Full Link:
STRINGSTRING
CD14 CD14 LY96 LY96 HLA-DRA HLA-DRA SNAPIN SNAPIN NGF NGF TBC1D8B TBC1D8B HLA-DQA2 HLA-DQA2 TXNDC5 TXNDC5 AP1S2 AP1S2 GJA1 GJA1 DNM2 DNM2 GNS GNS NECAP1 NECAP1 CD3G CD3G CTNND1 CTNND1 CTSZ CTSZ TGOLN2 TGOLN2 RAB5C RAB5C WASL WASL M6PR M6PR SGIP1 SGIP1 ARPC5 ARPC5 DOCK4 DOCK4 SYT8 SYT8 RAB5A RAB5A APOB APOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M6PRMannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (277 aa)
CTSZCathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity (303 aa)
WASLWiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa)
APOBApolipoprotein B (including Ag(x) antigen); Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor (4563 aa)
GNSGlucosamine (N-acetyl)-6-sulfatase (552 aa)
RAB5ARAB5A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed-10818110, PubMed-14617813, PubMed-16410077, PubMed-15378032). Contributes to the regulation of f [...] (215 aa)
GJA1Gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...] (382 aa)
LY96Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS) (PubMed-17803912, PubMed-17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed-11160242, PubMed-11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed-10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed-10359581) (160 aa)
CD14CD14 molecule; Coreceptor for bacterial lipopolysaccharide (PubMed-1698311, PubMed-23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed-20133493, PubMed-23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed-8612135). Acts as a coreceptor for TLR2-TLR6 heterodimer in response to diacylated lipopeptides and for TLR2-TLR1 heterodimer in response to triacylated l [...] (375 aa)
AP1S2Adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (157 aa)
NECAP1NECAP endocytosis associated 1; Involved in endocytosis (275 aa)
RAB5CRAB5C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (216 aa)
DNM2Dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed-12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity) (870 aa)
TBC1D8BTBC1 domain family, member 8B (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1120 aa)
ARPC5Actin related protein 2/3 complex, subunit 5, 16kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (151 aa)
SNAPINSNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step [...] (136 aa)
NGFNerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed-20164177) (241 aa)
SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1; May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity) (828 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for pres [...] (255 aa)
TXNDC5Thioredoxin domain containing 5 (endoplasmic reticulum); Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity) (432 aa)
SYT8Synaptotagmin VIII; Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity) (401 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presen [...] (254 aa)
CTNND1Catenin (cadherin-associated protein), delta 1; Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage (968 aa)
TGOLN2Trans-golgi network protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network (453 aa)
DOCK4Dedicator of cytokinesis 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP (1966 aa)
CD3GCD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction (182 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (2%)