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ZNF732 ZNF732 PHLPP1 PHLPP1 HSPA5 HSPA5 PHLPP2 PHLPP2 LRRK2 LRRK2 GART GART ANKS4B ANKS4B MYO7B MYO7B LRGUK LRGUK USH1C USH1C NNT NNT
"ANKS4B" - Ankyrin repeat and sterile alpha motif domain containing 4B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B; As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed-26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity) (417 aa)    
Predicted Functional Partners:
USH1C
Usher syndrome 1C (autosomal recessive, severe); Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips ( [...] (899 aa)
     
 
  0.811
MYO7B
Myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable) (2116 aa)
     
 
  0.784
LRRK2
Leucine-rich repeat kinase 2; Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (C [...] (2527 aa)
     
 
  0.651
GART
Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (1010 aa)
   
 
  0.642
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser-657’ of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser- 473’ of Akt triggers apoptosis an [...] (1323 aa)
     
 
  0.612
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT2 and AKT3, ’Ser-660’ of PRKCB and ’Ser-657’ of PRKCA (PubMed-15808505, PubMed-17386267, PubMed-18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily [...] (1717 aa)
     
 
  0.612
ZNF732
Zinc finger protein 732; May be involved in transcriptional regulation (585 aa)
     
 
  0.567
HSPA5
Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (654 aa)
     
 
  0.548
LRGUK
Leucine-rich repeats and guanylate kinase domain containing; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development (825 aa)
     
 
  0.509
NNT
Nicotinamide nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (1086 aa)
     
 
    0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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