STRINGSTRING
Capn9 Capn9 Cast Cast Capns1 Capns1 Capns2 Capns2 Gm1110 Gm1110 Tanc2 Tanc2 Gkn1 Gkn1 Cacng1 Cacng1 Cwh43 Cwh43 2310022B05Rik 2310022B05Rik Pdlim3 Pdlim3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Capn9Calpain-9; Calcium-regulated non-lysosomal thiol-protease. (690 aa)    
Predicted Functional Partners:
Cast
Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family.
   
 
 0.796
Capns1
Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
   
0.716
Capns2
Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity).
   
0.709
Gm1110
Beta-galactosidase.
   
  
 0.596
Tanc2
Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the TANC family.
    
 
 0.572
Gkn1
Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
   
  
 0.540
Cacng1
Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
  
 0.531
Cwh43
PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. Belongs to the PGAP2IP family.
      
 0.530
2310022B05Rik
Uncharacterized protein C1orf198 homolog.
      
 0.523
Pdlim3
PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells.
   
  
 0.507
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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