STRINGSTRING
Itpripl1 Itpripl1 Tmem102 Tmem102 Wdr54 Wdr54 Fam178b Fam178b Faap100 Faap100 Mfsd10 Mfsd10 Man2b2 Man2b2 Tmx4 Tmx4 Susd1 Susd1 Nol6 Nol6 Mex3a Mex3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
Itpripl1Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1. (547 aa)    
Predicted Functional Partners:
Tmem102
Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.
   
  
 0.647
Wdr54
WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.
      
 0.629
Fam178b
Protein FAM178B.
      
 0.521
Faap100
Fanconi anemia core complex-associated protein 100; Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity).
   
 
 0.488
Mfsd10
Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non- steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity); Belongs to the major facilitator superfamily.
   
  
 0.485
Man2b2
Epididymis-specific alpha-mannosidase; Plays an important role in the early step of spermatogenesis; Belongs to the glycosyl hydrolase 38 family.
      
 0.460
Tmx4
Thioredoxin-related transmembrane protein 4.
      
 0.460
Susd1
Sushi domain-containing 1.
   
 
 0.450
Nol6
Nucleolar protein 6; Belongs to the NRAP family.
   
 
 0.425
Mex3a
Mex3 RNA-binding family member A.
      
 0.418
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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