STRINGSTRING
Rbm46 Rbm46 Zfyve28 Zfyve28 Dmrtb1 Dmrtb1 Fau Fau Armc9 Armc9 Catsper4 Catsper4 Ctso Ctso Hspbap1 Hspbap1 Zfp687 Zfp687 Dazl Dazl Ctdsp2 Ctdsp2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rbm46Probable RNA-binding protein 46. (533 aa)    
Predicted Functional Partners:
Zfyve28
Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family.
      
 0.743
Dmrtb1
Doublesex- and mab-3-related transcription factor B1; Belongs to the DMRT family.
      
 0.659
Fau
Ubiquitin-like protein FUBI; Belongs to the ubiquitin family.
   
   0.619
Armc9
LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling. Involved in ciliogenesis (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip.
      
 0.572
Catsper4
Cation channel sperm-associated protein 4; Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
      
 0.564
Ctso
Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
   
  
 0.551
Hspbap1
HSPB1-associated protein 1; May play a role in cellular stress response.
      
 0.543
Zfp687
Zinc finger protein 687; May be involved in transcriptional regulation.
      
 0.529
Dazl
Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.
   
 
 0.521
Ctdsp2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).
    
 
 0.520
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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