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Welcome to STRING
Protein-Protein Interaction Networks
Functional Enrichment Analysis
Organisms
14094
Proteins
67.6 mio
Interactions
>20 bln
Search
Protein by name
Protein by sequence
Multiple proteins
Multiple sequences
Proteins with Values/Ranks
Organisms
Protein families ("COGs")
... by family name
... by protein name
... by protein sequence
... multiple protein names
... multiple sequences
Examples
Random entry
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Single Protein by Name / Identifier
Protein Name:
(examples:
#1
#2
#3
)
Organism:
auto-detect
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Advanced Settings
Network Type:
full STRING network
physical subnetwork
Required score:
highest confidence (0.900)
high confidence (0.700)
medium confidence (0.400)
low confidence (0.150)
Size cutoff:
no more than 5 interactors
no more than 10 interactors
no more than 20 interactors
no more than 50 interactors
Search
Single Protein by Sequence
Amino Acid Sequence:
(examples:
#1
#2
#3
)
Organism:
auto-detect
Cancel
Select
Advanced Settings
Network Type:
full STRING network
physical subnetwork
Required score:
highest confidence (0.900)
high confidence (0.700)
medium confidence (0.400)
low confidence (0.150)
Size cutoff:
no more than 5 interactors
no more than 10 interactors
no more than 20 interactors
no more than 50 interactors
Search
Multiple Proteins by Names / Identifiers
List Of Names:
(one per line; examples:
#1
#2
#3
)
... or, upload a file:
Browse ...
Organism:
auto-detect
Cancel
Select
Advanced Settings
Network Type:
full STRING network
physical subnetwork
Required score:
highest confidence (0.900)
high confidence (0.700)
medium confidence (0.400)
low confidence (0.150)
FDR stringency:
high (1 percent)
medium (5 percent)
lenient (25 percent)
Search
Multiple Proteins by Sequences
Amino Acid Sequences:
(examples:
#1
#2
)
... or, upload a file:
Browse ...
Organism:
auto-detect
Cancel
Select
Advanced Settings
Network Type:
full STRING network
physical subnetwork
Required score:
highest confidence (0.900)
high confidence (0.700)
medium confidence (0.400)
low confidence (0.150)
FDR stringency:
high (1 percent)
medium (5 percent)
lenient (25 percent)
Search
Proteins with Values/Ranks - Functional Enrichment Analysis
Submit your entire experiment as a list of proteins - no cutoffs.
Behind each protein, put a meaningful value for ranking (fold-change, log-pvalue, abundance, ...).
Proteins with Values:
(one per line; examples:
#1
#2
#3
)
... or, upload a file:
Browse ...
Organism:
Cancel
Select
Advanced Settings
FDR stringency:
high (1 percent)
medium (5 percent)
lenient (25 percent)
Initial sort order:
enrichment score
significance
pathway size
allow anonymized, aggregated use of this data to help us improve
Search
Organisms and Clades
Organism:
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Show Info
Examples and Highlights
Example 1
show
FAA4 and its ten most confident interactors.
FAA4 in yeast is a long chain fatty acyl-CoA synthetase; see it connected to other synthetases as well as regulators.
Example 2
show
The 20 most frequently mutated human cancer genes.
These have a higher-than-expected degree of interconnectivity, and are enriched in characteristic molecular functions.
Example 3
show
A poorly characterized protein from Natronococcus.
It has no annotated domains or functions, but shows some intriguing connections to possible DNA-replication or -repair proteins.
Protein Family by Name
Protein Family Name:
(examples:
#1
#2
#3
)
Search
Protein Family by Protein Name
Protein Name:
(examples:
#1
#2
#3
)
Organism:
auto-detect
Cancel
Select
Search
Protein Family by Protein Sequence
Amino Acid Sequence:
(examples:
#1
#2
#3
)
Organism:
auto-detect
Cancel
Select
Search
Protein Families by Multiple Names
List Of Names:
(examples:
#1
#2
#3
)
... or, upload a file:
Browse ...
Organism:
auto-detect
Cancel
Select
Search
Protein Families by Multiple Sequences
Amino Acid Sequences:
(examples:
#1
#2
)
... or, upload a file:
Browse ...
Organism:
auto-detect
Cancel
Select
Search
