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RUNX1 - Runt-related transcription factor 1; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. Controls the [...]
[a.k.a. LOC101928269, LOC100506403, AML1]
ENSP00000482514 - Digeorge syndrome critical region gene 6; Protein DGCR6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family
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SIB - Swiss Institute of Bioinformatics
CPR - Novo Nordisk Foundation Center Protein Research
EMBL - European Molecular Biology Laboratory
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