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hisG hisG hisI hisI hisD hisD hisB hisB hisA hisA hisZ hisZ hisF hisF ABM70700.1 ABM70700.1 prsA prsA ABM70701.1 ABM70701.1 hisH hisH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisGPossible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa)    
Predicted Functional Partners:
hisI
COG139 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.988
hisB
COG131 Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism].
 
  
 0.979
hisA
COG106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism].
 
  
 0.979
hisZ
COG124 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].
 
 0.979
hisF
Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.900
ABM70700.1
Hypothetical protein; COG107 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Belongs to the HisA/HisF family.
 
  
 0.877
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.861
ABM70701.1
Hypothetical protein; COG118 Glutamine amidotransferase [Amino acid transport and metabolism].
 
  
 0.843
hisH
Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.831
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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