node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd300a | Cd300c | ENSMUSP00000102192 | ENSMUSP00000090123 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | CMRF35-like molecule 6. | 0.501 |
Cd300a | Cd300e | ENSMUSP00000102192 | ENSMUSP00000054883 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.526 |
Cd300a | Cd300lb | ENSMUSP00000102192 | ENSMUSP00000102191 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | CMRF35-like molecule 7; Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP. | 0.658 |
Cd300a | Cd300lg | ENSMUSP00000102192 | ENSMUSP00000102782 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. Belongs to the CD300 family. | 0.489 |
Cd300a | Fcer1g | ENSMUSP00000102192 | ENSMUSP00000078875 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] | 0.520 |
Cd300a | Hcst | ENSMUSP00000102192 | ENSMUSP00000074573 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.405 |
Cd300a | Trem1 | ENSMUSP00000102192 | ENSMUSP00000038636 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | 0.658 |
Cd300a | Trem2 | ENSMUSP00000102192 | ENSMUSP00000108863 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as [...] | 0.568 |
Cd300a | Treml1 | ENSMUSP00000102192 | ENSMUSP00000153300 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.440 |
Cd300a | Treml4 | ENSMUSP00000102192 | ENSMUSP00000118772 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | Trem-like transcript 4 protein; Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand- induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but [...] | 0.435 |
Cd300c | Cd300a | ENSMUSP00000090123 | ENSMUSP00000102192 | CMRF35-like molecule 6. | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). | 0.501 |
Cd300c | Cd300e | ENSMUSP00000090123 | ENSMUSP00000054883 | CMRF35-like molecule 6. | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.513 |
Cd300c | Cd300lb | ENSMUSP00000090123 | ENSMUSP00000102191 | CMRF35-like molecule 6. | CMRF35-like molecule 7; Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP. | 0.647 |
Cd300c | Cd300lg | ENSMUSP00000090123 | ENSMUSP00000102782 | CMRF35-like molecule 6. | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. Belongs to the CD300 family. | 0.475 |
Cd300c | Fcer1g | ENSMUSP00000090123 | ENSMUSP00000078875 | CMRF35-like molecule 6. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] | 0.621 |
Cd300c | Hcst | ENSMUSP00000090123 | ENSMUSP00000074573 | CMRF35-like molecule 6. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.587 |
Cd300c | Trem1 | ENSMUSP00000090123 | ENSMUSP00000038636 | CMRF35-like molecule 6. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | 0.544 |
Cd300c | Trem2 | ENSMUSP00000090123 | ENSMUSP00000108863 | CMRF35-like molecule 6. | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as [...] | 0.457 |
Cd300c | Treml1 | ENSMUSP00000090123 | ENSMUSP00000153300 | CMRF35-like molecule 6. | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.439 |
Cd300c | Treml4 | ENSMUSP00000090123 | ENSMUSP00000118772 | CMRF35-like molecule 6. | Trem-like transcript 4 protein; Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand- induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but [...] | 0.429 |