; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: ATP-binding region ATPase domain protein; SPTR: Probable two-component sensor; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [a.k.a. ADR36462.1, opr:Ocepr_1005, 313152611]

Rhizobium etli CFN42

ABC91190.1 - Probable two-component sensor histidine kinase protein; Similar to SMb20218 [Sinorhizobium meliloti]; Similar to swissprot:Q92WW6; Putative location:bacterial inner membrane Psort-Score: 0.4121; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH02412, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC91218.1 - Probable two-component sensor histidine kinase protein; Similar to SMc04212 [Sinorhizobium meliloti]; Similar to swissprot:Q92P99; Putative location:bacterial inner membrane Psort-Score: 0.3421; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity and signal transduction [a.k.a. RHE_CH02441, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC91776.1 - Probable two-component sensor histidine kinase protein; Similar to SMc01595 [Sinorhizobium meliloti]; Similar to swissprot:Q92N80; Putative location:bacterial inner membrane Psort-Score: 0.5012; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity, phosphoinositide phospholipase C activity, signal transduction, intracellular signaling cascade and lipid metabolism [a.k.a. RHE_CH03009, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC92191.1 - Probable two-component sensor histidine kinase protein; Similar to SMb21201 [Sinorhizobium meliloti]; Similar to swissprot:Q92V51; Putative location:bacterial inner membrane Psort-Score: 0.6710; Protein involved in ATP binding, kinase activity, transferase activity, two-component sensor molecule activity and signal transduction [a.k.a. RHE_CH03434, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC92343.1 - Probable two-component sensor histidine kinase protein; Similar to SMb20721 [Sinorhizobium meliloti]; Similar to swissprot:Q92TS1; Putative location:bacterial inner membrane Psort-Score: 0.4291; Protein involved in ATP binding, kinase activity, transferase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH03588, PF02518.9, UniProtKB/Swiss-Prot:Q92TS1]

Rhizobium etli CFN42

ABC93265.1 - Probable two-component sensor histidine kinase protein; Similar to RSp1454 [Ralstonia solanacearum]; Similar to swissprot:Q8XQ32; Putative location:bacterial inner membrane Psort-Score: 0.1765; Protein involved in ATP binding, kinase activity, transferase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_PC00058, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC88863.1 - Probable two-component sensor histidine kinase protein; Similar to AGR_C_44p [Agrobacterium tumefaciens] and SMc02756 [Sinorhizobium meliloti]; Similar to swissprot:Q8UJA1; Putative location:bacterial inner membrane Psort-Score: 0.4248; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH00030, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC89851.1 - Probable two-component sensor histidine kinase protein; Similar to AGR_C_1116p [Agrobacterium tumefaciens] and SMc02367 [Sinorhizobium meliloti]; Similar to swissprot:Q8UHQ2; Putative location:bacterial inner membrane Psort-Score: 0.4291; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH01042, PF02518.9, Q2KBD5]

Rhizobium etli CFN42

ABC90913.1 - Probable two-component sensor histidine kinase protein; Similar to Atu4781 [Agrobacterium tumefaciens str. C58] and SMa1142 [Sinorhizobium meliloti]; Similar to swissprot:Q8U6M6; Putative location:bacterial inner membrane Psort-Score: 0.6647; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH02129, PF02518.9, PF00512.10]

Rhizobium etli CFN42

ABC91350.1 - Probable two-component sensor histidine kinase protein; Similar to AGR_L_489p [Agrobacterium tumefaciens] and mll5372 [Mesorhizobium loti]; Similar to swissprot:Q8U717; Putative location:bacterial inner membrane Psort-Score: 0.3994; Protein involved in ATP binding, kinase activity, two-component sensor molecule activity, signal transducer activity and signal transduction [a.k.a. RHE_CH02576, PF02518.9, PF00512.10]

Burkholderia pseudomallei K96243

BPSL0703 - Putative two-component sensor histidine kinase; Similar to Xanthomonas campestris histidine kinase xcc1957 SWALL:AAM41246 (EMBL:AE012299) (408 aa) fasta scores: E(): 1.1e-42, 50.16% id in 297 aa, and to Xanthomonas axonopodis histidine kinase xac1991 SWALL:AAM36853 (EMBL:AE011834) (408 aa) fasta scores: E(): 1.3e-42, 49.49% id in 297 aa, and to Pseudomonas aeruginosa probable two-component sensor pa2571 SWALL:Q9I0R5 (EMBL:AE004685) (470 aa) fasta scores: E(): 1.4e-42, 46.93% id in 326 aa [a.k.a. CAH34696.1, YP_107332, InterPro:IPR003661]

Streptomyces coelicolor

SCO7089 - SC3A4.15c, probable two-component system sensor kinase, len: 397 aa. Highly similar to many including Escherichia coli SW:NARX_ECOLI (EMBL:X13360) nitrate/nitrite sensor protein NarX (598 aa), fasta scores opt: 211 z-score:0.0 E(): 0.0 28.82% identity in 229 aa overlap and Streptomyces coelicolor TR:CAB59719 (EMBL:AL132707) two-component sensor kinase, SCF51.21C (397 aa), fasta scores opt: 1075 z-score: 1237.2 E(): 0 48.0% identity in 400 aa overlap. Contains possible membrane spanning hydrophobic domains [a.k.a. SC3A4.15c, NP_631150.1, Two-component system sensor kinase]

Burkholderia pseudomallei K96243

BPSS1358 - Putative sensor kinase protein; Similar to Erwinia chrysanthemi regulator HrpX SWALL:AAM46691 (EMBL:AF448202) (450 aa) fasta scores: E(): 8.4e-24, 28.46% id in 390 aa, and similar to the C-terminus of Pseudomonas aeruginosa probable two-component sensor pa0600 from codon 129 SWALL:Q9I5T8 (EMBL:AE004496) (797 aa) fasta scores: E(): 1.2e-36, 38.79% id in 366 aa, and to similar to the C-terminus of Ralstonia solanacearum probable transmembrane two component system sensor kinase transcription regulator protein rsc0191 or rs00623 from codon 254 SWALL:Q8Y2Z0 (EMBL:AL646057) (458 aa) fasta sc [...] [a.k.a. CAH38829.1, InterPro:IPR001789, GI:52212797]

Myroides odoratus

Myrod_1423 - Integral membrane sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003594:IPR003661; KEGG: fps:FP2349 two-component system sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; SPTR: Probable two-component system sensor histidine kinase [a.k.a. EHQ42256.1, H1Z508, InterPro:IPR003661]

Thiomicrospira crunogena

Tcr_2180 - PAS/PAC sensor hybrid histidine kinase; KEGG: pae:PA3946 probable two-component sensor; TIGRFAM: PAS sensor protein; PFAM: extracellular solute-binding protein, family 3 response regulator receiver ATP-binding region, ATPase-like histidine kinase A-like; SMART: PAS [a.k.a. ABB42768.1, tcx:Tcr_2180, InterPro:IPR001789]

Dinoroseobacter shibae

Dshi_0516 - Putative two-component sensor kinase; Pfam04392, ABC_sub_bind, ABC transporter substrate binding protein; no significant swissprot; good Ref ZP hit to probable sensor histidine kinase of two-component system from Roseovarius sp. HTCC2601; unsure GC frame plot [a.k.a. ABV92262.1, dsh:Dshi_0516, GI:157910829]

Burkholderia phytofirmans

Bphyt_6236 - Multi-sensor signal transduction histidine kinase; KEGG: pae:PA0600 probable two-component sensor; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACD20563.1, InterPro:IPR001789, GI:187719340]

Pseudogulbenkiania ferrooxidans

EEG07125.1 - Multi-sensor hybrid histidine kinase; KEGG: cvi:CV_1951 probable two-component sensor; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. FuraDRAFT_3325, InterPro:IPR013656, InterPro:IPR001789]

Solibacter usitatus

Acid_7838 - Multi-sensor signal transduction histidine kinase; KEGG: pae:PA4036 probable two-component sensor; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; CHASE2 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ABJ88734.1, IPR007890, InterPro:IPR013656]

Rhizobium leguminosarum WSM2304

Rleg2_0497 - Putative PAS/PAC sensor protein; KEGG: rec:RHECIAT_CH0000938 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACI53794.1, InterPro:IPR013656, InterPro:IPR001789]

Xanthomonas albilineans

XALc_1303 - Probable two-component system sensor-response regulator hybrid protein; Transcriptional level go:0006355; two-component regulatory systems (external signal) go:0000155 go:0000156 [a.k.a. CBA15810.1, XALC_1303, GI:283473305]

Burkholderia pseudomallei K96243

BPSL0127 - Sensor kinase protein; Two-component regulatory system family, sensor kinase protein. Similar to Azorhizobium caulinodans nitrogen regulation protein NtrY SWALL:NTRY_AZOCA (SWALL:Q04850) (771 aa) fasta scores: E(): 2.7e-25, 26.65% id in 814 aa, and to Ralstonia solanacearum probable two component sensor histidine kinase transcription regulator protein rsc0077 or rs02275 SWALL:Q8Y3A3 (EMBL:AL646057) (811 aa) fasta scores: E(): 6.7e-118, 58.61% id in 824 aa [a.k.a. CAH34113.1, YP_106754, InterPro:IPR013656]

Pseudogulbenkiania ferrooxidans

EEG06678.1 - Multi-sensor signal transduction histidine kinase; KEGG: cvi:CV_0920 probable two-component transmembrane sensor; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. FuraDRAFT_3908, InterPro:IPR013656, WP_008955925.1]

Streptomyces coelicolor

SCO0203 - SCJ12.15c, probable two-component sensor. len: 585 aa. Similarity to Streptomyces coelicolor TR:Q9ZBY4 (EMBL; AL034355) two component sensor SCD78.15 (560 aa), fasta scores opt: 1439 z-score: 1571.0 E(): 0 44.7% identity in 553 aa overlap. Also some similarity to Pseudomonas aeruginosa TR:O54040 (EMBL; Y15252) nitrate/nitrite sensory protein NarX (622 aa), fasta scores opt: 315 z-score: 344.5 E(): 7.9e-1 29.0% identity in 297 aa overlap. Contains 2x Pfam match to entry PF01590 GAF and potential membrane spanning hydrophobic domains. Probable coiled-coil from 17 to 48 (32 residues) [a.k.a. SCJ12.15c, NP_624538.1, sco:SCO0203]

Burkholderia pseudomallei K96243

BPSL1983 - Putative two component system, histidine kinase; Similar to Pseudomonas aeruginosa probable two-component sensor pa4036 SWALL:Q9HWZ1 (EMBL:AE004820) (766 aa) fasta scores: E(): 1.4e-49, 39.2% id in 806 aa, and to Caulobacter crescentus sensory box histidine kinase, putative cc3327 SWALL:Q9A377 (EMBL:AE005994) (761 aa) fasta scores: E(): 1.3e-22, 35.7% id in 801 aa [a.k.a. CAH35982.1, IPR007890, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_0285 - Multi-sensor signal transduction histidine kinase; KEGG: rec:RHECIAT_CH0000702 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ACI53584.1, InterPro:IPR013656, rlt:Rleg2_0285]

Rhizobium leguminosarum WSM2304

Rleg2_0929 - Multi-sensor signal transduction histidine kinase; KEGG: rec:RHECIAT_CH0001392 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; SMART: PAC repeat-containing protein [a.k.a. ACI54223.1, InterPro:IPR003661, InterPro:IPR013655]

Rhizobium leguminosarum WSM2304

Rleg2_5459 - Multi-sensor signal transduction histidine kinase; KEGG: rec:RHECIAT_PC0000411 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; MASE1 domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ACI58637.1, WP_012556239.1, B6A203_RHILW]

Ralstonia pickettii 12J

Rpic_3592 - PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Osmosensitive K channel His kinase sensor; KEGG: rso:RSc3385 probable two-component sensor kinase KdpD transcription regulator protein [a.k.a. ACD28711.1, WP_012436775.1, 6287583]

Burkholderia phymatum

Bphy_7756 - PAS sensor protein; KEGG: ret:RHE_PC00094 probable serine/threonine kinase protein with two-component sensor domain; TIGRFAM: PAS sensor protein; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; serine/threonine protein kinase [a.k.a. ACC76642.1, B2JYD4_PARP8, InterPro:IPR013656]

Pelobacter propionicus

Ppro_3410 - PAS sensor protein; KEGG: ret:RHE_PC00094 probable serine/threonine kinase protein with two-component sensor domain; TIGRFAM: PAS sensor protein; PFAM: protein kinase; GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold domain protein; SMART: PAS domain containing protein; serine/threonine protein kinase [a.k.a. ABL01003.1, IPR003018, InterPro:IPR003439]

Fluviicola taffensis

Fluta_0548 - COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterPro IPR003852:IPR006016; KEGG: fps:FP1688 two-component system sensory protein; PFAM: Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal; UspA; SPTR: Probable two-component system sensory protein; PFAM: Osmosensitive K+ channel His kinase sensor domain; Universal stress protein family [a.k.a. AEA42553.1, F2IFU5, GI:327318061]

Mycobacterium ulcerans

senX3 - Membrane protein; sensor part of a two component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3 [a.k.a. MUL_4559, ABL06513.1, two component sensor histidine kinase SenX3]

Burkholderia pseudomallei K96243

BPSL2095 - Putative oxidative stress related two component system, sensor kinase; Similar to Escherichia coli osmolarity sensor protein EnvZ or OmpB or PerA or Tpo or b3404 SWALL:ENVZ_ECOLI (SWALL:P02933) (450 aa) fasta scores: E(): 7.8e-31, 32.3% id in 452 aa, and to Ralstonia solanacearum probable oxidative stress resistance two-component transmembrane sensor histidine kinase transcription regulator protein RisS or rsc1647 or rs04023 SWALL:Q8XYV9 (EMBL:AL646065) (453 aa) fasta scores: E(): 9.1e-95, 57.53% id in 438 aa [a.k.a. CAH36098.1, CAH36098, InterPro:IPR003661]

Burkholderia pseudomallei K96243

BPSL1037 - Putative two-component system, sensor kinase; Similar to Escherichia coli osmolarity sensor protein EnvZ or OmpB or PerA or Tpo or b3404 SWALL:ENVZ_ECOLI (SWALL:P02933) (450 aa) fasta scores: E(): 1.9e-24, 29.69% id in 431 aa, and to Ralstonia solanacearum probable two component transmembrane sensor kinase transcription regulator protein rsp1195 or rs03139 SWALL:Q8XQM7 (EMBL:AL646083) (431 aa) fasta scores: E(): 2.2e-59, 44.86% id in 428 aa [a.k.a. CAH35032.1, 3094648, InterPro:IPR003661]

Bacteroides fragilis NCTC 9343

CAH09827.1 - Putative two-component regulator sensor histidine kinase transcriptional regulator; C-terminus is similar to Escherichia coli O157:H7 sensor for Ctr capsule biosynthesis, probable histidine kinase acting on RcsB, RcsC or Z3477 or ECS3107 (from codon 418-670) SWALL:Q8XE39 (EMBL:AE005454) (933 aa) fasta scores: E(): 1.5e-07, 25.86% id in 259 aa, and to Bacteroides thetaiotaomicron putative two-component system sensor histidine kinase BT2850 SWALL:Q8A3V4 (EMBL:AE016937) (517 aa) fasta scores: E(): 1.1e-138, 73.06% id in 516 aa [a.k.a. BF9343_4046, bfs:BF9343_4046, GI:60495009]

Ehrlichia ruminantium

ntrY - Nitrogen regulation protein NtrY; Probable histidine kinase sensor component of a two-component regulatory system | len: 710 aa | Similar to many e.g. YYCG_BACSU Q45614 Sensor protein yycG (611 aa) from Bacillus subtilis, fasta scores: E(): 3.3e-12, 22.636% identity in 645 aa overlap | Contains Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase and PF00672 HAMP, HAMP domain | Contains 5 probable transmembrane helices predicted by TMHMM2.0 at aa 20-42, 57-79, 96-118, 289-311 and 383-405 | N [...] [a.k.a. ERWE_CDS_07310, CAH58428.1, Erum6960]

