STRINGSTRING
Slc25a39 Slc25a39 Tmem14c Tmem14c Isca1 Isca1 Rundc3a Rundc3a Alas2 Alas2 Iba57 Iba57 Atxn7l3 Atxn7l3 Tmub2 Tmub2 Dcakd Dcakd Ubtf Ubtf Gm16867 Gm16867
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
Slc25a39Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family. (359 aa)    
Predicted Functional Partners:
Tmem14c
Transmembrane protein 14C; Required for normal heme biosynthesis; Belongs to the TMEM14 family.
   
  
 0.711
Isca1
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
   
  
 0.704
Rundc3a
RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family.
   
  
 0.692
Alas2
5-aminolevulinate synthase, erythroid-specific, mitochondrial.
   
  
 0.660
Iba57
Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily.
   
  
 0.654
Atxn7l3
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]
      
 0.647
Tmub2
Transmembrane and ubiquitin-like domain-containing protein 2.
   
  
 0.635
Dcakd
Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family.
   
  
 0.630
Ubtf
Nucleolar transcription factor 1; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
   
  
 0.614
Gm16867
Predicted gene, 16867.
   
  
 0.613
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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