STRINGSTRING
NQO1 NQO1 GGCX GGCX VKORC1 VKORC1 Vkorc1l1 Vkorc1l1 KEAP1 KEAP1 TMCO3 TMCO3 NFE2L2 NFE2L2 ODC1 ODC1 TP53 TP53 RIDA RIDA HMOX1 HMOX1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NQO1NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis; Belongs to the NAD(P)H dehydrogenase (quinone) family. (275 aa)    
Predicted Functional Partners:
GGCX
Gamma-glutamyl carboxylase.
     
 0.941
VKORC1
Vitamin K epoxide reductase complex subunit 1.
     
 0.939
Vkorc1l1
VKc domain-containing protein.
     
 0.817
KEAP1
Kelch like ECH associated protein 1.
      
 0.781
TMCO3
Transmembrane and coiled-coil domains 3.
  
 
 0.771
NFE2L2
Nuclear factor, erythroid 2 like 2.
   
 0.770
ODC1
Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 0.767
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 
 0.743
RIDA
Reactive intermediate imine deaminase A homolog.
    
 0.741
HMOX1
Heme oxygenase 1.
      
 0.738
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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