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C2cd4c C2cd4c Odf3l2 Odf3l2 Zc3h15 Zc3h15 Fam222a Fam222a Slc35a1 Slc35a1 Theg Theg Cep104 Cep104 Gramd2 Gramd2 Pate14 Pate14 Dlgap3 Dlgap3 Trim23 Trim23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C2cd4cC2 calcium-dependent domain-containing protein 4C; Belongs to the C2CD4 family. (419 aa)    
Predicted Functional Partners:
Odf3l2
Outer dense fiber protein 3-like protein 2; Belongs to the ODF3 family.
      
 0.483
Zc3h15
Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity).
      
 0.472
Fam222a
Protein FAM222A; Belongs to the FAM222 family.
      
 0.455
Slc35a1
CMP-sialic acid transporter; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP- sialic acid and free CMP, but has higher affinity for free CMP ; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
      
 0.442
Theg
Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis.
      
 0.441
Cep104
Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip.
      
 0.431
Gramd2
GRAM domain-containing protein 2A; Participates in the organization ofendoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum- plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
   
 
 0.420
Pate14
Secreted seminal-vesicle Ly-6 protein 1.
   
  
 0.419
Dlgap3
Disks large-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family.
   
  
 0.414
Trim23
E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
      
 0.413
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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