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LILRB1 LILRB1 TAPBP TAPBP LILRB2 LILRB2 B2M B2M KIR2DL2 KIR2DL2 HLA-B HLA-B KLRD1 KLRD1 HLA-C HLA-C CD8A CD8A KIR3DL1 KIR3DL1 HLA-DQA2 HLA-DQA2
"HLA-B" - Major histocompatibility complex, class I, B in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
HLA-BMajor histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (362 aa)    
Predicted Functional Partners:
B2M
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (119 aa)
     
  0.999
KIR3DL1
Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis (444 aa)
       
  0.987
KIR2DL2
Killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 (410 aa)
       
  0.975
LILRB1
Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin rel [...] (652 aa)
       
  0.964
HLA-C
Major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (366 aa)
     
0.961
KLRD1
Killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells (179 aa)
       
  0.961
TAPBP
TAP binding protein (tapasin); Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading) (504 aa)
     
 
  0.956
LILRB2
Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (598 aa)
       
  0.954
CD8A
CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains (235 aa)
     
  0.954
HLA-DQA2
Major histocompatibility complex, class II, DQ alpha 2; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for pres [...] (255 aa)
     
  0.951
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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