Azoarcus sp. BH72

azo0263 - Probable two-component system histidine kinase; Probable sensor protein,; High confidence in function and specificity [a.k.a. CAL92880.1, azo:azo0263, InterPro:IPR003661]

Yersinia pestis CO92

YPO2997 - Putative two-component system sensor kinase; Similar to Escherichia coli sensor protein BaeS SW:BAES_ECOLI (P30847) (467 aa) fasta scores: E(): 6.7e-19,26.3% id in 480 aa, and to Neisseria meningitidis sensor histidine kinase NMB0594 TR:Q9K0K1 (EMBL:AE002415) (468 aa) fasta scores: E(): 2.2e-31, 30.2% id in 463 aa. Probable histidine kinase protein of a two-component system [a.k.a. CAL21601.1, Putative two-component system sensor kinase, InterPro:IPR003661]

Psychrobacter arcticus

envZ - Probable signal transduction histidine kinase sensor; Two-component osmolarity sensor [a.k.a. Psyc_2020, AAZ19867.1, Q4FQ41_PSYA2]

Streptomyces coelicolor

SCO3062 - SCE25.03c, probable two-component system histidine kinase, len: 424 aa; similar to TR:O86661 (EMBL:AL031182) Streptomyces coelicolor two-component sensor SC4A2.05, 436 aa; fasta scores: opt: 486 z-score: 535.4 E(): 2.3e-22; 31.8% identity in 450 aa overlap. Contains Pfam match to entry PF00512 signal, Histidine kinase. Contains possible hydrophobic membrane spanning regions [a.k.a. SCE25.03c, NP_627282.1, GI:21221503]

Ralstonia pickettii 12J

Rpic_2020 - Multi-sensor signal transduction histidine kinase; KEGG: rso:RSc1535 probable phosphate regulon two-component sensor kinase transcription regulator protein; TIGRFAM: phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: PAS domain containing protein [a.k.a. ACD27154.1, InterPro:IPR003661, IPR005467]

Rhizobium leguminosarum WSM2304

Rleg2_0381 - KEGG: rec:RHECIAT_CH0000804 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACI53680.1, ACI53680, 209533745]

Rhizobium leguminosarum WSM2304

Rleg2_5151 - KEGG: ret:RHE_PE00175 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ACI58357.1, InterPro:IPR013656, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_5262 - Signal transduction histidine kinase; KEGG: rec:RHECIAT_PB0000073 probable two-component sensor histidine kinase protein; TIGRFAM: PAS sensor protein; PFAM: HWE histidine kinase; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACI58451.1, InterPro:IPR013656, InterPro:IPR013655]

Streptomyces coelicolor

SCO6424 - Histidine kinase; SC1A6.13c, probable two-component system sensor protein, len: 331 aa; contains two potential transmembrane domains in the C-terminus; similar to e.g. DEGS_BACSU P13799 sensor protein DegS (EC 2.7.3.-) Bacillus subtilis (385 aa), fasta scores: opt: 316 z-score: 369.3 E(): 1.9e-13, 30.7% identity in 212 aa overlap and to TR:Q52558 (EMBL:U02041) Burkholderia solanacearum VrsA, 502 aa; fasta scores: opt: 398 Z-score: 416.9 E(): 1.4e-15; 31.724% identity in 290 aa overlap. Contains possible hydrophobic membrane spanning regions [a.k.a. SC1A6.13c, NP_630510.1, NP_630510]

Ralstonia pickettii 12J

Rpic_3777 - PAS/PAC sensor hybrid histidine kinase; KEGG: rso:RS02235 probable composite two-component regulatory (sensor kinase and response regulator hybrid) transcription regulator protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACD28893.1, InterPro:IPR013656, InterPro:IPR001789]

Thiothrix nivea

Thini_4438 - Putative signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: bbr:BB2739 two-component sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; SPTR: Probable two component sensor histidine kinase transcription regulator protein [a.k.a. EIJ36916.1, 386423081, putative signal transduction histidine kinase]

Burkholderia pseudomallei K96243

BPSS2246 - Histidine kinase; Similar to Anabaena sp. two-component hybrid sensor and regulator alr3442 SWALL:Q8YRK4 (EMBL:AP003593) (865 aa) fasta scores: E(): 1.3e-49, 30.58% id in 680 aa, and to Ralstonia solanacearum probable composite two-component regulatory rsp1676 or rs02235 SWALL:Q8XPG5 (EMBL:AL646086) (796 aa) fasta scores: E(): 1e-42, 32.65% id in 640 aa [a.k.a. CAH39732.1, UniProtKB/TrEMBL:Q63I23, InterPro:IPR013656]

Burkholderia pseudomallei K96243

BPSS1794 - Uncharacterized protein; Similar to parts of Ralstonia solanacearum probable composite two-component regulatory rsp1676 or rs02235 SWALL:Q8XPG5 (EMBL:AL646086) (796 aa) fasta scores: E(): 1e-19, 34.13% id in 249 aa, and of Anabaena sp. two-component hybrid sensor and regulator alr3442 SWALL:Q8YRK4 (EMBL:AP003593) (865 aa) fasta scores: E(): 3.8e-13, 29.43% id in 248 aa [a.k.a. CAH39270.1, InterPro:IPR003661, GI:52213227]

Burkholderia cenocepacia

BCAM0289 - Two-component regulatory system, sensor kinase protein; Similar to Xanthomonas campestris (pv. campestris) hrpx hrpx related protein. UniProt:Q8P9A6 (697 aa) fasta scores: E()=7.1e-23, 27.436% id in 667 aa, and C terminus is similar to Ralstonia solanacearum (Pseudomonas solanacearum) rs00623 probable transmembrane two component system sensor kinase transcription regulator protein (ec 2.7.-.-). UniProt:Q8Y2Z0 (458 aa) fasta scores: E()=8.9e-64, 49.438% id in 445 aa [a.k.a. CAR54148.1, GI:198038195, IPR001610]

Ralstonia pickettii 12J

Rpic_4200 - Multi-sensor hybrid histidine kinase; KEGG: rso:RS05068 probable composite two-component transcriptional regulatory (sensor histidine kinase and response regulator hybrid) transcription regulator protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein [a.k.a. ACD29297.1, InterPro:IPR013656, InterPro:IPR001789]

Burkholderia pseudomallei K96243

BPSS1605 - Probable two-component system sensor kinase; Similar to Deinococcus radiodurans sensor histidine kinase dr1606 SWALL:Q9RTZ2 (EMBL:AE002004) (433 aa) fasta scores: E(): 4.8e-10, 30.22% id in 354 aa [a.k.a. CAH39080.1, probable two-component system sensor kinase, GI:52213042]

Rhodopirellula baltica

RB4994 - Osmolarity sensor protein envZ; PMID: 8063417 best DB hits: BLAST: pir:C83500; probable two-component sensor PA1158 [imported] -; E=6e-33 gb:AAG56596.1; AE005384_6 (AE005384) sensor histidine protein; E=2e-27 swissprot:P18392; RSTB_ECOLI SENSOR PROTEIN RSTB ----- pir:; E=2e-27 COG: PA1158; COG0642 Sensory transduction histidine kinases; E=6e-34 PFAM: PF00672; HAMP domain; E=8.4e-08 PF00512; His Kinase A (phosphoacceptor) doma; E=1.1e-15 PF02518; Histidine kinase-, DNA gyrase B-, p; E=1.2e-31 [a.k.a. NP_866446.1, NP_866446, osmolarity sensor protein envZ]

Chelativorans sp. BNC1

Meso_1904 - Histidine kinase; KEGG: ret:RHE_PE00024 probable two-component sensor histidine kinase/response regulator hybrid protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver ATP-binding region, ATPase-like histidine kinase A-like PAS fold-3 PAS fold-4 PAS fold; SMART: PAS PAC motif [a.k.a. ABG63297.1, IPR001680, InterPro:IPR013656]

Clostridium cellulovorans

ADL53511.1 - Multi-sensor signal transduction histidine kinase; KEGG: bbe:BBR47_06780 probable two-component sensor histidine kinase; PFAM: histidine kinase internal region; histidine kinase HAMP region domain protein; Cache domain protein; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein [a.k.a. Clocel_3841, 0004871, IPR005467]

Rhizobium leguminosarum WSM2304

Rleg2_1961 - Histidine kinase; KEGG: rec:RHECIAT_CH0002423 probable two-component sensor histidine kinase/response regulator hybrid protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein [a.k.a. ACI55246.1, InterPro:IPR013656, 209535311]

Rhizobium leguminosarum WSM2304

Rleg2_2892 - Histidine kinase; KEGG: ret:RHE_CH03146 probable two-component sensor histidine kinase/response regulator hybrid protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. ACI56160.1, InterPro:IPR013656, InterPro:IPR001789]

Rhodopirellula baltica

RB3779 - Putative histidine protein kinase; PMID: 10564511 best DB hits: BLAST: gb:AAD47812.1; (AF163841) histidine protein kinase; E=7e-40 pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=2e-38 pir:F83324; probable two-component sensor PA2571 [imported] -; E=2e-35 COG: VC1084; COG0642 Sensory transduction histidine kinases; E=2e-39 slr1759_2; COG2202 PAS/PAC domain; E=1e-18 BS_ykrQ_3; COG0642 Sensory transduction histidine kinases; E=1e-18 PFAM: PF00989; PAS domain; E=0.0067 PF00785; PAC motif; E=3.7e-09 PF00989; PAS domain; E=0.17 [a.k.a. NP_865720.1, Q7UTN1_RHOBA, NP_865720]

Pseudoxanthomonas suwonensis 111

Psesu_0554 - Multi-sensor signal transduction histidine kinase; KEGG: xal:XALc_0669 probable two-component system sensor protein pils; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein [a.k.a. ADV26412.1, InterPro:IPR003661, IPR005467]

Escherichia coli ATCC8739

pcoS - Probable sensor protein PcoS; Probable member of a two-component regulatory system PcoS/PcoR. May activate PcoR by phosphorylation [a.k.a. ACA79028.1, EcolC_3411, InterPro:IPR006290]

Campylobacter jejuni NCTC11168

Cj1226c - Histidine kinase; Original (2000) note: Cj1226c, probable two-component sensor (histidine kinase), len: 415 aa; similar to many sensor proteins e.g. CPXA_ECOLI sensor protein CPXA (457 aa), fasta scores; opt: 205 z-score: 241.7 E(): 3.7e-06, 25.2% identity in 270 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and two possible membrane spanning domains. Also similar to Cj1262 (31.0% identity in 410 aa overlap); Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motifs,PF00512 His Kin [...] [a.k.a. cprS, CAL35341.1, Putative two-component sensor (histidine kinase)]

Campylobacter jejuni NCTC11168

dccS - Original (2000) note: Cj1222c, probable two-component sensor (histidine kinase), len: 396 aa; similar to many sensor proteins e.g. RSTB_ECOLI sensor protein RSTB (433 aa), fasta scores; opt: 226 z-score: 267.7 E(): 1.3e-07, 24.5% identity in 237 aa overlap. 28.5% identity to HP1364. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, and two possible membrane spanning domains; Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motif and PF00512 His Kinase A (phosphoacceptor) domain were identified within CDS. Pros [...] [a.k.a. Cj1222c, CAL35337.1, AII24925]

Ehrlichia ruminantium

Erum2120 - Putative sensor protein; Possible histidine kinase sensor component of a two-component regulatory system | len: 477 aa | Similar to many e.g. Q9ZDU5 Histidine kinase sensor protein (BARA) (497 aa) from Rickettsia prowazekii, fasta scores: E(): 7.4e-45, 45.482% identity in 332 aa overlap | Contains Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase and PF00512 HisKA, His Kinase A (phosphoacceptor) domain | Contains 2 probable transmembrane helices predicted by TMHMM2.0 at aa 12-34 and 190-212. The initial transmembrane helix could represent a [...] [a.k.a. ERWE_CDS_02140, CAH57930.1, erw:ERWE_CDS_02140]

Streptomyces coelicolor

SCO6369 - Histidine kinase; SC4A2.05, probable two-component sensor, len: 436 aa; similar to many e.g. CUTS_STRLI CtS protein (414 aa), fasta scores; opt: 226 z-score: 309.1 E(): 5.8e-10, 32.9% identity in 316 aa overlap. Contains two probable transmembrane domains in the N-terminal half and Pfam matches to entry PF00672 DUF5, Domain found in bacterial signal proteins, score 42.70, E-value 8.2e-09 and to entry PF00512 signal, Signal carboxyl-terminal domain, score 38.00, E-value 1.7e-07 [a.k.a. SC4A2.05, NP_630460.1, 21224681]

Ralstonia pickettii 12J

Rpic_1948 - KEGG: rso:RSc1598 probable two-component transmembrane sensor histidine kinase transcription regulator protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ACD27083.1, InterPro:IPR013656, GI:187725918]

Pseudogulbenkiania ferrooxidans

EEG06807.1 - PAS/PAC sensor signal transduction histidine kinase; KEGG: cvi:CV_3089 probable two-component system; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein [a.k.a. FuraDRAFT_3711, IPR006189, InterPro:IPR013656]

Flavobacterium branchiophilum

CCB69427.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_1350, fbr:FBFL15_1350, GI:345529397]

Flavobacterium branchiophilum

CCB70082.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2052, CCB70082, fbr:FBFL15_2052]

Flavobacterium branchiophilum

CCB70143.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2113, G2Z2H4_FLABF, WP_014084605.1]

Flavobacterium branchiophilum

CCB70144.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2114, CCB70144, fbr:FBFL15_2114]

Flavobacterium branchiophilum

CCB70145.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2117, 345530115, G2Z7W6]

Flavobacterium branchiophilum

CCB70170.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2147, G2Z2J8_FLABF, fbr:FBFL15_2147]

Flavobacterium branchiophilum

CCB70237.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2217, CCB70237, 345530207]

Flavobacterium branchiophilum

CCB70281.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2261, fbr:FBFL15_2261, CCB70281]

Flavobacterium branchiophilum

CCB70449.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2442, fbr:FBFL15_2442, 345530419]

Flavobacterium branchiophilum

CCB70711.1 - Probable hybrid two-component system sensor histidine kinase and response regulator receiver; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2721, G2Z4Z3_FLABF, CCB70711]

Bacillus halodurans

dctS - Probable C4-dicarboxylate sensor kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation. Essential for expression of dctP (By similarity) [a.k.a. BH2752, BAB06471, 10175373]

Bacillus subtilis

dctS - Probable C4-dicarboxylate sensor kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP [a.k.a. ydbF, BSU04450, CAB12252.1]

Streptomyces coelicolor

SCO6362 - SC3A7.30, probable two-component sensor, len: 429 aa; similar to many e.g. UHPB_SALTY sensor protein UhpB (500 aa), fasta scores; opt: 238 z-score: 263.3 E(): 2.1e-07, 30.7% identity in 358 aa overlap. Contains six probable hydrophobic transmembrane domains in N-terminus [a.k.a. SC3A7.30, NP_630454.1, 21224675]

Streptomyces coelicolor

SCO1596 - SCI35.18c, probable two-component sensor, len: 379 aa; similar to many e.g. HYDH_ECOLI sensor protein hydH (465 aa), fasta scores; opt: 296 z-score: 418.4 E(): 4.6e-16, 35.4% identity in 257 aa overlap. No apparent transmembrane domains. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, score 205.10, E-value 1e-57 [a.k.a. SCI35.18c, NP_625872.1, 21220093]

