node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1b10 | Dhdh | ENSMUSP00000039114 | ENSMUSP00000011526 | Aldo-keto reductase family 1, member B10 (aldose reductase). | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.936 |
Akr1b3 | Dhdh | ENSMUSP00000100045 | ENSMUSP00000011526 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.929 |
Akr1b3 | Galk1 | ENSMUSP00000100045 | ENSMUSP00000021114 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | 0.449 |
Akr1b7 | Dhdh | ENSMUSP00000007449 | ENSMUSP00000011526 | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity); Belongs to the aldo/keto reductase family. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.945 |
Akr1b8 | Dhdh | ENSMUSP00000040244 | ENSMUSP00000011526 | Aldose reductase-related protein 2. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.943 |
Akr1c21 | Dhdh | ENSMUSP00000021628 | ENSMUSP00000011526 | Aldo-keto reductase family 1 member C21; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids. Belongs to the aldo/keto reductase family. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.539 |
Dhdh | Akr1b10 | ENSMUSP00000011526 | ENSMUSP00000039114 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldo-keto reductase family 1, member B10 (aldose reductase). | 0.936 |
Dhdh | Akr1b3 | ENSMUSP00000011526 | ENSMUSP00000100045 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | 0.929 |
Dhdh | Akr1b7 | ENSMUSP00000011526 | ENSMUSP00000007449 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity); Belongs to the aldo/keto reductase family. | 0.945 |
Dhdh | Akr1b8 | ENSMUSP00000011526 | ENSMUSP00000040244 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldose reductase-related protein 2. | 0.943 |
Dhdh | Akr1c21 | ENSMUSP00000011526 | ENSMUSP00000021628 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldo-keto reductase family 1 member C21; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids. Belongs to the aldo/keto reductase family. | 0.539 |
Dhdh | Ephx1 | ENSMUSP00000011526 | ENSMUSP00000047551 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | 0.919 |
Dhdh | Galk1 | ENSMUSP00000011526 | ENSMUSP00000021114 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | 0.673 |
Dhdh | Galk2 | ENSMUSP00000011526 | ENSMUSP00000092186 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity). | 0.673 |
Dhdh | Kars | ENSMUSP00000011526 | ENSMUSP00000126268 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity; Belongs to the class-I [...] | 0.604 |
Dhdh | Tgds | ENSMUSP00000011526 | ENSMUSP00000022727 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 0.585 |
Ephx1 | Dhdh | ENSMUSP00000047551 | ENSMUSP00000011526 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.919 |
Galk1 | Akr1b3 | ENSMUSP00000021114 | ENSMUSP00000100045 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | 0.449 |
Galk1 | Dhdh | ENSMUSP00000021114 | ENSMUSP00000011526 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.673 |
Galk1 | Tgds | ENSMUSP00000021114 | ENSMUSP00000022727 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 0.592 |