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RHOQ RHOQ RHOJ RHOJ RAC1 RAC1 FGD6 FGD6 CDC42 CDC42 DOCK10 DOCK10 IL4 IL4 EVI2A EVI2A ARFGEF1 ARFGEF1
"DOCK10" - Dedicator of cytokinesis 10 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
DOCK10Dedicator of cytokinesis 10; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (2186 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (191 aa)
     
  0.929
RAC1
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (211 aa)
     
  0.910
RHOJ
Ras homolog family member J; GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity) (214 aa)
     
 
  0.614
RHOQ
Ras homolog family member Q; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia (205 aa)
     
 
  0.554
FGD6
FYVE, RhoGEF and PH domain containing 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity) (1430 aa)
     
   
  0.455
EVI2A
Ecotropic viral integration site 2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor (259 aa)
     
   
  0.450
IL4
Interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types (PubMed-3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity) (153 aa)
           
  0.423
ARFGEF1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] (1849 aa)
     
   
  0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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