Streptomyces coelicolor

SCO6353 - SC3A7.21c, probable two-component sensor, len: 459 aa; similar to many e.g. COPS_PSESM sensor protein copS (EC 2.7.3.-) (487 aa), fasta scores; opt: 310 z-score: 293.0 E(): 4.6e-09, 24.2% identity in 467 aa overlap. Contains a possible transmembrane domain near the N-terminus and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, score 113.70, E-value 3.5e-30 [a.k.a. SC3A7.21c, NP_630445.1, WP_011030850.1]

Mycobacterium tuberculosis H37Rv

narS - Probable sensor histidine kinase NarS; Probable member of the two-component regulatory system NarS/NarL. May activate NarL by phosphorylation [a.k.a. Rv0845, CCP43593.1, Probable sensor histidine kinase NarS]

Sphingobium japonicum UT26S

BAI96346.1 - Group 2 / glycosyltransferase, probably involved in cell wall biogenesis / two-component system sensor histidine kinase/response regulator, hybrid ('one component system') [a.k.a. SJA_C1-15120, D4Z164, WP_013039878.1]

Streptomyces coelicolor

SCO5784 - Histidine kinase; SC4H2.05, probable two-component sensor protein, len: 358 aa; similar to many e.g. DEGS_BACSU P13799 sensor protein DegS (ec 2.7.3.-), Bacillus subtilis (385 aa), fasta scores; opt: 317 z-score: 334.6 E(): 2e-11, 31.3% identity in 227 aa overlap. Contains possible hydrophobic membrane spanning regions [a.k.a. SC4H2.05, NP_629908.1, sco:SCO5784]

Dinoroseobacter shibae

Dshi_0515 - Histidine kinase; Unsure GC frame plot; - PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; NCBI conserved domains: HisKA; middle swissprot hit to Sensor protein fixL; good Ref ZP hit to probable sensor histidine kinase of two-component system from Roseovarius sp. HTCC2601 [a.k.a. ABV92261.1, GI:157910828, A8LNV3_DINSH]

Burkholderia pseudomallei K96243

BPSL0201 - Sensor kinase protein; Two-component regulatory system family, sensor kinase protein. Similar to Rhodobacter sphaeroides sensor histidine kinase RegB or PrrB SWALL:REGB_RHOSH (SWALL:Q53068) (462 aa) fasta scores: E(): 4.6e-22, 30.26% id in 423 aa, and to Ralstonia solanacearum probable transmembrane sensor histidine kinase transcription regulator protein rsc0039 or rs01862 SWALL:Q8Y3E1 (EMBL:AL646057) (448 aa) fasta scores: E(): 2.1e-49, 46.62% id in 429 aa [a.k.a. CAH34188.1, CAH34188, InterPro:IPR003661]

Streptomyces coelicolor

SCO5829 - SC5B8.19c, probable two-component sensor, len: 566 aa; similar to many e.g. CITA_KLEPN P52687 klebsiella pneumoniae sensor kinase (547 aa), fasta scores; opt: 604 z-score: 460.1 E(): 2e-18, 27.1% identity in 554 aa overlap. Contains Pfam match to entry signal PF00512, Signal C terminal domain, score 98.50. Contains possible hydrophobic membrane spanning regions [a.k.a. SC5B8.19c, NP_629952.1, O70005_STRCO]

Ralstonia pickettii 12J

Rpic_0469 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: rso:RSc0549 probable transmembrane sensor histidine kinase transcription regulator protein [a.k.a. ACD25624.1, GI:187724459, B2UGD7_RALPJ]

Delftia acidovorans

Daci_2754 - Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: rso:RSc0549 probable transmembrane sensor histidine kinase transcription regulator protein [a.k.a. ABX35392.1, IPR013727, InterPro:IPR003661]

Mycobacterium tuberculosis H37Rv

pdtaS - Probable sensor histidine kinase pdtaS; Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [a.k.a. Rv3220c, CCP46036.1, 2YKH]

Streptomyces coelicolor

SCO1259 - 2SCG18.06, probable two-component system sensor kinase, len: 384 aa; similar to TR:Q9ZBU9 (EMBL:AL034446) Streptomyces coelicolor sensor kinase SC1A9.03, 388 aa; fasta scores: opt: 377 z-score: 409.6 E(): 2.5e-15; 32.5% identity in 381 aa overlap and to TR:Q9Z678 (EMBL:AF102271) Streptomyces coelicolor sensor-histidine kinase, 398 aa; fasta scores: opt: 454 z-score: 491.8 E(): 6.6e-20; 38.0% identity in 287 aa overlap. Contains possible hydrophobic membrane spanning regions [a.k.a. 2SCG18.06, NP_625546.1, Putative two-component system sensor kinase]

Pseudogulbenkiania ferrooxidans

EEG10365.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: cvi:CV_0896 probable two-component sensor [a.k.a. FuraDRAFT_0347, 224604191, B9YZ12]

Polaromonas naphthalenivorans

Pnap_4085 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; KEGG: bbr:BB2739 probable two-component sensor histidine kinase [a.k.a. ABM39376.1, IPR005467, WP_011803438.1]

Ralstonia pickettii 12J

Rpic_3929 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: rso:RS05203 probable two-component transmembrane sensor histidine kinase transcription regulator protein [a.k.a. ACD29034.1, IPR005467, B2UHI3_RALPJ]

Solibacter usitatus

Acid_5085 - Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; PAS fold domain protein; KEGG: ret:RHE_PF00222 probable two-component sensor histidine kinase protein [a.k.a. ABJ86040.1, sus:Acid_5085, IPR005467]

Chthoniobacter flavus

EDY21996.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rba:RB9428 probable two-component sensor histidine kinase VicK [a.k.a. CfE428DRAFT_0121, InterPro:IPR003661, IPR005467]

Pseudogulbenkiania ferrooxidans

EEG09030.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: pap:PSPA7_4049 probable two-component sensor [a.k.a. FuraDRAFT_1790, B9Z377, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_0884 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0001348 probable two-component sensor histidine kinase protein [a.k.a. ACI54178.1, GI:209534243, B5ZVB9_RHILW]

Rhizobium leguminosarum WSM2304

Rleg2_2079 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0002542 probable two-component sensor histidine kinase protein [a.k.a. ACI55363.1, InterPro:IPR003661, B5ZSC2]

Paenibacillus lactis

EHB62426.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: bbe:BBR47_29950 probable two-component sensor histidine kinase [a.k.a. PaelaDRAFT_4169, G4HJH2, 0046983]

Rhizobium leguminosarum WSM2304

Rleg2_3065 - Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0003562 probable two-component sensor histidine kinase protein [a.k.a. ACI56332.1, integral membrane sensor hybrid histidine kinase, InterPro:IPR001789]

Alkalilimnicola ehrlichii

Mlg_1642 - Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: neu:NE1314 probable two-component sensor [a.k.a. ABI56988.1, InterPro:IPR003661, 114227189]

Chelativorans sp. BNC1

Meso_2145 - Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr2667 probable two-component sensor [a.k.a. ABG63537.1, 110285478, mes:Meso_2145]

Haloterrigena turkmenica

Htur_0546 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; KEGG: rec:RHECIAT_CH0000700 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ADB59444.1, ADB59444, IPR005467]

Nitrosomonas eutropha

Neut_1250 - Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: neu:NE1314 probable two-component sensor [a.k.a. ABI59503.1, InterPro:IPR003661, IPR005467]

Escherichia coli CFT073

c5041 - Putative transport sensor protein; Residues 20 to 591 of 606 are 31.81 pct identical to residues 28 to 612 of 633 from GenPept.129 : >gb|AAG04725.1|AE004563_2 (AE004563) probable two-component sensor [Pseudomonas aeruginosa] [a.k.a. AAN83467.1, GI:26111284, WP_000704419.1]

Paracoccus denitrificans

Pden_3312 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: ret:RHE_PF00324 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ABL71388.1, A1B794_PARDP, InterPro:IPR003661]

Paracoccus denitrificans

Pden_4741 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: ret:RHE_PF00324 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ABL72802.1, WP_011750961.1, pde:Pden_4741]

Acidovorax citrulli

Aave_1494 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS05645 probable two-component sensor histidine kinase transcription regulator protein [a.k.a. ABM32084.1, InterPro:IPR003661, A1TM96]

Acidovorax citrulli

Aave_3001 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS03102 probable two-component sensor kinase transcription regulator protein [a.k.a. ABM33568.1, A1TRI0_ACIAC, InterPro:IPR003661]

Burkholderia phymatum

Bphy_3928 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS05645 probable two-component sensor histidine kinase transcription regulator protein [a.k.a. ACC73054.1, InterPro:IPR003661, IPR005467]

Pseudogulbenkiania ferrooxidans

EEG06824.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS05645 probable two-component sensor histidine kinase transcription regulator protein [a.k.a. FuraDRAFT_3728, EEG06824, InterPro:IPR003661]

Ralstonia pickettii 12J

Rpic_3625 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RSc3403 probable two-component sensor kinase transcription regulator protein [a.k.a. ACD28744.1, GI:187727579, InterPro:IPR003661]

Ralstonia pickettii 12J

Rpic_4210 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS05645 probable two-component sensor histidine kinase transcription regulator protein [a.k.a. ACD29307.1, 6285645, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_3963 - PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: PAS domain containing protein; KEGG: rec:RHECIAT_CH0000031 probable two-component sensor histidine kinase protein [a.k.a. ACI57225.1, IPR001680, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_0703 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_CH01042 probable two-component sensor histidine kinase protein [a.k.a. ACI53999.1, ACI53999, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_1764 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_CH02129 probable two-component sensor histidine kinase protein [a.k.a. ACI55051.1, InterPro:IPR003661, IPR005467]

Rhizobium leguminosarum WSM2304

Rleg2_2050 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0002511 probable two-component sensor histidine kinase protein [a.k.a. ACI55334.1, B5ZS93_RHILW, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_2216 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_CH02576 probable two-component sensor histidine kinase protein [a.k.a. ACI55496.1, InterPro:IPR003661, IPR005467]

Rhizobium leguminosarum WSM2304

Rleg2_2747 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_CH03009 probable two-component sensor histidine kinase protein [a.k.a. ACI56018.1, rlt:Rleg2_2747, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_4372 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PC00058 probable two-component sensor histidine kinase protein [a.k.a. ACI57630.1, InterPro:IPR003661, 209537696]

Rhizobium leguminosarum WSM2304

Rleg2_4528 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; Cache type 2 domain protein; KEGG: ret:RHE_PC00157 probable two-component sensor histidine kinase protein [a.k.a. ACI57784.1, 34189814, 209537850]

Stenotrophomonas maltophilia R5513

Smal_0472 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: cvi:CV_0760 probable two-component sensor protein [a.k.a. ACF50177.1, ACF50177, InterPro:IPR003661]

Stenotrophomonas maltophilia R5513

Smal_2060 - Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: pae:PA3271 probable two-component sensor [a.k.a. ACF51764.1, InterPro:IPR013656, IPR001734]

Burkholderia pseudomallei K96243

BPSS0631 - Sensor protein; No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Escherichia coli sensor protein CpxA or EcfB or Ssd or Eup SWALL:CPXA_ECOLI (SWALL:P08336) (457 aa) fasta scores: E(): 9.9e-15, 31.93% id in 238 aa, and to Pseudomonas aeruginosa probable two-component sensor pa1798 SWALL:Q9I2U4 (EMBL:AE004606) (428 aa) fasta scores: E(): 1.7e-33, 39.17% id in 291 aa. Possible alternative translational start site [a.k.a. CAH38088.1, bps:BPSS0631, 52212081]

Magnetococcus marinus

Mmc1_3601 - Alginate biosynthesis sensor protein KinB; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: pae:PA5484 probable two-component sensor [a.k.a. ABK46086.1, A0LDP3_MAGMM, GI:117610631]

Marinomonas sp. MWYL1

ABR69934.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: atc:AGR_C_174 probable two-component sensor [a.k.a. Mmwyl1_1003, A6VU05_MARMS, InterPro:IPR003661]

Rhizobium leguminosarum WSM2304

Rleg2_0224 - Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: rec:RHECIAT_CH0000639 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ACI53524.1, 209533589, InterPro:IPR013656]

Campylobacter jejuni NCTC11168

racS - Original (2000) note: Cj1262, racS, probable two-component sensor (histidine kinase), len: 411 aa; 99.5% identical to TR:O68796 (EMBL:AF053961) C. jejuni putative histidine protein kinase (fragment) (189 aa), and similar to e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fast scores; opt: 188 z-score: 217.1 E(): 8.5e-05, 24.4% identity in 242 aa overlap. N-term has 28.2% identity to HP0165, C-term has 37.9% identity to HP0164. Also similar to Cj1226c (31.3% identity in 412 aa overlap). Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and Pfam match [...] [a.k.a. Cj1262, CAL35377.1, WP_002857920.1]

Marivirga tractuosa

Ftrac_1191 - Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR011622: IPR011623: IPR010822; KEGG: chu:CHU_1988 sensor protein for response regulator AtoC; PFAM: Diverse 7TM receptor transmembrane region; Diverse 7TM receptor extracellular region 2; Stage II sporulation protein E; SMART: protein phosphatase 2C domain protein; SPTR: Probable two-component sensor, putative; PFAM: 7TM diverse intracellular signalling; 7TMR-DISM extracellular 2; Stage II sporulation protein E (SpoIIE) [a.k.a. ADR21186.1, ADR21186, protein serine/threonine phosphatase]

Actinomyces odontolyticus

EDN81447.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: cgb:cg0331 2.6e-53 cgtS1; probable two-component sensor histidine kinase; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score:9.49 [a.k.a. ACTODO_01924, EDN81447, WP_003793069.1]

Actinomyces sp. F0337

EFW28330.1 - Histidine kinase; KEGG: bbe:BBR47_07780 5.5e-12 probable two-component sensor histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00 [a.k.a. HMPREF9057_00288, E7N688, WP_009393494.1]

Agrobacterium sp. H133

ADY66052.1 - Probable two-component sensor histidine kinase protein; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transduction histidine kinase [a.k.a. AGROH133_10020, F0LEP8_AGRSH, agr:AGROH133_10020]

Alistipes putredinis

EDS04590.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pae:PA3946 9.2e-34 probable two-component sensor K07679; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score: 7.88 [a.k.a. ALIPUT_00461, InterPro:IPR001789, EDS04590]

Alkalilimnicola ehrlichii

Mlg_0988 - CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region, ATPase domain protein domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein; KEGG: pae:PA1458 probable two-component sensor [a.k.a. ABI56341.1, ABI56341, IPR008208]

Anaerostipes caccae

EDR98677.1 - Phage tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 6.0e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5412 Phage-related protein; Psort location: CytoplasmicMembrane, score: 9.26 [a.k.a. ANACAC_00728, InterPro:IPR010090, phage tail tape measure protein, TP901 family]

Anaerotruncus colihominis

EDS11548.1 - Methyl-accepting chemotaxis protein signaling domain protein; KEGG: ret:RHE_PF00265 1.7e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: CytoplasmicMembrane, score: 9.49 [a.k.a. ANACOL_01754, B0PAF7_9FIRM, IPR004089]

Bacillus cellulosilyticus

Bcell_3738 - Signal transduction histidine kinase regulating citrate/malate metabolism; KEGG: bbe:BBR47_17240 probable two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein [a.k.a. ADU31978.1, ADU31978, bco:Bcell_3738]

Bacteroides caccae

EDM21902.1 - Transporter, MotA/TolQ/ExbB proton channel family protein; KEGG: ret:RHE_CH01297 0.21 probable two-component sensor histidine kinase protein; COG: COG0811 Biopolymer transport proteins; Psort location: CytoplasmicMembrane, score: 10.00 [a.k.a. BACCAC_00268, IPR002898, EDM21902]

