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Welcome to STRING
Protein-Protein Interaction Networks
Functional Enrichment Analysis
Organisms
5090
Proteins
24.6 mio
Interactions
>2000 mio
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Protein by name
Protein by sequence
Multiple proteins
Multiple sequences
Proteins with Values/Ranks
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Organisms
Protein families ("COGs")
... by family name
... by protein name
... by protein sequence
... multiple protein names
... multiple sequences
Examples
Random entry
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Protein Family by Name
Protein Family Name:
(examples:
#1
#2
#3
)
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Protein Families by Multiple Names
List Of Names:
(examples:
#1
#2
#3
)
... or, upload a file:
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Organism:
auto-detect
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Protein Families by Multiple Sequences
Amino Acid Sequences:
(examples:
#1
#2
)
... or, upload a file:
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Organism:
auto-detect
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Protein Family by Protein Name
Protein Name:
(examples:
#1
#2
#3
)
Organism:
auto-detect
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Protein Family by Protein Sequence
Amino Acid Sequence:
(examples:
#1
#2
#3
)
Organism:
auto-detect
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Examples and Highlights
Example 1
show
FAA4 and its ten most confident interactors.
FAA4 in yeast is a long chain fatty acyl-CoA synthetase; see it connected to other synthetases as well as regulators.
Example 2
show
The 20 most frequently mutated human cancer genes.
These have a higher-than-expected degree of interconnectivity, and are enriched in characteristic molecular functions.
Example 3
show
A poorly characterized protein from Methanosaeta.
It has no annotated domains or functions, but shows some intriguing connections to possible DNA-replication or -repair proteins.
Multiple Proteins by Names / Identifiers
List Of Names:
(one per line; examples:
#1
#2
#3
)
... or, upload a file:
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Organism:
auto-detect
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Multiple Proteins by Sequences
Amino Acid Sequences:
(examples:
#1
#2
)
... or, upload a file:
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Organism:
auto-detect
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Organisms and Clades
Organism:
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Show Info
Proteins with Values/Ranks - Functional Enrichment Analysis
Submit your entire experiment as a list of proteins - no cutoffs.
Behind each protein, put a meaningful value for ranking (fold-change, log-pvalue, abundance, ...).
Proteins with Values:
(one per line; examples:
#1
#2
#3
)
... or, upload a file:
Browse ...
Organism:
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Advanced Settings:
FDR stringency:
high (1 percent)
medium (5 percent)
lenient (25 percent)
initial sort order:
enrichment score
significance
pathway size
FDR, ordering ...
allow anonymized, aggregated use of this data to help us improve
Search
Single Protein by Name / Identifier
Protein Name:
(examples:
#1
#2
#3
)
Organism:
auto-detect
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Search
Single Protein by Sequence
Amino Acid Sequence:
(examples:
#1
#2
#3
)
Organism:
auto-detect
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Search