STRINGSTRING
Tchh Tchh Lor Lor Rptn Rptn Padi3 Padi3 Tgm1 Tgm1 Cdsn Cdsn Ppl Ppl Krt33a Krt33a Evpl Evpl Flg Flg Krt25 Krt25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TchhTrichohyalin. (1599 aa)    
Predicted Functional Partners:
Lor
Loricrin; Major keratinocyte cell envelope protein.
   
  
 0.927
Rptn
Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family.
  
 
0.842
Padi3
Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family.
   
  
 0.722
Tgm1
Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).
   
 0.713
Cdsn
Corneodesmosin; Important for the epidermal barrier integrity.
   
 
 0.666
Ppl
Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
   
 0.662
Krt33a
Keratin, type I cuticular Ha3-I.
   
 
 0.657
Evpl
Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
   
 0.657
Flg
Filaggrin.
   
 
0.647
Krt25
Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Plays a role in the cytoskeleton organization (By similarity).
   
 
 0.635
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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