Bacteroides caccae

EDM21948.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: ret:RHE_CH03146 6.2e-43 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score: 7.88 [a.k.a. BACCAC_00316, InterPro:IPR003661, InterPro:IPR009082]

Bacteroides caccae

EDM20727.1 - Transporter, SSS family; KEGG: ret:RHE_CH00566 8.9e-06 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. BACCAC_02190, Transporter, SSS family, IPR001734]

Bacteroides coprophilus

EEF78113.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pae:PA3946 1.5e-33 probable two-component sensor K07679; Psort location: CytoplasmicMembrane, score: 7.88 [a.k.a. BACCOPRO_03638, InterPro:IPR001789, S0FCE1]

Bacteroides eggerthii

EEC53507.1 - Uncharacterized protein; KEGG: ret:RHE_CH03146 1.8e-56 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 7.88 [a.k.a. BACEGG_02427, B7AJ37_BACEV, InterPro:IPR001789]

Bacteroides intestinalis

EDV04485.1 - Histidine kinase A domain protein; KEGG: ret:RHE_CH02441 2.0e-19 probable two-component sensor histidine kinase protein K07716; COG: COG0642 Signal transduction histidine kinase [a.k.a. BACINT_03621, InterPro:IPR003661, InterPro:IPR009082]

Bacteroides ovatus

panF - Transporter, SSS family; KEGG: ret:RHE_CH00566 8.4e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. BACOVA_01257, EDO13017.1, Transporter, SSS family]

Bacteroides pectinophilus

EEC56834.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 3.3e-11 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. BACPEC_01318, GI:217990828, InterPro:IPR010090]

Bacteroides plebeius

EDY96172.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pae:PA3946 9.2e-34 probable two-component sensor K07679; Psort location: CytoplasmicMembrane, score: 7.88 [a.k.a. BACPLE_01480, 198271902, InterPro:IPR001789]

Bacteroides stercoris

EDS15608.1 - PAS domain S-box protein; KEGG: ret:RHE_CH03146 2.0e-57 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0642 Signal transduction histidine kinase [a.k.a. BACSTE_01047, InterPro:IPR001789, InterPro:IPR003661]

Bdellovibrio bacteriovorus HD100

Bd2576 - Probable TWO-component sensor histidine kinase transcription regulatorprotein; hypothetical protein [a.k.a. CAE80372.1, UniProtKB/TrEMBL:Q6MK37, InterPro:IPR003661]

Bifidobacterium catenulatum

EEB22271.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 2.5e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: Cellwall, score: 9.17 [a.k.a. BIFCAT_00285, bcat:BBCT_1510, 212661696]

Blastopirellula marina

EAQ78262.1 - Probable two-component sensor histidine kinase FixL; COG0642 Signal transduction histidine kinase [a.k.a. DSM3645_18036, GI:87286354, A3ZYQ1_9PLAN]

Blautia hydrogenotrophica

EEG49669.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 7.1e-05 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. RUMHYD_01482, IPR001680, InterPro:IPR010090]

Blautia hydrogenotrophica

EEG49162.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 1.6e-05 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. RUMHYD_01973, InterPro:IPR001579, Hypothetical protein]

Bordetella bronchiseptica

BB0018 - Probable two-component sensor protein; Ortholog of Bordetella pertussis (BX470248) BP0019 [a.k.a. NP_886571.1, WP_010925685.1, bbr:BB0018]

Bordetella bronchiseptica

BB2739 - Probable two-component sensor histidine kinase; Ortholog of Bordetella pertussis (BX470248) BP1658 [a.k.a. NP_889275.1, 33601715, bbr:BB2739]

Bordetella pertussis Tohama

BP1658 - Probable two-component sensor histidine kinase; The C-terminal region of this CDS is [a.k.a. NP_880382.1, Q7VXS9, GI:33592738]

Brevundimonas diminuta 4704

EKY29859.1 - Response regulator receiver domain protein; KEGG: rec:RHECIAT_CH0002627 2.5e-77 probable two-component sensor histidine kinase protein; Psort location: Cytoplasmic, score: 8.96 [a.k.a. HMPREF0185_01003, 429189001, WP_004370807.1]

Burkholderia pseudomallei K96243

BPSS1646 - Similar to Pseudomonas aeruginosa probable two-component sensor pa2571 SWALL:Q9I0R5 (EMBL:AE004685) (470 aa) fasta scores: E(): 1.4e-47, 46.91% id in 373 aa, and to Xanthomonas campestris histidine kinase xcc1957 SWALL:AAM41246 (EMBL:AE012299) (408 aa) fasta scores: E(): 2.1e-47, 50.95% id in 314 aa [a.k.a. CAH39120.1, probable two-component sensor kinase, UniProtKB/TrEMBL:Q63JS0]

Chloroflexus aurantiacus

Caur_1208 - PFAM: GAF domain protein; ATP-binding region ATPase domain protein; KEGG: pae:PA1979 probable two-component sensor [a.k.a. ABY34437.1, IPR003018, A9WJY6_CHLAA]

Chromobacterium violaceum

CV_0594 - Probable two-component sensor histidine kinase protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642 [a.k.a. AAQ58270.1, Q7P0H3_CHRVO, 2.7.13.3]

Chromobacterium violaceum

CV_0760 - Probable two-component sensor protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642 [a.k.a. AAQ58436.1, probable two-component sensor protein, 24946811]

Chromobacterium violaceum

CV_3106 - Probable two-component sensor histidine kinase; Identified by sequence similarity; putative; ORF located using Blastx/COG0642 [a.k.a. AAQ60774.1, cvi:CV_3106, Probable two-component sensor histidine kinase]

Chromobacterium violaceum

CV_3844 - Probable two-component sensor protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642 [a.k.a. AAQ61506.1, GI:34105150, probable two-component sensor protein]

Chthoniobacter flavus

EDY20755.1 - Histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. CfE428DRAFT_1952, InterPro:IPR001789, IPR003018]

Clostridium bolteae

EDP18994.1 - Uncharacterized protein; KEGG: ret:RHE_CH00566 8.2e-10 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. CLOBOL_00430, IPR001734, GI:158441284]

Clostridium bolteae

EDP14400.1 - Uncharacterized protein; KEGG: ret:RHE_CH00566 4.2e-10 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. CLOBOL_04942, IPR001734, A8RXT3]

Clostridium hylemonae

panF - Sodium/pantothenate symporter; KEGG: ret:RHE_CH00566 5.4e-07 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. CLOHYLEM_05908, EEG73903.1, IPR001734]

Clostridium leptum

EDO59646.1 - Transporter, SSS family; KEGG: ret:RHE_CH00566 1.4e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. CLOLEP_03696, Transporter, SSS family, IPR001734]

Clostridium scindens

EDS06189.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: ret:RHE_CH02326 3.0e-25 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score: 9.49 [a.k.a. CLOSCI_02760, B0NH05, InterPro:IPR003661]

Clostridium sp. L250

EDO57631.1 - Tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 0.00053 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5280 Phage-related minor tail protein [a.k.a. CLOL250_01721, Tail tape measure protein, TP901 family, tail tape measure protein, TP901 family]

Collinsella stercoris

EEA91670.1 - YhgE/Pip domain protein; KEGG: ret:RHE_PF00265 2.8e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 10.00 [a.k.a. COLSTE_00125, WP_006719600.1, B6G7T5]

Collinsella stercoris

EEA91671.1 - YhgE/Pip domain protein; KEGG: ret:RHE_PF00265 0.00093 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 9.99 [a.k.a. COLSTE_00126, WP_006719601.1, GI:210160700]

Desulfatibacillum alkenivorans

Dalk_1390 - KEGG: rec:RHECIAT_PC0000457 probable two-component sensor histidine kinase/response regulator hybrid protein; IMG reference gene:2503007095 [a.k.a. ACL03090.1, WP_012610525.1, ACL03090]

Dorea formicigenerans ATCC27755

EDR48078.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 7.2e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5412 Phage-related protein; Psort location: CytoplasmicMembrane, score: 9.99 [a.k.a. DORFOR_00735, WP_005331402.1, EDR48078]

Eikenella corrodens ATCC23834

fimV - FimV domain protein; KEGG: pae:PA1458 7.0e-17 probable two-component sensor K03407; Psort location: Periplasmic, score: 9.83 [a.k.a. EIKCOROL_02110, EEG23180.1, ecor:SAMEA4412678_1538]

Eubacterium ventriosum

EDM52240.1 - Phage tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 1.4e-07 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5412 Phage-related protein; Psort location: CytoplasmicMembrane, score: 9.99 [a.k.a. EUBVEN_00436, InterPro:IPR010978, InterPro:IPR010090]

Fluviicola taffensis

Fluta_0711 - Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932:IPR011623:IPR010822; KEGG: lbf:LBF_1008 serine phosphatase RsbU; PFAM: 7TM-DISM receptor, extracellular domain, type 1; Sporulation stage II, protein E C-terminal; SMART: Protein phosphatase 2C-related; SPTR: Probable two-component sensor, putative; PFAM: 7TM diverse intracellular signalling; 7TMR-DISM extracellular 2; Stage II sporulation protein E (SpoIIE) [a.k.a. AEA42715.1, protein serine/threonine phosphatase, F2II15_FLUTR]

Fulvimarina pelagi

EAU40284.1 - Probable two-component sensor histidine kinase protein; COG0642 Signal transduction histidine kinase [a.k.a. FP2506_03620, EAU40284, Q0FZJ4]

Glaciecola sp. 4H37YE5

Glaag_2578 - CheA signal transduction histidine kinase; KEGG: amc:MADE_00412 probable two-component sensor (CheA); PFAM: ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; CheW domain protein; SMART: CheW domain protein; Hpt domain protein; ATP-binding region ATPase domain protein [a.k.a. AEE23519.1, 0004871, InterPro:IPR004105]

Holdemania filiformis

EEF69305.1 - PAS domain S-box protein; KEGG: ret:RHE_PF00222 5.0e-08 probable two-component sensor histidine kinase protein; Psort location: Cytoplasmic, score: 8.87 [a.k.a. HOLDEFILI_00519, InterPro:IPR013655, IPR001610]

Hyphomicrobium denitrificans ATCC51888

Hden_1140 - Histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0001392 probable two-component sensor histidine kinase protein; PFAM: histidine kinase A domain protein; SMART: histidine kinase A domain protein [a.k.a. ADJ22954.1, InterPro:IPR003661, 299524485]

Kyrpidia tusciae

Btus_0034 - Signal transduction histidine kinase, nitrogen specific, NtrB; KEGG: bbe:BBR47_00630 probable two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein [a.k.a. ADG04812.1, InterPro:IPR003661, D5WRF1]

Kyrpidia tusciae

Btus_2041 - Histidine kinase; KEGG: bbe:BBR47_46530 probable two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein [a.k.a. ADG06731.1, ADG06731, InterPro:IPR003661]

Labrenzia aggregata

EAV41916.1 - Probable two-component sensor histidine kinase protein; COG0642 Signal transduction histidine kinase [a.k.a. SIAM614_24892, lagg:B0E33_14660, AQQ04662]

Labrenzia aggregata

EAV42497.1 - Probable two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [a.k.a. SIAM614_28057, WP_006936993.1, A0NXH0_LABAI]

Labrenzia aggregata

EAV41519.1 - Probable two-component sensor histidine kinase protein; COG4585 Signal transduction histidine kinase [a.k.a. SIAM614_30451, AQQ08085, GI:118434869]

Leptothrix cholodnii

Lcho_1633 - Putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: bbr:BB2739 probable two-component sensor histidine kinase [a.k.a. ACB33900.1, 170775761, GI:170775761]

Loktanella vestfoldensis SKA53

phoR - Probable two-component sensor histidine kinase; COG0642 Signal transduction histidine kinase [a.k.a. SKA53_04763, EAQ06370.1, 14132]

Marivirga tractuosa

Ftrac_1348 - Histidine kinase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR005467: IPR003594; KEGG: cpi:Cpin_6820 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Probable two-component sensor; manually curated; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [a.k.a. ADR21338.1, E4TM62_MARTH, WP_013453487.1]

Methylobacterium extorquens PA1

Mext_1926 - PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mlo:mlr1132 probable two-component sensor [a.k.a. ABY30325.1, ABY30325, InterPro:IPR001789]

Methylobacterium sp. 446

M446_5171 - Histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ACA19496.1, InterPro:IPR001789, IPR003018]

Mycobacterium tuberculosis H37Rv

Rv2680 - Conserved protein; Rv2680, (MTV010.04), len: 210 aa. Conserved protein,equivalent to Q50005|ML1041|U1764V hypothetical protein from Mycobacterium leprae (196 aa), FASTA scores: opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa overlap). Also similar to O69860|SC1C3.18c hypothetical 24.7 KDA protein from Streptomyces coelicolor (238 aa), FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in 189 aa overlap); and similar in part to Q9I6V4|PA0178 probable two-component sensor from Pseudomonas aeruginosa (639 aa),FASTA scores: opt: 120, E(): 3.1, (33.05% identity in 115 aa overlap); an [...] [a.k.a. CCP45478.1, mtu:Rv2680, GI:444896217]

Nostoc punctiforme

Npun_R1110 - Histidine kinase; PFAM: ATP-binding region, ATPase domain protein; KEGG: gvi:gll4098 probable two-component sensor histidine kinase [a.k.a. ACC79836.1, B2IW91, GI:186464035]

Oceanibulbus indolifex

EDQ05754.1 - Probable two-component sensor histidine kinase protein; COG0642 Signal transduction histidine kinase [a.k.a. OIHEL45_03050, A9DSZ5_9RHOB, 161381345]

Parabacteroides merdae

EDN86451.1 - Transporter, SSS family; KEGG: ret:RHE_CH00566 0.0017 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. PARMER_01813, Transporter, SSS family, IPR001734]

Paracoccus denitrificans

Pden_4406 - Histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: ret:RHE_CH03434 probable two-component sensor histidine kinase protein [a.k.a. ABL72470.1, ABL72470, InterPro:IPR003661]

Parvibaculum lavamentivorans

Plav_2355 - TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein; KEGG: ret:RHE_PF00222 probable two-component sensor histidine kinase protein [a.k.a. ABS63967.1, InterPro:IPR013656, A7HVN4_PARL1]

Planctomyces brasiliensis

Plabr_2647 - COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660: IPR003661: IPR003594; KEGG: plm:Plim_2085 ATP-binding region ATPase domain protein; PFAM: ATPase-like, ATP-binding domain; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: Probable two-component sensor histidine kinase FixL; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kina [...] [a.k.a. ADY60247.1, pbs:Plabr_2647, 324969469]

Planctomyces maris

EDL56090.1 - Probable two-component sensor histidine kinase FixL; COG0642 Signal transduction histidine kinase [a.k.a. PM8797T_01349, 148841676, GI:148841676]

Pseudoalteromonas tunicata

PTD2_06115 - Probable two-component sensor kinase transcription regulator protein; COG0642 Signal transduction histidine kinase [a.k.a. EAR27223.1, 88817405, A4CE31_9GAMM]

Pseudoflavonifractor capillosus

EDM98255.1 - Uncharacterized protein; KEGG: ret:RHE_PF00265 7.7e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG4886 Leucine-rich repeat (LRR) protein [a.k.a. BACCAP_03913, GI:150270981, IPR011493]

Pseudoflavonifractor capillosus

EDM98125.1 - Transporter, SSS family; KEGG: ret:RHE_CH00566 8.6e-17 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG4145 Na+/panthothenate symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. BACCAP_04004, Transporter, SSS family, IPR001734]

Pseudogulbenkiania ferrooxidans

EEG07636.1 - Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: cvi:CV_3445 probable two-component sensor [a.k.a. FuraDRAFT_2958, InterPro:IPR003661, IPR005467]

