searching ... STRING: functional protein association networks

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1929 matches

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organism

protein

Escherichia coli K12

ydaV - Rac prophage; Putative DNA replication factor. [a.k.a. b1360, AAC74442.1, 945926, Putative replication protein]

Homo sapiens

MCRS1 - Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U). [a.k.a. ENST00000548602, Q96EZ8, MCRS1-213]

Mus musculus

Mcrs1 - Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U). [a.k.a. R-MMU-5696398, XP_030104500.1, A0A2R8VH87]

Saccharomyces cerevisiae

OCA6 - Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT. [a.k.a. YDR067C, S000002474, Tyrosine-protein phosphatase OCA6]

Saccharomyces cerevisiae

RIE1 - Uncharacterized RNA-binding protein YGR250C; Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress. [a.k.a. YGR250C, NP_011766, 853165]

Saccharomyces cerevisiae

CUB1 - UPF0662 protein YPL260W; Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress; Belongs to the UPF0662 family. [a.k.a. YPL260W, Q7LGU3, YP260_YEAST]

Saccharomyces cerevisiae

HBN1 - Putative nitroreductase HBN1; Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress. [a.k.a. YCL026C-B, D6VQY9, Putative nitroreductase HBN1]

Saccharomyces cerevisiae

YMR315W - Uncharacterized protein YMR315W; Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress. [a.k.a. S000004932, 4932.YMR315W, AAS56317.1]

Saccharomyces cerevisiae

GYL1 - Probable GTPase-activating protein GYL1; Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication. [a.k.a. YMR192W, YMR192W_mRNA, Q04322]

10)

Saccharomyces cerevisiae

HSP31 - Glutathione-independent glyoxalase HSP31; Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress; Belongs to the peptidase C56 family. HSP31-like subfamily. [a.k.a. YDR533C, D9719.36, 1QVV]

11)

Saccharomyces cerevisiae

RTK1 - Probable serine/threonine-protein kinase RTK1; Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress. [a.k.a. YDL025C, S000002183, 4932.YDL025C]

12)

Saccharomyces cerevisiae

TAN1 - Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress. [a.k.a. YGL232W, UPI000013B133, sce:YGL232W]

13)

Saccharomyces cerevisiae

EMI2 - Putative glucokinase-2; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; Belongs to the hexokinase family. [a.k.a. YDR516C, putative glucokinase, 2.7.1.2]

14)

Saccharomyces cerevisiae

MRX14 - Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress. [a.k.a. YDR115W, S000002522, 5MRC]

15)

Saccharomyces cerevisiae

YNL120C - Putative uncharacterized protein YNL120C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene. [a.k.a. S000005064, 4932.YNL120C, CAA93387.1]

16)

Saccharomyces cerevisiae

SMF3 - Iron transporter SMF3; Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress. [a.k.a. YLR034C, YLR034C_mRNA, NP_013134]

17)

Saccharomyces cerevisiae

TMA20 - Translation machinery-associated protein 20; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress; Belongs to the TMA20 family. [a.k.a. YER007C-A, D3DLQ4, RBF20]

18)

Saccharomyces cerevisiae

TMA22 - Translation machinery-associated protein 22; Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress; Belongs to the DENR family. [a.k.a. YJR014W, RBF22, CAA60937.1]

19)

Saccharomyces cerevisiae

YIL020C-A - Putative uncharacterized protein YIL020C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918, partially overlaps ORF RPB3/YIL021W. [a.k.a. YIL20_YEAST, UPI000176C74F, A0A023PXM7]

20)

Saccharomyces cerevisiae

YGL042C - Putative uncharacterized protein YGL042C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1. [a.k.a. YGL042C_mRNA, S000003010, P53181]

1929 matches

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