node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ash2l | Cxxc1 | ENSRNOP00000068617 | ENSRNOP00000020472 | ASH2-like histone lysine methyltransferase complex subunit. | CXXC finger 1 (PHD domain), isoform CRA_b. | 0.995 |
Ash2l | Dpy30 | ENSRNOP00000068617 | ENSRNOP00000070382 | ASH2-like histone lysine methyltransferase complex subunit. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.999 |
Ash2l | Hcfc1 | ENSRNOP00000068617 | ENSRNOP00000073793 | ASH2-like histone lysine methyltransferase complex subunit. | Host cell factor C1. | 0.975 |
Ash2l | Kansl1 | ENSRNOP00000068617 | ENSRNOP00000074797 | ASH2-like histone lysine methyltransferase complex subunit. | KAT8 regulatory NSL complex subunit 1. | 0.755 |
Ash2l | Kmt2a | ENSRNOP00000068617 | ENSRNOP00000020573 | ASH2-like histone lysine methyltransferase complex subunit. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.999 |
Ash2l | Kmt2d | ENSRNOP00000068617 | ENSRNOP00000069442 | ASH2-like histone lysine methyltransferase complex subunit. | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.997 |
Ash2l | Rbbp5 | ENSRNOP00000068617 | ENSRNOP00000031945 | ASH2-like histone lysine methyltransferase complex subunit. | RB-binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |
Ash2l | Setd1b | ENSRNOP00000068617 | ENSRNOP00000001807 | ASH2-like histone lysine methyltransferase complex subunit. | SET domain containing 1B. | 0.986 |
Ash2l | Wdr5 | ENSRNOP00000068617 | ENSRNOP00000011556 | ASH2-like histone lysine methyltransferase complex subunit. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.999 |
Cxxc1 | Ash2l | ENSRNOP00000020472 | ENSRNOP00000068617 | CXXC finger 1 (PHD domain), isoform CRA_b. | ASH2-like histone lysine methyltransferase complex subunit. | 0.995 |
Cxxc1 | Dpy30 | ENSRNOP00000020472 | ENSRNOP00000070382 | CXXC finger 1 (PHD domain), isoform CRA_b. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.987 |
Cxxc1 | Hcfc1 | ENSRNOP00000020472 | ENSRNOP00000073793 | CXXC finger 1 (PHD domain), isoform CRA_b. | Host cell factor C1. | 0.865 |
Cxxc1 | Kmt2d | ENSRNOP00000020472 | ENSRNOP00000069442 | CXXC finger 1 (PHD domain), isoform CRA_b. | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.465 |
Cxxc1 | Rbbp5 | ENSRNOP00000020472 | ENSRNOP00000031945 | CXXC finger 1 (PHD domain), isoform CRA_b. | RB-binding protein 5, histone lysine methyltransferase complex subunit. | 0.997 |
Cxxc1 | Setd1b | ENSRNOP00000020472 | ENSRNOP00000001807 | CXXC finger 1 (PHD domain), isoform CRA_b. | SET domain containing 1B. | 0.977 |
Cxxc1 | Wdr5 | ENSRNOP00000020472 | ENSRNOP00000011556 | CXXC finger 1 (PHD domain), isoform CRA_b. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.978 |
Dpy30 | Ash2l | ENSRNOP00000070382 | ENSRNOP00000068617 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | ASH2-like histone lysine methyltransferase complex subunit. | 0.999 |
Dpy30 | Cxxc1 | ENSRNOP00000070382 | ENSRNOP00000020472 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | CXXC finger 1 (PHD domain), isoform CRA_b. | 0.987 |
Dpy30 | Hcfc1 | ENSRNOP00000070382 | ENSRNOP00000073793 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Host cell factor C1. | 0.947 |
Dpy30 | Kansl1 | ENSRNOP00000070382 | ENSRNOP00000074797 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | KAT8 regulatory NSL complex subunit 1. | 0.726 |