Ralstonia solanacearum GMI1000

kdpD - Probable two-component sensor kinase kdpd transcription regulator protein; Cell processes; transport of small molecules [a.k.a. RSc3385, CAD16882.1, 1222249]

Ralstonia solanacearum GMI1000

RSc3403 - Probable two-component sensor kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD16900.1, GOA:Q8XTZ2, InterPro:IPR003661]

Ralstonia solanacearum GMI1000

RSp1043 - Probable two-component sensor histidine kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD18194.1, InterPro:IPR003661, Q8XR25]

Ralstonia solanacearum GMI1000

RSp1162 - Probable two-component sensor histidine kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD18313.1, InterPro:IPR003661, InterPro:IPR009082]

Ralstonia solanacearum GMI1000

RSp1441 - Probable two-component sensor kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD18592.1, InterPro:IPR003661, InterPro:IPR009082]

Rhizobium etli CFN42

ABC89254.1 - Probable two-component sensor histidine kinase protein; Similar to mlr9681 [Mesorhizobium loti]; Similar to swissprot:Q98NY7; Putative location:bacterial cytoplasm Psort-Score: 0.2667; Protein involved in ATP binding, kinase activity, signal transducer activity and signal transduction [a.k.a. RHE_CH00432, PF02518.9, ret:RHE_CH00432]

Rhizobium etli CFN42

ABC90530.1 - Probable two-component sensor histidine kinase protein; Similar to SMb21519 [Sinorhizobium meliloti]; Similar to swissprot:Q92TZ4; Putative location:bacterial inner membrane Psort-Score: 0.4673; Protein involved in ATP binding, kinase activity, transferase activity and signal transduction [a.k.a. RHE_CH01735, PF02518.9, Q2K9F6]

Rhizobium etli CFN42

mctS - Probable two-component sensor histidine kinase protein; Similar to entrez-protein:CAD19126.1; Putative location:bacterial inner membrane Psort-Score: 0.5713; Similar to mctS [Rhizobium leguminosarum bv. viciae], BMEI1583 [Brucella melitensis] and AGR_pAT_381p[Agrobacterium tumefaciens]; Protein involved in ATP binding, kinase activity and signal transduction [a.k.a. RHE_PC00157, ABC93363.1, PF02518.9]

Rhizobium etli CIAT652

ACE89034.1 - Probable two-component sensor histidine kinase protein; Ypch00012; Protein involved in ATP binding [a.k.a. RHECIAT_CH0000031, B3PVW1_RHIE6, WP_012482106.1]

Rhizobium etli CIAT652

ACE89467.1 - Probable two-component sensor histidine kinase protein; Ypch00181 [a.k.a. RHECIAT_CH0000473, WP_012482458.1, rec:RHECIAT_CH0000473]

Rhizobium etli CIAT652

ACE89630.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Ypch00228; Protein involved in ATP binding [a.k.a. RHECIAT_CH0000639, ACE89630, WP_012482600.1]

Rhizobium etli CIAT652

ACE89689.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Ypch00252; Protein involved in ATP binding [a.k.a. RHECIAT_CH0000700, IPR003594, B3PPI2_RHIE6]

Rhizobium etli CIAT652

ACE89691.1 - Probable two-component sensor histidine kinase protein; Ypch00254; Protein involved in ATP binding [a.k.a. RHECIAT_CH0000702, B3PPI4_RHIE6, B3PPI4]

Rhizobium etli CIAT652

ACE89793.1 - Probable two-component sensor histidine kinase protein; Ypch00269; Protein involved in ATP binding [a.k.a. RHECIAT_CH0000804, B3PQE7_RHIE6, WP_012482730.1]

Rhizobium etli CIAT652

ACE90329.1 - Probable two-component sensor histidine kinase protein; Ypch00458; Protein involved in ATP binding [a.k.a. RHECIAT_CH0001348, GI:190696244, ACE90329]

Rhizobium etli CIAT652

ACE90372.1 - Probable two-component sensor histidine kinase protein; Ypch00470; Protein involved in ATP binding [a.k.a. RHECIAT_CH0001392, GI:190696287, B3PU68_RHIE6]

Rhizobium etli CIAT652

ACE90783.1 - Probable two-component sensor histidine kinase protein; Ypch00610; Protein involved in ATP binding [a.k.a. RHECIAT_CH0001813, B3PWY5, rec:RHECIAT_CH0001813]

Rhizobium etli CIAT652

ACE91139.1 - Probable two-component sensor histidine kinase protein; Ypch00711; Protein involved in ATP binding [a.k.a. RHECIAT_CH0002181, B3Q0D5, IPR003594]

Rhizobium etli CIAT652

ACE91463.1 - Probable two-component sensor histidine kinase protein; Ypch00837; Protein involved in ATP binding [a.k.a. RHECIAT_CH0002511, GI:190697378, WP_012484085.1]

Rhizobium etli CIAT652

ACE91494.1 - Probable two-component sensor histidine kinase protein; Ypch00856; Protein involved in ATP binding [a.k.a. RHECIAT_CH0002542, IPR003594, WP_012484110.1]

Rhizobium etli CIAT652

ACE91579.1 - Probable two-component sensor histidine kinase protein; Ypch00889 [a.k.a. RHECIAT_CH0002627, B3PRL9, WP_012484179.1]

Rhizobium etli CIAT652

ACE92114.1 - Probable two-component sensor histidine kinase protein; Ypch01098; Protein involved in ATP binding [a.k.a. RHECIAT_CH0003166, rec:RHECIAT_CH0003166, IPR003594]

Rhizobium etli CIAT652

ACE92316.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Ypch01158; Protein involved in ATP binding [a.k.a. RHECIAT_CH0003368, B3PW79, 190698231]

Rhizobium etli CIAT652

ACE92508.1 - Probable two-component sensor histidine kinase protein; Ypch01238; Protein involved in ATP binding [a.k.a. RHECIAT_CH0003562, ACE92508, 190698423]

Rhizobium etli CIAT652

ACE92609.1 - Probable two-component sensor histidine kinase protein; Ypch01277; Protein involved in ATP binding [a.k.a. RHECIAT_CH0003670, 190698524, B3PY88_RHIE6]

Rhizobium etli CIAT652

ACE92792.1 - Probable two-component sensor histidine kinase protein; Ypch01337 [a.k.a. RHECIAT_CH0003855, IPR013727, WP_012485220.1]

Rhizobium etli CIAT652

ACE94489.1 - Probable two-component sensor histidine kinase protein; Ypc00254 [a.k.a. RHECIAT_PC0000411, InterPro:IPR007895, rec:RHECIAT_PC0000411]

Rhizobium etli CIAT652

ACE94535.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Ypc00273; Protein involved in ATP binding [a.k.a. RHECIAT_PC0000457, GI:190700453, B3Q5Q4_RHIE6]

Rhizobium etli CIAT652

ACE94588.1 - Probable two-component sensor histidine kinase protein; Ypc00310; Protein involved in ATP binding [a.k.a. RHECIAT_PC0000510, rec:RHECIAT_PC0000510, 190700506]

Rhizobium etli CIAT652

ACE94600.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; Ypc00318; Protein involved in ATP binding [a.k.a. RHECIAT_PC0000522, 190700518, rec:RHECIAT_PC0000522]

Rhizobium leguminosarum WSM2304

Rleg2_0075 - PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation/phosphoacceptor; KEGG: rec:RHECIAT_CH0000473 probable two-component sensor histidine kinase protein [a.k.a. ACI53378.1, WP_012556420.1, ACI53378]

Rhizobium leguminosarum WSM2304

Rleg2_0283 - PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rec:RHECIAT_CH0000700 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ACI53582.1, GI:209533647, InterPro:IPR001789]

Rhizobium leguminosarum WSM2304

Rleg2_1390 - Putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: rec:RHECIAT_CH0001813 probable two-component sensor histidine kinase protein [a.k.a. ACI54684.1, B5ZZ91_RHILW, putative signal transduction histidine kinase]

Rhizobium leguminosarum WSM2304

Rleg2_2165 - Signal transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase dimerisation/phosphoacceptor; KEGG: rec:RHECIAT_CH0002627 probable two-component sensor histidine kinase protein [a.k.a. ACI55448.1, InterPro:IPR001789, rlt:Rleg2_2165]

Rhizobium leguminosarum WSM2304

Rleg2_3170 - Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: ret:RHE_CH03434 probable two-component sensor histidine kinase protein [a.k.a. ACI56437.1, InterPro:IPR003661, B5ZNI9_RHILW]

Rhizobium leguminosarum WSM2304

Rleg2_5393 - Histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ACI58573.1, InterPro:IPR001789, IPR003018]

Rhizobium leguminosarum WSM2304

Rleg2_5394 - PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00264 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ACI58574.1, InterPro:IPR001789, InterPro:IPR003661]

Rhodobacterales bacterium HTCC2255

EAU53097.1 - Probable two-component sensor histidine kinase; COG0642 Signal transduction histidine kinase [a.k.a. OM2255_06195, WP_008034494.1, 114550216]

Rhodopirellula baltica

RB12509 - Probable two-component sensor histidine kinase; PMID: 1528845 best DB hits: BLAST: pir:T30898; receptor-like histidine kinase - Rhodococcus erythropolis; E=6e-08 pir:T28694; hypothetical protein - Streptomyces coelicolor -----; E=1e-07 pir:T28655; receptor-like histidine kinase BpdS - Rhodococcus sp; E=2e-07 COG: narQ; COG0642 Sensory transduction histidine kinases; E=2e-08 PFAM: PF02518; Histidine kinase-, DNA gyrase B-, p; E=1.9e-05 [a.k.a. NP_870552.1, 32477558, NP_870552]

Rhodopirellula baltica

RB12949 - Histidine protein kinase; PMID: 8757734 best DB hits: BLAST: gb:AAB38420.1; (L39938) histidine protein kinase [Sinorhizobium; E=2e-16 pir:E83083; probable two-component sensor PA4494 [imported] -; E=3e-16 gb:AAA93222.1; (U22925) RegB [Rhodobacter sphaeroides]; E=2e-12 COG: PA4494; COG0642 Sensory transduction histidine kinases; E=2e-17 PFAM: PF00512; His Kinase A (phosphoacceptor; E=0.011 PF02518; Histidine kinase-, DNA gyrase; E=1.2e-28 [a.k.a. NP_870789.1, 32477795, NP_870789]

Roseobacter sp. CCS2

EBA10954.1 - Probable two-component sensor histidine kinase; COG0642 Signal transduction histidine kinase [a.k.a. RCCS2_00694, GI:126714085, A4EM67_9RHOB]

Roseovarius sp. TM1035

EDM31248.1 - Probable two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [a.k.a. RTM1035_02125, 149143209, A6E267]

Ruminococcus gnavus

EDN75767.1 - Phage tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 1.9e-10 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5280 Phage-related minor tail protein; Psort location: Cellwall, score:9.17 [a.k.a. RUMGNA_03897, GI:153793344, InterPro:IPR010090]

Ruminococcus lactaris

EDY32665.1 - Putative sodium/proline symporter; KEGG: ret:RHE_CH00566 1.3e-08 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. RUMLAC_01609, IPR001734, GI:197298117]

Ruminococcus lactaris

EDY32086.1 - Phage tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 1.0e-06 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5280 Phage-related minor tail protein; Psort location: CytoplasmicMembrane, score: 9.99 [a.k.a. RUMLAC_02249, InterPro:IPR010978, InterPro:IPR010090]

Ruminococcus obeum ATCC29174

EDM87544.1 - Phage tail tape measure protein, TP901 family; KEGG: ret:RHE_PF00265 2.1e-06 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG5412 Phage-related protein [a.k.a. RUMOBE_01725, 149832460, InterPro:IPR010090]

Ruminococcus torques ATCC27756

EDK23209.1 - KEGG: ret:RHE_CH00566 4.4e-08 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score: 10.00 [a.k.a. RUMTOR_02582, IPR001734, 145846291]

Saccharopolyspora erythraea

SACE_0998 - Probable two-component sensor kinase; Signal transduction histidine kinase [a.k.a. A8924_1391, CAM00330.1, CAM00330]

Sagittula stellata

EBA06973.1 - Probable two-component sensor histidine kinase protein; COG4585 Signal transduction histidine kinase [a.k.a. SSE37_00840, WP_005861719.1, EBA06973]

Sagittula stellata

EBA06798.1 - Probable two-component sensor histidine kinase protein; COG0642 Signal transduction histidine kinase [a.k.a. SSE37_02885, A3K826_9RHOB, GI:126707736]

Sagittula stellata

EBA05685.1 - Probable two-component sensor kinase transcription regulator protein; COG0642 Signal transduction histidine kinase [a.k.a. SSE37_03265, EBA05685, GI:126706610]

Sagittula stellata

EBA10077.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; COG0642 Signal transduction histidine kinase [a.k.a. SSE37_18767, A3JX41_9RHOB, EBA10077]

Sagittula stellata

EBA09407.1 - Probable two-component sensor histidine kinase protein; COG0642 Signal transduction histidine kinase [a.k.a. SSE37_24234, A3K0U2_9RHOB, EBA09407]

Shewanella amazonensis

Sama_0155 - Signal transduction histidine kinase-like protein; KEGG: pae:PA1158 probable two-component sensor [a.k.a. ABL98367.1, A1S1W1, GI:119765797]

Sinorhizobium medicae

Smed_5321 - Putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: ret:RHE_PF00480 probable two-component sensor histidine kinase protein [a.k.a. ABR64094.1, 150031979, 5319623]

Slackia exigua

EEZ61923.1 - Putative sodium/proline symporter; KEGG: ret:RHE_CH00566 0.0036 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. HMPREF0762_00564, IPR001734, GI:269130847]

Solibacter usitatus

Acid_2046 - Histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein [a.k.a. ABJ83036.1, InterPro:IPR001789, IPR003018]

Sphingomonas sp. SKA58

EAT07139.1 - Probable two-component sensor histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain [a.k.a. SKA58_11483, EAT07139, GI:94422095]

Stenotrophomonas maltophilia K279a

Smlt3489 - Putative transmembrane GGDEF transcriptional regulatory protein; Similarity:fasta; BB0018; bbronchiseptica; probable two-component sensor protein; length 781 aa; id=36.6%; E()=2.2e-17; 383 aa overlap; query 2-367 aa; subject 3-369 aa [a.k.a. CAQ46912.1, IPR007890, WP_012480935.1]

Streptomyces coelicolor

SCO6668 - SC5A7.18c, probable two-component sensor, len: 405 aa; similar in C-terminus to many e.g. NARQ_ECOLI nitrate [a.k.a. SC5A7.18c, NP_630743.1, O88024_STRCO]

Subdoligranulum variabile

EFB75031.1 - Putative sodium/proline symporter; KEGG: ret:RHE_CH00566 3.3e-12 probable two-component sensor histidine kinase/response regulator hybrid protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. SUBVAR_06668, IPR001734, GI:282569496]

Wolinella succinogenes

WS0016 - PROBABLE TWO-COMPONENT SENSOR [a.k.a. NP_906290.1, Q7MAU6, GI:34556475]

Frankia sp. EAN1pec

ABW12793.1 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: sco:SCO7089 probable two-component system sensor kinase [a.k.a. Franean1_3391, 158110596, GI:158110596]

Burkholderia pseudomallei K96243

BPSL2302 - Sensor kinase protein; Weakly similar to Rhodobacter capsulatus C4-dicarboxylate transport sensor protein DctS SWALL:DCTS_RHOCA (SWALL:P37739) (657 aa) fasta scores: E(): 3.1e-26, 30.07% id in 788 aa. Similar to Ralstonia solanacearum probable two-component transmembrane sensor histidine kinase transcription regulator protein rsc1598 or rs03960 SWALL:Q8XZ08 (EMBL:AL646065) (857 aa) fasta scores: E(): 1e-180, 57.72% id in 790 aa [a.k.a. CAH36305.1, Q63SL8_BURPS, UniProtKB/TrEMBL:Q63SL8]

