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DCTN4 DCTN4 DCTN1 DCTN1 ACTR10 ACTR10 ACTR1B ACTR1B DCTN6 DCTN6 DYNC1H1 DYNC1H1 DCTN5 DCTN5 DCTN2 DCTN2 TUBB4B TUBB4B ACTR1A ACTR1A HSP90AA1 HSP90AA1
"ACTR1A" - ARP1 actin-related protein 1 homolog A, centractin alpha in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)    
Predicted Functional Partners:
DCTN2
Dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
     
  0.999
DCTN5
Dynactin 5 (p25) (182 aa)
     
  0.997
DCTN1
Dynactin 1; Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (1278 aa)
     
  0.995
DCTN4
Dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (467 aa)
     
  0.991
DCTN6
Dynactin 6 (190 aa)
     
  0.985
DYNC1H1
Dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4646 aa)
     
  0.979
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
     
0.977
ACTR10
Actin-related protein 10 homolog (S. cerevisiae) (417 aa)
     
0.965
TUBB4B
Tubulin, beta 4B class IVb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (445 aa)
     
  0.963
HSP90AA1
Heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide [...] (854 aa)
     
  0.962
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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