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DNAH3 DNAH3 MTMR12 MTMR12 DNAH1 DNAH1 DNAH7 DNAH7 NPHP1 NPHP1 CMTM6 CMTM6 CMTM7 CMTM7 CMTM8 CMTM8 CMTM3 CMTM3 CKLF CKLF PLLP PLLP
"CMTM6" - CKLF-like MARVEL transmembrane domain containing 6 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CMTM6CKLF-like MARVEL transmembrane domain containing 6 (183 aa)    
Predicted Functional Partners:
CMTM8
CKLF-like MARVEL transmembrane domain containing 8 (173 aa)
           
  0.910
CMTM7
CKLF-like MARVEL transmembrane domain containing 7 (175 aa)
           
  0.878
CKLF
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
     
   
  0.842
MTMR12
Myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location (747 aa)
           
  0.529
PLLP
Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity) (182 aa)
           
  0.529
DNAH1
Dynein, axonemal, heavy chain 1; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity) (4265 aa)
           
  0.528
NPHP1
Nephronophthisis 1 (juvenile); Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In conn [...] (733 aa)
           
  0.506
DNAH7
Dynein, axonemal, heavy chain 7; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity) (4024 aa)
           
  0.503
DNAH3
Dynein, axonemal, heavy chain 3; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity) (4116 aa)
           
  0.503
CMTM3
CKLF-like MARVEL transmembrane domain containing 3 (182 aa)
           
  0.451
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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