Burkholderia ambifaria

Bamb_5870 - PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; SMART: PAS domain containing protein; KEGG: bps:BPSS1605 probable two-component system sensor kinase [a.k.a. ABI91416.1, bam:Bamb_5870, Q0B357]

Burkholderia pseudomallei K96243

BPSS0706 - Similar to Escherichia coli sensor protein QseC SWALL:QSEC_ECOLI (SWALL:P40719) (449 aa) fasta scores: E(): 1.5e-29, 33.11% id in 468 aa, and to Ralstonia solanacearum probable two-component transmembrane sensor kinase transcription regulator protein rsc1735 or rs02923 SWALL:Q8XYM3 (EMBL:AL646066) (471 aa) fasta scores: E(): 2.4e-87, 59.64% id in 456 aa. CDS is extended at the C-terminus in comparison to orthologues [a.k.a. CAH38166.1, IPR013727, 52212149]

Burkholderia pseudomallei K96243

BPSL0807 - Similar to Escherichia coli sensor protein QseC SWALL:QSEC_ECOLI (SWALL:P40719) (449 aa) fasta scores: E(): 4.1e-30, 31.04% id in 451 aa, and to Ralstonia solanacearum probable transmembrane two-component sensor kinase transcription regulator protein rsp1553 or rs02109 SWALL:Q8XPT4 (EMBL:AL646085) (438 aa) fasta scores: E(): 3e-69, 50.22% id in 438 aa [a.k.a. CAH34799.1, 3092687, CAH34799]

Burkholderia pseudomallei K96243

BPSS0642 - Similar to Escherichia coli sensor protein QseC SWALL:QSEC_ECOLI (SWALL:P40719) (449 aa) fasta scores: E(): 4.6e-27, 32.08% id in 452 aa, and to Ralstonia solanacearum probable transmembrane two-component sensor kinase transcription regulator protein rsp1553 or rs02109 SWALL:Q8XPT4 (EMBL:AL646085) (438 aa) fasta scores: E(): 9.4e-50, 41.34% id in 445 aa [a.k.a. CAH38099.1, GI:52212090, InterPro:IPR003661]

Burkholderia ambifaria

Bamb_6238 - Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: rso:RSc1075 probable two-component system sensor histidine kinase transcription regulator protein [a.k.a. ABI91782.1, 115286307, InterPro:IPR003661]

Ralstonia pickettii 12J

Rpic_4862 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS02109 probable transmembrane two-component sensor kinase transcription regulator protein [a.k.a. ACD29946.1, InterPro:IPR003661, IPR005467]

Burkholderia ambifaria

Bamb_1427 - Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; CHASE2 domain protein; KEGG: rso:RSc1075 probable two-component system sensor histidine kinase transcription regulator protein [a.k.a. ABI86985.1, IPR007890, ABI86985]

Arthrobacter sp. FB24

Arth_0116 - Multi-sensor signal transduction histidine kinase; PFAM: GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sth:STH749 two-component sensor kinase, probably involved in phosphate sensing [a.k.a. ABK01517.1, ABK01517, IPR013516]

Solibacter usitatus

Acid_1851 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; CHASE2 domain protein; KEGG: sth:STH749 two-component sensor kinase, probably involved in phosphate sensing [a.k.a. ABJ82841.1, IPR007890, InterPro:IPR003661]

Ralstonia pickettii 12J

Rpic_0941 - Multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CHASE2 domain protein; PAS fold-4 domain protein; KEGG: rso:RSc1075 probable two-component system sensor histidine kinase transcription regulator protein [a.k.a. ACD26091.1, IPR007890, InterPro:IPR013656]

Polaromonas naphthalenivorans

Pnap_2971 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: rso:RS03089 probable two-component transmembrane sensor kinase transcription regulator protein [a.k.a. ABM38270.1, InterPro:IPR003661, IPR005467]

Anaerococcus hydrogenalis

panF - Sodium/pantothenate symporter; KEGG: azo:azo2412 5.6e-10 probable two-component system sensor protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. ANHYDRO_00934, EEB36282.1, IPR001734]

Anaerostipes caccae

EDR96849.1 - Uncharacterized protein; KEGG: cvi:CV1579 3.2e-09 probable two-component hybrid sensor and regulator; COG: COG1196 Chromosome segregation ATPases; Psort location: Cytoplasmic, score: 8.87 [a.k.a. ANACAC_02627, GI:167652720, IPR009053]

Bacteroides caccae

EDM19474.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: cvi:CV1579 6.5e-33 probable two-component hybrid sensor and regulator; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score: 9.82 [a.k.a. BACCAC_03223, GI:149128255, A5ZJY6]

Bacteroides plebeius

EDY96050.1 - Histidine kinase A domain protein; KEGG: spt:SPA3047 1.6e-21 ygiY; probable two-component system sensor histidine kinase K07645; Psort location: CytoplasmicMembrane, score: 9.82 [a.k.a. BACPLE_01356, InterPro:IPR003661, InterPro:IPR009082]

Bifidobacterium gallicum

BGLCM_0322 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: mle:ML2440 1.7e-47 probable two-component system sensor histidine kinase K07768; Psort location: CytoplasmicMembrane, score: 9.49 [a.k.a. BIFGAL_03733, EFA22702.1, D1NV51_9BIFI]

Chromobacterium violaceum

CV_0103 - Probable two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2972 [a.k.a. AAQ57782.1, cvi:CV_0103, Q7P1V9_CHRVO]

Chromobacterium violaceum

CV_0920 - Probable two-component transmembrane sensor; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0642 [a.k.a. AAQ58594.1, Probable two-component transmembrane sensor, Q7NZK2_CHRVO]

Chromobacterium violaceum

CV_1665 - Probable two-component system sensor kinase; Identified by sequence similarity; putative; ORF located using Glimmer/Blastx/COG3275 [a.k.a. AAQ59341.1, AAQ59341, probable two-component system sensor kinase]

Chromobacterium violaceum

CV_4218 - Probable two-component system sensor kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0642 [a.k.a. AAQ61878.1, probable two-component system sensor kinase, Q7NQC2_CHRVO]

Clostridium hylemonae

EEG72903.1 - ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: sth:STH749 1.7e-32 two-component sensor kinase, probably involved in phosphate sensing K02484; Psort location: CytoplasmicMembrane, score: 10.00 [a.k.a. CLOHYLEM_06925, IPR011623, InterPro:IPR003661]

Dialister invisus

EEW96686.1 - Uncharacterized protein; KEGG: cvi:CV1579 0.0025 probable two-component hybrid sensor and regulator [a.k.a. GCWU000321_00649, C9LMA0_9FIRM, C9LMA0]

Faecalibacterium prausnitzii A2165

EEU95813.1 - Putative sodium/proline symporter; KEGG: azo:azo2412 4.5e-09 probable two-component system sensor protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. FAEPRAA2165_02752, C7H8V8_9FIRM, IPR001734]

Lactobacillus oryzae

GAK47315.1 - Probable two-component transmembrane sensor; Gene_413; identified by MetaGeneAnnotator; putative [a.k.a. LOSG293_040610, Probable two-component transmembrane sensor, A0A081BGZ7]

Magnetococcus marinus

Mmc1_2112 - Histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: cvi:CV1579 probable two-component hybrid sensor and regulator [a.k.a. ABK44613.1, InterPro:IPR001789, IPR003018]

Mariprofundus ferrooxydans

SPV1_02437 - Probable two-component hybrid sensor and regulator; COG0784 FOG: CheY-like receiver [a.k.a. EAU55769.1, Q0F1Y1, Q0F1Y1_9PROT]

Marvinbryantia formatexigens

EET62526.1 - OmpA family protein; KEGG: cvi:CV1579 0.00029 probable two-component hybrid sensor and regulator [a.k.a. BRYFOR_05561, WP_006860361.1, GI:255269321]

Marvinbryantia formatexigens

EET62615.1 - Putative sodium/proline symporter; KEGG: azo:azo2412 6.4e-11 probable two-component system sensor protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. BRYFOR_05650, IPR001734, C6LAK8]

Marvinbryantia formatexigens

EET62120.1 - M protein repeat protein; KEGG: cvi:CV1579 8.2e-09 probable two-component hybrid sensor and regulator; Psort location: Cytoplasmic, score: 8.87 [a.k.a. BRYFOR_05784, C6LAY9_9FIRM, M protein repeat protein]

Nocardioides sp. JS614

Noca_0194 - PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sth:STH749 two-component sensor kinase, probably involved in phosphate sensing [a.k.a. ABL79739.1, nca:Noca_0194, InterPro:IPR003661]

Oceanicaulis sp. HTCC2633

EAP89722.1 - Probable two-component transmembrane sensor histidine kinasetranscription regulator protein; COG0642 Signal transduction histidine kinase [a.k.a. OA2633_10659, GI:83851867, EAP89722]

Oceanicaulis sp. HTCC2633

EAP90312.1 - Probable transmembrane two-component sensor kinase transcription regulator protein; COG0642 Signal transduction histidine kinase [a.k.a. OA2633_11445, A3UEK5_9RHOB, A3UEK5]

Pantoea vagans

ygiY - Probable two-component system sensor histidine kinase; Signal transduction histidine kinase [a.k.a. Pvag_3247, ADO11385.1, GI:308059213]

Ralstonia solanacearum GMI1000

RSc1075 - Probable two-component system sensor histidine kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD14777.1, HSSP:1I58, IPR007890]

Ralstonia solanacearum GMI1000

RSc1598 - Probable two-component transmembrane sensor histidine kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD15300.1, GOA:Q8XZ08, Q8XZ08_RALSO]

Ralstonia solanacearum GMI1000

RSc1735 - Probable two-component transmembrane sensor kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD15437.1, IPR013727, 1220573]

Ralstonia solanacearum GMI1000

RSp0220 - Probable two-component transmembrane sensor histidine kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD17371.1, HSSP:1I58, 1222351]

Ralstonia solanacearum GMI1000

RSp1454 - Probable two-component transmembrane sensor kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD18605.1, WP_011004702.1, 1JOY]

Ralstonia solanacearum GMI1000

RSp1553 - Probable transmembrane two-component sensor kinase transcription regulator protein; Miscellaneous; not classified regulator [a.k.a. CAD18704.1, Q8XPT4_RALSO, InterPro:IPR003661]

Ruminococcus gnavus

EDN76022.1 - Uncharacterized protein; KEGG: cvi:CV1579 7.6e-09 probable two-component hybrid sensor and regulator; COG: KOG0946 ER-Golgi vesicle-tethering protein p115; Psort location: Cytoplasmic, score:8.87 [a.k.a. RUMGNA_03645, GI:153793602, 153793602]

Ruminococcus lactaris

EDY33902.1 - Transporter, SSS family; KEGG: azo:azo2412 0.0016 probable two-component system sensor protein; COG: COG0591 Na+/proline symporter; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [a.k.a. RUMLAC_00271, 197299379, Transporter, SSS family]

Ruminococcus obeum ATCC29174

EDM85997.1 - OmpA family protein; KEGG: cvi:CV1579 0.0019 probable two-component hybrid sensor and regulator; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [a.k.a. RUMOBE_03367, IPR006665, GI:149830907]

Stenotrophomonas maltophilia K279a

Smlt3765 - Similarity:fasta; SDT3170; styphimuriumDT104; probable two-component system sensor histidine kinase; length 449 aa; id=29.9%; E()=4.4e-17; 462 aa overlap; query 27-450 aa; subject 6-449 aa [a.k.a. CAQ47174.1, CAQ47174, InterPro:IPR003661]

Stenotrophomonas maltophilia R5513

Smal_2343 - PFAM: histidine kinase internal region; KEGG: cvi:CV_0103 probable two-component system sensor protein [a.k.a. ACF52046.1, B4SLZ3_STRM5, B4SLZ3]

Xanthomonas albilineans

pilS - Probable two-component system sensor protein pils; Metabolism go:0008152; fimbria, pili, curli go:0009297 [a.k.a. XALc_0669, XALC_0669, CBA15187.1]

Xanthomonas albilineans

pilL - Probable two-component system sensor histidine kinase-response regulator hybrid protein pill; Metabolism go:0008152; fimbria, pili, curli go:0009297 [a.k.a. XALc_2238, XALC_2238, CBA16720.1]

Opitutus terrae

Oter_1811 - Histidine kinase; KEGG: rso:RS05068 probable composite two-component transcriptional regulatory (sensor histidine kinase and response regulator hybrid) transcription regulator protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ACB75095.1, InterPro:IPR013656, InterPro:IPR001789]

Bacillus clausii

ABC0495 - Two-component sensor histidine kinase; Probable gene remnant. Similar to the C-terminal region of Bacillus anthracis DNA-binding response regulator BA2212 (227 aa) TR:Q81R46; locus_tag:ABC0493 [a.k.a. BAD63035, bcl:ABC0495, Q5WKS0_BACSK]

Magnetococcus marinus

Mmc1_2113 - PFAM: CheB methylesterase; MCP methyltransferase, CheR-type; KEGG: cvi:CV1580 probable two-component hybrid sensor-regulator protein [a.k.a. ABK44614.1, A0L9H1, InterPro:IPR000673]

Nitratiruptor sp. SB1552

NIS_0117 - Two-component sensor histidine kinase; Probable gene remnant. Similar to Pelodictyon luteolum DSM 273 cytochrome c (167 aa) Plut_1674 [a.k.a. BAF69232, A6Q173, A6Q173_NITSB]

Ralstonia solanacearum GMI1000

phoR - Probable phosphate regulon two-component sensor kinase transcription regulator protein; Small molecule metabolism; central intermediary metabolism; phosphorus metabolism [a.k.a. RSc1535, CAD15237.1, GI:17428551]

Xanthomonas albilineans

ntrB - Probable two-component regulatory system sensor protein ntrb; Metabolism go:0008152; nitrogen metabolism go:0006807 [a.k.a. XALc_3090, XALC_3090, CBA17567.1]

Streptomyces avermitilis

mtrB - Putative two-component system sensor kinase; Probably essential TCR, PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [a.k.a. SAVERM_5064, SAV_5064, BAC72776.1]

Mycobacterium leprae

senX3 - Sensor-like histidine kinase senX3; Probably forms part of a two-component regulatory system senX3/regX3. Phosphorylates regX3 (Probable) [a.k.a. B2168_C3_247, ML2440, NP_302581.1]

Mycobacterium tuberculosis H37Rv

senX3 - Sensor-like histidine kinase senX3; Probably forms part of a two-component regulatory system senX3/regX3. Phosphorylates regX3 (Probable) [a.k.a. MTCY20G9.16, Rv0490, CCP43224.1]

Sphingomonas sp. SKA58

EAT06864.1 - Two-component system sensor histidine kinase/response regulator, hybrid ('one component system'); COG1215 Glycosyltransferases, probably involved in cell wall biogenesis [a.k.a. SKA58_11635, EAT06864, Q1N7B2_SPHSS]

Escherichia coli K12 W3110

yedV - Probable sensor-like histidine kinase YedV; Probable member of a two-component regulatory system YedW/YedV. Activates YedW by phosphorylation [a.k.a. b1968, JW1951, P76339]

Rhizobium sp. LPU83

kdpD - Two-component sensor histidine kinase protein (probably regulates osmosensitive potassium channel); High confidence in function and specificity [a.k.a. LPU83_4162, CDM59796.1, rhl:LPU83_4162]

Ralstonia pickettii 12J

Rpic_1899 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RSc1647 probable oxidative stress resistance two-component transmembrane sensor histidine kinase transcription regulator protein [a.k.a. ACD27034.1, rpi:Rpic_1899, 6288678]

