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Txndc15 Txndc15 Tmx1 Tmx1 Fam92a Fam92a Fam98c Fam98c Ttc23 Ttc23 Catsper3 Catsper3 Caml Caml Mob3a Mob3a Slc25a48 Slc25a48 Ints10 Ints10 Ndufaf6 Ndufaf6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Txndc15Thioredoxin domain-containing protein 15; Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis. (344 aa)    
Predicted Functional Partners:
Tmx1
Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
   
  
 0.647
Fam92a
Protein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling. Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (By similarity). Belongs to the FAM92 family.
   
  
 0.611
Fam98c
Family with sequence similarity 98, member C.
   
  
 0.608
Ttc23
Tetratricopeptide repeat protein 23; Participates positively in the ciliary Hedgehog (Hh) signaling.
      
 0.605
Catsper3
Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.
      
 0.569
Caml
Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
   
  
 0.537
Mob3a
MOB kinase activator 3A; May regulate the activity of kinases.
      
 0.535
Slc25a48
Solute carrier family 25 member 48.
      
 0.531
Ints10
Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.
   
  
 0.531
Ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 (By similarity); Belongs to the NDUFAF6 family.
   
  
 0.526
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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