node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Camp | Defb1 | ENSMUSP00000107653 | ENSMUSP00000051754 | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.614 |
Camp | Defb14 | ENSMUSP00000107653 | ENSMUSP00000062781 | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.525 |
Camp | Defb2 | ENSMUSP00000107653 | ENSMUSP00000006745 | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | 0.521 |
Camp | Defb3 | ENSMUSP00000107653 | ENSMUSP00000033852 | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | Beta-defensin 3; Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa; Belongs to the beta-defensin family. LAP/TAP subfamily. | 0.650 |
Ccr6 | Defb1 | ENSMUSP00000095029 | ENSMUSP00000051754 | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.881 |
Ccr6 | Defb14 | ENSMUSP00000095029 | ENSMUSP00000062781 | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.822 |
Ccr6 | Defb2 | ENSMUSP00000095029 | ENSMUSP00000006745 | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | 0.485 |
Ccr6 | Defb3 | ENSMUSP00000095029 | ENSMUSP00000033852 | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | Beta-defensin 3; Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa; Belongs to the beta-defensin family. LAP/TAP subfamily. | 0.479 |
Defb1 | Camp | ENSMUSP00000051754 | ENSMUSP00000107653 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | 0.614 |
Defb1 | Ccr6 | ENSMUSP00000051754 | ENSMUSP00000095029 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | 0.881 |
Defb1 | Defb14 | ENSMUSP00000051754 | ENSMUSP00000062781 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | 0.955 |
Defb1 | Defb2 | ENSMUSP00000051754 | ENSMUSP00000006745 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | 0.448 |
Defb1 | Defb3 | ENSMUSP00000051754 | ENSMUSP00000033852 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 3; Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa; Belongs to the beta-defensin family. LAP/TAP subfamily. | 0.757 |
Defb14 | Camp | ENSMUSP00000062781 | ENSMUSP00000107653 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | 0.525 |
Defb14 | Ccr6 | ENSMUSP00000062781 | ENSMUSP00000095029 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | 0.822 |
Defb14 | Defb1 | ENSMUSP00000062781 | ENSMUSP00000051754 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.955 |
Defb14 | Defb2 | ENSMUSP00000062781 | ENSMUSP00000006745 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | 0.414 |
Defb14 | Defb3 | ENSMUSP00000062781 | ENSMUSP00000033852 | Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 3; Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa; Belongs to the beta-defensin family. LAP/TAP subfamily. | 0.697 |
Defb2 | Camp | ENSMUSP00000006745 | ENSMUSP00000107653 | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. | 0.521 |
Defb2 | Ccr6 | ENSMUSP00000006745 | ENSMUSP00000095029 | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects [...] | 0.485 |