Yersinia pestis CO92

creC - Similar to Myxococcus xanthus developmental histidine kinase sensor SasS TR:O52223 (EMBL:AF029787) (497 aa) fasta scores: E(): 1.4e-23, 28.2% id in 485 aa, and to Escherichia coli sensor protein CreC SW:CREC_ECOLI (P08401) (474 aa) fasta scores: E(): 0, 58.3% id in 470 aa. Probable sensor kinase protein of two-component regulatory system [a.k.a. YPO0895, CAL19562.1, InterPro:IPR003661]

Sinorhizobium medicae

Smed_5634 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMa0939 probable sensor histidine kinase of two-component system [a.k.a. ABR64375.1, YP_001314308, 150032260]

Xanthobacter autotrophicus

Xaut_3388 - Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMa0939 probable sensor histidine kinase of two-component system [a.k.a. ABS68617.1, A7IKS4, InterPro:IPR003661]

Pelagibaca bermudensis

EAU44547.1 - Probable sensor histidine kinase of two-component system; COG0642 Signal transduction histidine kinase [a.k.a. R2601_06138, GI:114541503, 114541503]

Ehrlichia ruminantium

Erum7860 - Uncharacterized protein; Probable response regulator component of a two-component regulatory system | len: 267 aa | Similar to many response regulators including cell cycle transcriptional regulators e.g. CTRA_CAUCR Q45994 Cell cycle transcriptional regulator (231 aa), fasta scores: E(): 4.4e-43, 54.626% identity in 227 aa overlap | Note that the sensor kinase component is absent/unattached | Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal | Similar to Erum3220, Erum6610, Erum6630 [a.k.a. ERWE_CDS_08310, CAH58520.1, GOA:Q5HA95]

Ehrlichia ruminantium

ntrX - Nitrogen assimilation regulatory protein NtrX; Probable response regulator component of a two-component regulatory system | len: 471 aa | Identical to Q93FR8 Hypothetical nitrogen assimilation regulatory protein (471 aa) from Ehrlichia ruminantium (Highway), fasta scores: E(): 5.7e-169, 100.000% identity in 471 aa overlap. Similar to many e.g. NTRC_ECOLI P06713 Nitrogen regulation protein NR(I) (469 aa) from Escherichia coli, fasta scores: E(): 1.2e-41, 33.120% identity in 468 aa overlap | Note that the sensor kinase component is absent/unattached | Contains Pfam match to entry PF00072 [...] [a.k.a. ERWE_CDS_06930, CAH58393.1, Erum6610]

Plesiocystis pacifica

EDM78546.1 - Probable serine/threonine kinase protein with two-component sensor domain; COG0515 Serine/threonine protein kinase [a.k.a. PPSIR1_14950, A6G6B7, A6G6B7_9DELT]

Plesiocystis pacifica

EDM75276.1 - Probable serine/threonine kinase protein with two-component sensor domain; COG0515 Serine/threonine protein kinase [a.k.a. PPSIR1_41259, A6GFS9, A6GFS9_9DELT]

Flavobacterium branchiophilum

CCB69848.1 - Probable two-component system response regulatory protein; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_1791, G2Z1R4_FLABF, WP_014084313.1]

Flavobacterium branchiophilum

CCB70280.1 - Probable two-component system response regulatory protein; 1.3 Sensors (signal transduction) [a.k.a. FBFL15_2260, GI:345530250, G2Z2V1_FLABF]

Bacillus subtilis

ykoH - Sensor histidine kinase YkoH; Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG [a.k.a. BSU13260, CAB13183.1, UniProtKB/Swiss-Prot:O34638]

Bacillus subtilis

yxjM - Sensor histidine kinase YxjM; Probable member of the two-component regulatory system YxjM/YxjL. May activate YxjL by phosphorylation [a.k.a. BSU38900, CAB15916.1, bsu:BSU38900]

Bacillus subtilis

yxdK - Sensor histidine kinase YxdK; Probable member of the two-component regulatory system YxdK/YxdJ. May activate YxdJ in response to the antibacterial protein LL-37 [a.k.a. BSU39650, B65E, CAB16001.1]

Haemophilus influenzae

narQ - Sensor protein NarQ homolog; Probable member of a two-component regulatory system. It is not known what protein it phosphorylates and in which regulatory pathway it acts, as the narL and other nar genes do not exist in H.influenzae [a.k.a. HI_0267, narX, AAC21933.1]

Yersinia pestis CO92

YPO3965 - Histidine kinase; Probable hybrid two-component system regulatory protein. CDS contains both sensor histidine kinase domain and response regulator receiver domain. C-terminus is similar to Rhizobium leguminosarum regulatory protein FixL TR:Q52824 (EMBL:Z70305) (641 aa) fasta scores: E(): 0,33.3% id in 519 aa, and to Pseudomonas syringae histidine protein kinase-response regulator hybrid protein CvgsY TR:Q9WWH9 (EMBL:AF133262) (671 aa) fasta scores: E(): 0,44.6% id in 383 aa [a.k.a. CAL22546.1, InterPro:IPR001789, InterPro:IPR003661]

Bacillus anthracis Sterne

lytS - Sensor protein LytS; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism [a.k.a. GBAA_5692, BA_5692, BAS5296]

Bacillus halodurans

citS - Sensor protein CitS; Member of the two-component regulatory system CitT/CitS. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex (By similarity) [a.k.a. BH3839, 10176464, WP_010899964.1]

Bacillus methanolicus MGA3

lytS - Sensor protein LytS; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism [a.k.a. BMMGA3_02975, AIE59055.1, AIE59055]

Bacillus subtilis

lytS - Sensor protein LytS; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism [a.k.a. BSU28930, CAB14853.1, 2635358]

Enterococcus faecalis V583

lytS - Sensor protein LytS; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism [a.k.a. EF_3197, AAO82869.1, GI:29345113]

Oceanobacillus iheyensis

lytS - Sensor protein LytS; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism [a.k.a. OB1642, 22777325, BAC13598]

Saccharothrix espanaensis

pdtaS - Putative sensor histidine kinase; Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [a.k.a. BN6_75790, CCH34804.1, putative sensor histidine kinase]

Staphylococcus epidermidis ATCC12228

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. SE_2011, AAO05652.1, Sensor protein LytS]

Staphylococcus epidermidis RP62A

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. SERP2024, AAW52842.1, LYTS_STAEQ]

Staphylococcus haemolyticus

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. SH0613, BAE03922.1, GI:68446338]

Staphylococcus saprophyticus

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. SSP0464, BAE17609.1, Q4A009]

Streptococcus agalactiae NEM316

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. gbs0180, NP_734650.1, LYTS_STRA3]

Streptococcus mutans UA159

lytS - Sensor protein LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism [a.k.a. SMU_577, AAN58318.1, GI:24376954]

Bacteroides fragilis NCTC 9343

BF9343_3941 - Putative two-component system sensor histidine kinase/response regulator fusion protein; 1 probable transmembrane helix predicted for BF4047 by TMHMM2.0 at aa 190-212 [a.k.a. BF9343_3941, bfs:BF9343_3941, conserved hypothetical protein (fragment)]

Staphylococcus epidermidis RP62A

SERP2405 - Uncharacterized sensor-like histidine kinase SERP2405; Probable member of the two-component regulatory system SERP2405/SERP2406. May activate SERP2406 by phosphorylation (By similarity) [a.k.a. AAW53252.1, Y2405_STAEQ, WP_002505316.1]

Sinorhizobium meliloti

SM_b20164 - Conserved hypothetical protein; probable two-component response regulator receiver,,putative histidine kinase, autoinducer sensor kinase/phosphatase luxQ [a.k.a. CAC48564.1, InterPro:IPR001789, InterPro:IPR003661]

Mycobacterium smegmatis MC2155

mtrB - Sensor histidine kinase MtrB; Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). MtrB may be active only at septa where it promotes MtrA phosphorylation and MtrA regulon expression, probably playing a role in cell division [a.k.a. MSMEG_1875, MSMEI_1836, AFP38308.1]

Bacillus subtilis

liaS - Sensor histidine kinase LiaS; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation [a.k.a. BSU33090, yvqE, CAB15299.1]

Bacillus methanolicus MGA3

yvfT - Sensor histidine kinase YvfT; Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation [a.k.a. BMMGA3_09485, AIE60295.1, Sensor histidine kinase YvfT]

Bacillus subtilis

ybdK - Sensor histidine kinase YbdK; Member of the two-component regulatory system YbdK/YbdJ. Probably activates YbdJ by phosphorylation [a.k.a. BSU02010, CAB11995.1, SubtiList:BG12724]

Bacillus subtilis

ycbM - Sensor histidine kinase YcbM; Member of the two-component regulatory system YcbM/YcbL. Probably activates YcbL by phosphorylation [a.k.a. BSU02560, CAB12050.2, NP_388138]

Bacillus subtilis

yesM - Sensor histidine kinase YesM; Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation [a.k.a. BSU06950, CAB12514.1, 936078]

Bacillus subtilis

yfiJ - Sensor histidine kinase YfiJ; Member of the two-component regulatory system YfiJ/YfiK. Probably activates YfiK by phosphorylation [a.k.a. BSU08290, CAB12658.1, 2633153]

Bacillus subtilis

yhcY - Sensor histidine kinase YhcY; Member of the two-component regulatory system YhcY/YhcZ. Probably activates YhcZ by phosphorylation [a.k.a. BSU09320, CAB12760.1, IPR003018]

Bacillus subtilis

yrkQ - Sensor histidine kinase YrkQ; Member of the two-component regulatory system YrkQ/YrkP. Probably activates YrkP by phosphorylation [a.k.a. BSU26420, CAB14583.1, GI:2635087]

Bacillus subtilis

yvfT - Sensor histidine kinase YvfT; Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation [a.k.a. BSU34070, CAB15412.2, Sensor histidine kinase YvfT]

Bacillus subtilis

yvcQ - Sensor histidine kinase YvcQ; Member of the two-component regulatory system YvcQ/YvcP. Probably activates YvcP by phosphorylation [a.k.a. BSU34710, CAB15476.1, Two-component sensor histidine kinase [YvcP]]

Mycobacterium tuberculosis H37Rv

mtrB - Sensor histidine kinase MtrB; Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals. Autophosphorylates and transfers phosphate to MtrA in vitro. Overexpression of MtrA alone decreases bacterial virulence in mouse infection; co-expression of MtrA and MtrB restores normal bacterial growth, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA. Probably plays a role in cell division [a.k.a. Rv3245c, MTCY20B11.20c, CCP46064.1]

Bacillus subtilis

comP - Sensor histidine kinase ComP; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation [a.k.a. BSU31690, CAB15157.2, Q99027]

Staphylococcus epidermidis ATCC12228

arlS - Signal transduction histidine-protein kinase ArlS; Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity) [a.k.a. SE_1099, AAO04696.1, ARLS_STAES]

Staphylococcus epidermidis RP62A

Staphylococcus haemolyticus

Staphylococcus saprophyticus

Amycolatopsis japonica

pdtaS - Putative sensor histidine kinase pdtaS; Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [a.k.a. AJAP_05205, AIG73961.1, aja:AJAP_05205]

Streptomyces davawensis

Streptomyces glaucescens

Burkholderia cenocepacia

BCAS0589 - Two-component regulatory system, sensor kinase protein; Similar to Ralstonia solanacearum probable transmembrane protein rs03653 SWALL:Q8XXM5 (EMBL:AL646068) (200 aa) fasta scores: E(): 1.2e-22, 71.27% id in 94 aa; N terminus only. Truncation of C-terminal 104 amino acids; frameshift after codon 50 [a.k.a. putative membrane protein (fragment), B4ENY3, 2.7.13.3]

Staphylococcus aureus

AID38640.1 - Uncharacterized sensor-like histidine kinase SAOUHSC_00185; Probable member of the two-component regulatory system SAOUHSC_00185/SAOUHSC_00184. May activate SAOUHSC_00184 by phosphorylation (By similarity) [a.k.a. SAOUHSC_00185, SAXN108_0199, WP_000127982.1]

Staphylococcus epidermidis ATCC12228

SE_0166 - Uncharacterized sensor-like histidine kinase SE_0166; Probable member of the two-component regulatory system SE_0166/SE_0165. May activate SE_0165 by phosphorylation (By similarity) [a.k.a. AAO03763.1, NP_763721, WP_002469221.1]

Mycobacterium tuberculosis H37Rv

tcrY - Probable sensor histidine kinase TcrY; Member of the two-component regulatory system TcrY/TcrX. Activates TcrX by phosphorylation [a.k.a. Rv3764c, CCP46591.1, O69729]

Pseudoxanthomonas suwonensis 111

Psesu_2897 - Multi-sensor hybrid histidine kinase; KEGG: xca:xccb100_3154 two-component system sensor/response regulator fusionprotein, probable; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; response regulator receiver [a.k.a. ADV28721.1, InterPro:IPR001789, IPR003018]

Pectobacterium sp. SCC3193

pmrB - Sensor histidine kinase PmrB; Member of the two-component regulatory system PmrB/PmrA involved in regulation of virulence. Functions probably as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PmrA in response to external pH and iron [a.k.a. W5S_4174, AFI92230.1, WP_014701629.1]

Alcanivorax borkumensis

chpA - ChpA two-component hybrid sensor and regulator, putative identified by match to TIGR protein family HMMTIGR01387 InterPro: Histidine kinase C-terminal still frameshift probable component of chemotactic signal transduction system; Specificity unclear [a.k.a. ABO_0104, CAL15552.1, InterPro:IPR001789]

Yersinia enterocolitica 8081

YE0317 - Similar to many two-component system sensor proteins including: Escherichia coli protein FecR controlling iron dicitrate transport SWALL:FECR_ECOLI (SWALL:P23485) (317 aa) fasta scores: E(): 3.5e-10, 24.24 id in 297 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa1301 SWALL:Q9I443 (EMBL:AE004559) (327 aa) fasta scores: E(): 3.1e-37, 39.74 38d in 312 aa,and to Agrobacterium tumefaciens transmembrane sensor Atu5310 or agr_pat_bx251 SWALL:Q8UK14 (EMBL:AE008953) (311 aa) fasta scores: E(): 5.5e-17, 27.5 38d in 309 aa [a.k.a. CAL10449.1, YP_001004697.1, A1JIL0_YERE8]

Oryza sativa

ERS1 - Probable ethylene response sensor 1; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling [a.k.a. Os03g0701700, LOC_Os03g49500, OsJ_12251]

Oryza sativa

ERS2 - Probable ethylene response sensor 2; Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May play a role in the regulation of flowering by upregulating GI (GIGANTEA) and RCN1 and regulate starch accumulation by down- regulating the alpha-amylase AMY3D [a.k.a. Os05g0155200, P0431G05.6, OsJ_17173]

Burkholderia pseudomallei K96243

BPSL1634 - Putative two-component regulatory system, sensor kinase protein; Similar to Escherichia coli sensor protein RcsC or b2218 SWALL:RCSC_ECOLI (SWALL:P14376) (949 aa) fasta scores: E(): 7.1e-44, 27.18% id in 986 aa, and to Ralstonia solanacearum probable capsular synthesis regulatory rsp1622 or rs02179 SWALL:Q8XPL6 (EMBL:AL646086) (1098 aa) fasta scores: E(): 2.9e-52, 28.9% id in 993 aa.Note: This CDS appears to have a histidine kinase domain and a response regulator domain also [a.k.a. CAH35633.1, Q63UG8_BURPS, InterPro:IPR001789]

