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BEAF-32 - Boundary element-associated factor of 32kD (BEAF-32) is a DNA-binding protein with binding sites near transcription start sites. BEAF-32 roles include chromatin domain insulator function, gene regulation and genome organization
[a.k.a. FBgn0015602, Dmel_CG10159, CG10159]
Upf1 - Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity)
[a.k.a. FBgn0030354, CG1559, Upf1-PB]
© STRING Consortium 2020
SIB - Swiss Institute of Bioinformatics
CPR - Novo Nordisk Foundation Center Protein Research
EMBL - European Molecular Biology Laboratory
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