STRINGSTRING
hisG hisG hisI hisI hisD hisD hisZ hisZ hisF hisF hisA hisA hisB hisB hisH hisH hisC hisC hisS hisS prs prs
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisGHypothetical protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (223 aa)    
Predicted Functional Partners:
hisI
Hypothetical protein; Similarity to COG0139 Phosphoribosyl-AMP cyclohydrolase(Evalue: 5E-29); In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisD
Hypothetical protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
hisZ
Hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 0.999
hisF
Hypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.997
hisA
Hypothetical protein; Similarity to COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase(Evalue: 2E-61).
 
  
 0.997
hisB
Hypothetical protein; Similarity to COG0131 Imidazoleglycerol-phosphate dehydratase(Evalue: 6E-51).
 
  
 0.997
hisH
Hypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.996
hisC
Hypothetical protein; Similarity to COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase(Evalue: 3E-52); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.982
hisS
Hypothetical protein; Similarity to COG0124 Histidyl-tRNA synthetase(Evalue: 1E-120).
 
 0.928
prs
Hypothetical protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.862
Your Current Organism:
Desulfitobacterium hafniense
NCBI taxonomy Id: 138119
Other names: D. hafniense Y51, Desulfitobacterium hafniense Y51, Desulfitobacterium hafniense str. Y51, Desulfitobacterium hafniense strain Y51, Desulfitobacterium sp. Y51
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