Burkholderia pseudomallei K96243

BPSS1876 - Putative sensor kinase/response regulator fusion protein; N-terminal region similar to Pseudomonas aeruginosa probable two-component response regulator pa3702 SWALL:Q9HXT9 (EMBL:AE004789) (347 aa) fasta scores: E(): 3.7e-29, 64.92% id in 134 aa, C-terminal region to Caulobacter crescentus sensory box histidine kinase, putative cc3327 SWALL:Q9A377 (EMBL:AE005994) (761 aa) fasta scores: E(): 9.5e-22, 37.61% id in 226 aa, and in full length to Mycobacterium leprae sensor-like histidine kinase SenX3 or ml2440 or b2168_c3_247 SWALL:SEX3_MYCLE (SWALL:P54883) (443 aa) fasta scores: E(): 1.9e- [...] [a.k.a. CAH39353.1, InterPro:IPR001789, InterPro:IPR003661]

Syntrophobacter fumaroxidans

Sfum_2638 - Signal transduction histidine kinase; KEGG: dps:DP1924 similar to two-component system sensory/regulatory protein (Ntr family), probably cold-shock inducible; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, dimerisation/phosphoacceptor; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein [a.k.a. ABK18316.1, InterPro:IPR013656, InterPro:IPR013655]

Rhodopirellula baltica

ntrB - Probable nitrogen regulation protein ntrB; PMID: 7553451 best DB hits: BLAST: pir:A82630; two-component system, sensor protein XF1849 [imported] -; E=1e-11 pir:S35265; ntrB protein - Azospirillum brasilense ----- embl:; E=1e-11 swissprot:P45670; NTRB_AZOBR NITROGEN REGULATION PROTEIN NTRB; E=3e-11 COG: XF1849; COG0642 Sensory transduction histidine kinases; E=1e-12 PFAM: PF00672; HAMP domain; E=9.9e-11 PF00512; His Kinase A (phosphoacceptor) doma; E=0.00015 PF02518; Histidine kinase-, DNA gyrase B-, p; E=4.8e-20 [a.k.a. RB11037, NP_869752.1, rba:RB11037]

Staphylococcus aureus

graS - Sensor histidine kinase GraS; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR. GraR/GraS up-regulates the dlt operon and many other genes, such as other global regulators, adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confe [...] [a.k.a. SAOUHSC_00666, AID39168.1, SAXN108_0727]

Staphylococcus epidermidis ATCC12228

Staphylococcus epidermidis RP62A

Staphylococcus haemolyticus

Staphylococcus saprophyticus

Rhodopirellula baltica

RB6818 - PMID: 9665876 best DB hits: BLAST: pir:D71379; probable sensory transduction histidine kinase -; E=5e-23 embl:CAB64771.1; (AJ007794) kin1 [Bacillus cereus] -----; E=1e-21 pir:B69863; two-component sensor histidine kinase homolog ykrQ -; E=2e-21 COG: BS_ykrQ_3; COG0642 Sensory transduction histidine kinases; E=2e-22 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=6.1e-12 PF02518; Histidine kinase-, DNA gyrase B-, p; E=8.6e-32 [a.k.a. NP_867478.1, 1795087, Sensory transduction histidine kinase]

Bacteroides helcogenes

Bache_2626 - COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; InterPro IPR001173; KEGG: bfr:BF1995 putative glycosyltransferase; PFAM: glycosyl transferase family 2; SPTR: Two-component system sensor histidine kinase/response regulator; PFAM: Glycosyl transferase family 2 [a.k.a. ADV44582.1, bhl:Bache_2626, E6SWC1]

Burkholderia pseudomallei K96243

BPSS0717 - Putative membrane protein; Similar to Ralstonia solanacearum probable transmembrane protein rsc0982 or rs04310 SWALL:Q8Y0R1 (EMBL:AL646062) (429 aa) fasta scores: E(): 1.4e-83, 53.42% id in 423 aa, and to Rhizobium meliloti putative two-component sensor histidine kinase protein rb1162 or smb20868 SWALL:Q92UG9 (EMBL:AL603646) (1229 aa) fasta scores: E(): 1e-09, 26.43% id in 435 aa [a.k.a. CAH38177.1, putative membrane protein, InterPro:IPR007895]

Azoarcus sp. BH72

azo2971 - Histidine kinase; Putative two-component sensor histidine kinase,only very low similarity to SWISSPROT: sprot|DEGS_BACBR (13% Bacillus brevis, DegS) InterPro: IPR003661 His_kinA_N. Pfam: PF00672 HAMP domain. PF02518 Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase TMHMM reporting 2 transmembrane helices. Sensor protein degS (EC 2.7.3.-). INVOLVED IN A SENSORY TRANSDUCTION PATHWAY THAT AFFECT THE PRODUCTION OF ENZYMES THAT DEGRADE POLYMERIC CARBON AND NITROGEN SOURCES. DEGS PROBABLY ACTS AS A KINASE THAT PHOSPHORYLATES DEGU; Function unclear [a.k.a. CAL95587.1, InterPro:IPR003661, IPR005467]

Streptomyces coelicolor

SCO3012 - SCE33.14c, probable two-component system histidine kinase, len: 688 aa; similar to TR:O05890 (EMBL:Z95121) Mycobacterium tuberculosis MtrB, 567 aa; fasta scores: opt: 1355 z-score: 1302.5 E(): 0; 48.9% identity in 515 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-) fasta scores: opt: 560 z-score: 542.0 E(): 9.8e-23; 31.1% identity in 460 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase. Contains possible hydrophobic membrane spanning regions [a.k.a. SCE33.14c, NP_627234.1, 21221455]

Ferrimonas balearica

Fbal_0120 - COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; InterPro IPR001173; KEGG: avn:Avin_05330 glycosyl transferase, family 2; PFAM: glycosyl transferase family 2; SPTR: A1ZS81 Two-component system sensor histidine kinase/response regulator, hybrid; PFAM: Glycosyl transferase family 2 [a.k.a. ADN74334.1, Glycosyl transferase family 2, fbl:Fbal_0120]

Burkholderia pseudomallei K96243

BPSS0136 - Putative membrane protein; Similar in its full length to Ralstonia solanacearum probable transmembrane protein rsc3143 or rs00460 SWALL:Q8XUP3 (EMBL:AL646073) (459 aa) fasta scores: E(): 1e-97, 58.48% id in 448 aa, and to Bradyrhizobium japonicum two-component hybrid sensor and regulator blr5677 SWALL:BAC50942 (EMBL:AP005955) (941 aa) fasta scores: E(): 1.7e-17, 32.38% id in 315 aa [a.k.a. CAH37581.1, WP_004531553.1, GI:52211586]

Streptococcus agalactiae NEM316

dltS - Sensor protein DltS; Member of the two-component regulatory system DltS/DltR. Regulates the expression of the dlt operon. Probably phosphorylates DltR [a.k.a. gbs1834, NP_736268.1, Q8VM68]

Bacillus methanolicus MGA3

desK - Sensor histidine kinase DesK; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation [a.k.a. BMMGA3_08025, AIE60011.1, WP_004433956.1]

Bacillus subtilis

citS - Sensor protein CitS; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex [a.k.a. BSU07580, yflR, CAB12587.1]

Staphylococcus epidermidis ATCC12228

vraS - Sensor protein VraS; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates VraR by phosphorylation (By similarity) [a.k.a. SE_1570, AAO05169.1, 1055738]

Staphylococcus epidermidis RP62A

Staphylococcus haemolyticus

Staphylococcus saprophyticus

Amycolatopsis japonica

dnrJ - May form, with DnrI, a two-component regulatory system for daunorubicin biosynthesis genes. This protein probably acts as a sensor protein; Belongs to the DegT/DnrJ/EryC1 family [a.k.a. AJAP_32020, AIG79218.1, 2.6.1.-]

Streptococcus pneumoniae R6

ciaH - Sensor protein CiaH; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [a.k.a. spr0708, AAK99512.1, sensor histidine kinase CiaH]

Streptococcus pneumoniae TIGR4

ciaH - Sensor protein CiaH; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR (By similarity) [a.k.a. SP_0799, AAK74936.1, P0A4I5]

Escherichia coli K12 W3110

Burkholderia pseudomallei K96243

irlS - Sensor protein IrlS; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation (By similarity) [a.k.a. BPSS1039, CAH38500.1, InterPro:IPR006290]

Staphylococcus aureus

srrB - Sensor protein SrrB; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates SrrA (By similarity) [a.k.a. SAOUHSC_01585, AID39955.1, SAXN108_1514]

Pseudomonas aeruginosa

kinB - Alginate biosynthesis sensor protein KinB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. KinB functions as a membrane-associated protein kinase that phosphorylates AlgB, probably in response to environmental signals [a.k.a. KFL10070.1, DR97_2862, paeb:NCGM1900_6343]

Pseudomonas knackmussii

kinB - Alginate biosynthesis sensor protein kinB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. KinB functions as a membrane-associated protein kinase that phosphorylates AlgB, probably in response to environmental signals [a.k.a. PKB_5804, CDF87109.1, WP_043257888.1]

Stenotrophomonas maltophilia K279a

Smlt0107 - Putative sensor histidine kinase transcriptional regulatory protein two-component regulator; Codons 50 to the C-terminus are similar to codons 330 to 1090 of Bordetella bronchiseptica (Alcaligenes bronchisepticus) BvgS virulence sensor protein bvgs precursor (ec 2.7.13.3). UniProt:P26762 (1238 aa) fasta scores: E()=1.8e-38, 30.670% id in 776 aa, and codons 400 to the C-terminus are similar to the N-terminus to codon 430 of Chromobacterium violaceum probable sensory box histidine kinase/response regulator (ec 2.7.3.-). UniProt:Q7NWX7 (552 aa) fasta scores: E()=2.7e-42, 40.244% id in 410 [...] [a.k.a. CAQ43717.1, InterPro:IPR001789, GI:190010109]

Escherichia coli K12 W3110

Escherichia coli O157H7

Staphylococcus aureus

nreB - Oxygen sensor histidine kinase NreB; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity) [a.k.a. SAOUHSC_02676, AID41088.1, SAXN108_2647]

Staphylococcus carnosus

Staphylococcus epidermidis ATCC12228

Staphylococcus epidermidis RP62A

Staphylococcus haemolyticus

Bacillus methanolicus MGA3

resE - Sensor histidine kinase ResE; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD [a.k.a. BMMGA3_10970, AIE60590.1, AIE60590]

Bacillus subtilis

Burkholderia cenocepacia

BCAM0379 - Hybrid two-component system kinase-response regulator protein; Similar to Chromobacterium violaceum probable sensor histidine kinase/response regulator (ec 2.7.3.-). UniProt:Q7NVX8 (734 aa) fasta scores: E()=7.7e-24, 26.592% id in 628 aa; truncated by 100+ amino acids at C terminus [a.k.a. CAR54235.1, InterPro:IPR001789, InterPro:IPR003661]

Mycobacterium leprae

prrB - Sensor-type histidine kinase PrrB; Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates PrrA (By similarity) [a.k.a. MLCB57.60c, ML2124, NP_302403.1]

Mycobacterium tuberculosis H37Rv

Bacillus methanolicus MGA3

malK - Sensor histidine kinase MalK; Member of a two-component regulatory system MalK/MalR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates MalR by phosphorylation [a.k.a. BMMGA3_15895, AIE61532.1, 662720322]

Bacillus subtilis

yufL - Sensor histidine kinase MalK; Member of a two-component regulatory system MalK/MalR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates MalR by phosphorylation [a.k.a. BSU31520, malK, CAB15141.1]

Pseudomonas protegens CHA0

gacS3 - Sensor histidine kinase GacS; Member of the two-component regulatory system GacA/GacS which controls the expression of secondary metabolites and extracellular products. Activates GacA by phosphorylation (Probable). GacA acts (probably primarily) by activating expression of CsrA1 and CsrA2 antagonist small RNAs (sRNA) RsmX, RsmY and RsmZ which bind to and prevent translation repression by CsrA1 and CsrA2. Involved in the regulation of secondary metabolism and in the synthesis of the antifungal factors cyanide, 2,4-diacetylphloroglucinol and pyoluteorin. Exercises positive post-transcrip [...] [a.k.a. lemA, gacS, PFLCHA0_c45240]

Amycolatopsis japonica

dosT1 - Hypoxia sensor histidine kinase response regulator DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR) [a.k.a. AJAP_17145, AIG76297.1, A0A075UQ47_9PSEU]

Amycolatopsis japonica

dosT2 - Hypoxia sensor histidine kinase response regulator DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR) [a.k.a. AJAP_18730, AIG76611.1, A0A075UW25]

Kutzneria albida

KALB_3574 - Hypoxia sensor histidine kinase response regulator dosT; Interacts with the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to devR (dosR) [a.k.a. AHH96938.1, 0020037, GO:0016021]

Mycobacterium tuberculosis H37Rv

dosT - Hypoxia sensor histidine kinase response regulator DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR) [a.k.a. Rv2027c, CCP44800.1, two component sensor histidine kinase DosT]

Saccharothrix espanaensis

BN6_37760 - Hypoxia sensor histidine kinase response regulator dosT; Interacts with the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to devR (dosR) [a.k.a. CCH31068.1, GI:407883425, K0K3F5_SACES]

Pseudomonas putida F1

todS - Sensor histidine kinase TodS; Member of the two-component regulatory system TodS/TodT involved in the regulation of toluene degradation. Phosphorylates TodT via a four-step phosphorelay in response to toluene (Probable) [a.k.a. Pput_2872, ABQ79003.1, ABQ79003]

Bacillus methanolicus MGA3

yycG - Sensor histidine kinase YycG; Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [a.k.a. BMMGA3_16595, AIE61672.1, 662720462]

Bacillus subtilis

yvrG - Sensor histidine kinase YvrG; Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon. Probably activates YvrH by phosphorylation [a.k.a. BSU33210, CAB15311.2, WP_003243980.1]

Escherichia coli O157H7

qseE - Sensor histidine kinase QseE; Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Autophosphorylates in response to epinephrine, sulfate or phosphate and then probably transfers its phosphate group to QseF [a.k.a. yfhK, Z3833, ECs3422]

Kutzneria albida

KALB_3341 - Redox sensor histidine kinase response regulatordevS; Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to devR (dosR) [a.k.a. AHH96708.1, 0020037, 0018106]

Mycobacterium tuberculosis H37Rv

devS - Redox sensor histidine kinase response regulator DevS; Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) [a.k.a. Rv3132c, dosS, CCP45942.1]

Streptomyces davawensis

devS - Redox sensor histidine kinase response regulator devS; Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to devR (dosR) [a.k.a. BN159_8108, CCK32486.1, CCK32486]

Staphylococcus aureus

arlS - Signal transduction histidine-protein kinase ArlS; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes [...] [a.k.a. SAOUHSC_01419, SAXN108_1433, AID39874.1]

Xanthomonas campestris campestris

rpfC - Sensory/regulatory protein RpfC; Member of the two-component regulatory system RpfG/RpfC, which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF), which is essential for cell- cell signaling. RpfC is probably a sensor of environmental signals, including DSF, which is autophosphorylated at a histidine residue in response to the signal. Then, probably activates RpfG via a four-step phosphorelay. May also negatively regulate the production of DSF, independently of RpfG (By similarity) [a.k.a. XCC1856, xcc-b100_2144, CAP51497.1]

Escherichia coli K12 W3110

Campylobacter jejuni NCTC11168

flgS - Original (2000) note: Cj0793, probable signal transduction histidine kinase, len: 339 aa; similar to e.g. the C-terminus of ATOS_ECOLI sensor protein ATOS (608 aa), fasta scores; opt: 357 z-score: 408.3 E(): 1.9e-15,33.3% identity in 222 aa overlap. 42.4% identity to HP0244. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain; Updated (2006) note: Characterised within Campylobacter jejuni and Helicobacter pylori. Putative not added to product function. Literature search identified papers linking Cj0793 and Cj1024 to a two-component signal transduction system (Fl [...] [a.k.a. Cj0793, CAL34921.1, GOA:Q0PA97]

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