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Ephx2 Ephx2 Cyp2j4 Cyp2j4 Cyp2c11 Cyp2c11 Pnp Pnp Mtap Mtap Cyp2c23 Cyp2c23 Prkag3 Prkag3 Prkag2 Prkag2 Nudt12 Nudt12 Cyp2c7 Cyp2c7 Nudt13 Nudt13
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Ephx2Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C- terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators (By similarity). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy- hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy- hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (554 aa)    
Predicted Functional Partners:
Cyp2j4
Cytochrome P450, family 2, subfamily j, polypeptide 4; Belongs to the cytochrome P450 family.
  
 0.982
Cyp2c11
Cytochrome P450 2C11; Metabolizes testosterone mainly in positions 2 alpha and 16 alpha; Belongs to the cytochrome P450 family.
  
 0.977
Pnp
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.973
Mtap
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  
 
 0.973
Cyp2c23
Cytochrome P450 2C23; Predominant enzyme isoform responsible for arachidonic acid epoxidation in the rat kidney. Catalyzes the NADPH-dependent metabolism of arachidonic acid to a mixture of 5,6-, 8,9-, 11,12-, and 14,15- epoxyeicosatrienoic acids (EETS) as the only oxygenation products. Low rate of lauric acid hydroxylation at the (omega-1)-position; Belongs to the cytochrome P450 family.
  
 0.972
Prkag3
Protein kinase, AMP-activated, gamma 3 non-catatlytic subunit (Predicted).
  
 
 0.965
Prkag2
Protein kinase AMP-activated non-catalytic subunit gamma 2.
  
 
 0.965
Nudt12
Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted).
  
 0.964
Cyp2c7
Cytochrome P450 2C7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  
 0.958
Nudt13
Nudix hydrolase 13.
  
 
 0.957
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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