STRINGSTRING
DSY3155 DSY3155 DSY4482 DSY4482 DSY1509 DSY1509 DSY3646 DSY3646 DSY4972 DSY4972 mtgB mtgB DSY2719 DSY2719 DSY1268 DSY1268 DSY1647 DSY1647 DSY0589 DSY0589 mtgA mtgA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DSY3155Hypothetical protein; Probably harbors a corrinoid prosthetic group and acts as a methyl group carrier between MtgB and MtgA. A methyl group from glycine betaine is likely first transferred to the corrinoid prosthetic group of the enzyme by MtgB, and then transferred to tetrahydrofolate (THF) by MtgA. The methyl group may then be ultimately converted to carbon dioxide, and its oxidation would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine. (216 aa)    
Predicted Functional Partners:
DSY4482
Hypothetical protein; Similarity to COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain(Evalue: 8E-56).
  
 0.977
DSY1509
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 2E-37).
  
 0.974
DSY3646
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 2E-40).
  
 0.973
DSY4972
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 3E-39).
  
 0.973
mtgB
Hypothetical protein; Methyltransferase able to methylate free cob(I)alamin in vitro, using glycine betaine as the methyl donor, yealding methylcobalamin (methylCbl) and dimethylglycine. In vivo, probably carries out the methylation of a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate (THF) for ultimate conversion to carbon dioxide; oxidation of the methyl group would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth o [...]
  
 0.971
DSY2719
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 1E-31).
  
 0.958
DSY1268
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 4E-30).
  
 0.957
DSY1647
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 1E-28).
  
 0.955
DSY0589
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 1E-30).
  
 0.954
mtgA
Hypothetical protein; Methyltransferase able to catalyze the transfer of a methyl group from methylcobalamin (methylCbl) to tetrahydrofolate (THF) in vitro, to generate methyl-THF and cob(I)alamin. In vivo, the methyl group probably comes from the adjacently encoded methylated corrinoid protein DSY3155. The methyl group may then be ultimately converted to carbon dioxide, and its oxidation would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine.
    
 0.954
Your Current Organism:
Desulfitobacterium hafniense
NCBI taxonomy Id: 138119
Other names: D. hafniense Y51, Desulfitobacterium hafniense Y51, Desulfitobacterium hafniense str. Y51, Desulfitobacterium hafniense strain Y51, Desulfitobacterium sp. Y51
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